Normalization of blood loss in women with heavy menstrual bleeding treated with an oral contraceptive containing estradiol valerate/dienogest

Contraception

Volumn 86, Issue 2, 2012, Pages 96-101

  Fraser, Ian S ^a   Jensen, Jeffrey ^b   Schaefers, Matthias ^c   Mellinger, Uwe ^c   Parke, Susanne ^c   Serrani, Marco ^c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c BAYER PHARMA AG   (Germany)

Author keywords

Estradiol valerate dienogest; Heavy menstrual bleeding; Menstrual blood loss; Oral contraceptive

Indexed keywords

DIENOGEST PLUS ESTRADIOL VALERATE; PLACEBO;

ADULT; ARTICLE; AUSTRALIA; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; EUROPE; FEMALE; HEAVY MENSTRUAL BLEEDING; HUMAN; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; MENSTRUATION; MENSTRUATION DISORDER; MULTIPLE CYCLE TREATMENT; NORTH AMERICA; ORAL CONTRACEPTION; RANDOMIZED CONTROLLED TRIAL; THERAPY EFFECT; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANDROGENS; CONTRACEPTIVES, ORAL, COMBINED; CONTRACEPTIVES, ORAL, HORMONAL; DOUBLE-BLIND METHOD; ESTRADIOL; ESTROGENS; FEMALE; HUMANS; INTENTION TO TREAT ANALYSIS; MENORRHAGIA; MIDDLE AGED; NANDROLONE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84859717670     PISSN: 00107824     EISSN: 18790518     Source Type: Journal    
DOI: 10.1016/j.contraception.2011.11.011     Document Type: Article

References (13)

1. H.J. Ahrendt, D. Makalova, S. Parke, U. Mellinger, and D. Mansour Bleeding pattern and cycle control with an estradiol-based oral contraceptive: a seven-cycle, randomized comparative trial of estradiol valerate/dienogest and ethinyl estradiol/levonorgestrel Contraception 80 2009 436 444
2. S. Palacios, L. Wildt, S. Parke, A. Machlitt, T. Romer, and J. Bitzer Efficacy and safety of a novel oral contraceptive based on oestradiol (oestradiol valerate/dienogest): a phase III trial Eur J Obstet Gynecol Reprod Biol 149 2010 57 62
3. L. Hallberg, A.M. Hogdahl, L. Nilsson, and G. Rybo Menstrual blood loss - a population study. Variation at different ages and attempts to define normality Acta Obstet Gynecol Scand 45 1966 320 351
4. I.S. Fraser, T. Römer, and S. Parke Effective treatment of heavy and/or prolonged menstrual bleeding with an oral contraceptive containing oestradiol valerate and dienogest: a randomised, double-blind phase III trial Hum Reprod 26 2011 2698 2708
5. J.T. Jensen, S. Parke, U. Mellinger, A. Machlitt, and I.S. Fraser Effective treatment of heavy menstrual bleeding with estradiol valerate and dienogest: a randomized controlled trial Obstet Gynecol 117 2011 777 787
6. I.S. Fraser, S. Parke, U. Mellinger, A. Machlitt, M. Serrani, and J. Jensen Effective treatment of heavy and/or prolonged menstrual bleeding without organic cause: pooled analysis of two multinational, randomized, double-blind, placebo-controlled trials of oestradiol valerate and dienogest Eur J Contracept Reprod Health Care 16 2011 258 269
7. A.M. Kaunitz, F. Bissonnette, I. Monteiro, E. Lukkari-Lax, C. Muysers, and J.T. Jensen Levonorgestrel-releasing intrauterine system or medroxyprogesterone for heavy menstrual bleeding: a randomized controlled trial Obstet Gynecol 116 2010 625 632
8. A.S. Lukes, K.A. Moore, and K.N. Muse Tranexamic acid treatment for heavy menstrual bleeding: a randomized controlled trial Obstet Gynecol 116 2010 865 875
9. L. Hallberg, and L. Nilsson Determination of menstrual blood loss Scand J Clin Lab Invest 16 1964 244 248
10. P.C. Reid, and S. Virtanen-Kari Randomised comparative trial of the levonorgestrel intrauterine system and mefenamic acid for the treatment of idiopathic menorrhagia: a multiple analysis using total menstrual fluid loss, menstrual blood loss and pictorial blood loss assessment charts BJOG 112 2005 1121 1125 (Pubitemid 41632669)
11. M.M. Shabaan, M.S. Zakherah, S.A. El-Nashar, and G.H. Sayed Levonorgestrel-releasing intrauterine system compared to low-dose combined oral contraceptive pills for idiopathic menorrhagia: a randomized clinical trial Contraception 83 2011 48 54
12. L. Nilsson, and G. Rybo Treatment of menorrhagia Am J Obstet Gynecol 110 1971 713 720
13. A.S. Lukes, K. Muse, H.E. Richter, K.A. Moore, and D.L. Patrick Estimating a meaningful reduction in menstrual blood loss for women with heavy menstrual bleeding Curr Med Res Opin 26 2010 2673 2678