Effect of smoking on oxygen delivery and outcome in patients treated with radiotherapy for head and neck squamous cell carcinoma - A prospective study

Radiotherapy and Oncology

Volumn 103, Issue 1, 2012, Pages 38-44

  Hoff, Camilla Molich ^a   Grau, Cai ^a   Overgaard, Jens ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Carboxyhemoglobin; Head and neck squamous cell cancer; Hemoglobin; Hypoxia; Prospective study; Radiotherapy; Smoking

Indexed keywords

CARBOXYHEMOGLOBIN; HEMOGLOBIN; OXYGEN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CANCER CONTROL; CANCER PATIENT; DISEASE SPECIFIC SURVIVAL; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; LARYNX CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; OVERALL SURVIVAL; OXYGEN TRANSPORT; PHARYNX CARCINOMA; PRIORITY JOURNAL; PROSPECTIVE STUDY; SECOND CANCER; SMOKING; SMOKING CESSATION; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME; VENOUS BLOOD;

ADULT; AGED; AGED, 80 AND OVER; CARBOXYHEMOGLOBIN; CARCINOMA, SQUAMOUS CELL; FEMALE; HEAD AND NECK NEOPLASMS; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; OXYGEN; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SMOKING;

EID: 84859717212     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.01.011     Document Type: Article

References (40)

1. Hoff CM, Hansen HS, Overgaard M, Grau C, Johansen J, Bentzen J, et al. The importance of haemoglobin level and effect of transfusion in HNSCC patients treated with radiotherapy-results from the randomized DAHANCA 5 study. Radiother Oncol 2011;98:28-33.
2. Overgaard J. Sensitization of hypoxic tumour cells-clinical experience. Int J Radiat Biol 1989;56:801-11. (Pubitemid 20002032)
3. Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005;77:18-24. (Pubitemid 41503384)
4. Overgaard J. Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck - A systematic review and meta-analysis. Radiother Oncol 2011;100:22-32.
5. Hirst DG. What is the importance of anaemia in radiotherapy? The value of animal studies. Radiother Oncol 1991;20:29-33.
6. Hirst DG. Anemia: a problem or an opportunity in radiotherapy? Int J Radiat Oncol Biol Phys 1986;12:2009-17. (Pubitemid 17188993)
7. Lawther PJ, Commins BT. Cigarette smoking and exposure to carbon monoxide. Ann NY Acad Sci 1970;174:135-47.
8. Siemann DW, Hill RP, Bush RS. Smoking: the influence of carboxyhemoglobin (HbCO) on tumor oxygenation and response to radiation. Int J Radiat Oncol Biol Phys 1978;4:657-62. (Pubitemid 9019858)
9. Grau C, Nordsmark M, Khalil AA, Horsman MR, Overgaard J. Effect of carbon monoxide breathing on hypoxia and radiation response in the SCCVII tumor in vivo. Int J Radiat Oncol Biol Phys 1994;29:449-54. (Pubitemid 24187908)
10. Grau C, Khalil AA, Nordsmark M, Horsman MR, Overgaard J. The relationship between carbon monoxide breathing, tumour oxygenation and local tumour control in the C3H mammary carcinoma in vivo. Br J Cancer 1994;69:50-7. (Pubitemid 24021822)
11. Grau C, Horsman MR, Overgaard J. Influence of carboxyhemoglobin level on tumor growth, blood flow, and radiation response in an experimental model. Int J Radiat Oncol Biol Phys 1992;22:421-4.
12. Siemann DW, Macler LM. Tumor radiosensitization through reductions in hemoglobin affinity. Int J Radiat Oncol Biol Phys 1986;12:1295-7. (Pubitemid 16030602)
13. Overgaard J, Nielsen JE, Grau C. Effect of carboxyhemoglobin on tumor oxygen unloading capacity in patients with squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 1992;22:407-10.
14. Overgaard J. The influence of haemoglobin concentration on the response to radiotherapi. Scand J Clin Lab Invest 1988;48:49-53.
15. Hoff CM, Lassen P, Eriksen JG, Hansen HS, Specht L, Overgaard M, et al. Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - Results from the randomized DAHANCA 5 and 7 trials. Acta Oncol 2011;50:1006-14.
16. Lassen P. The role of Human papillomavirus in head and neck cancer and the impact on radiotherapy outcome. Radiother Oncol 2010;95:371-80.
17. Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 2009;27:1992-8.
18. Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J. HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer. Radiother Oncol 2010;94:30-5.
19. Overgaard J, Hansen HS, Overgaard M, Bastholt L, Berthelsen A, Specht L, et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 1998;46:135-46. (Pubitemid 28109172)
20. Chen AM, Chen LM, Vaughan A, Farwell DG, Luu Q, Purdy JA, et al. Head and neck cancer among lifelong never-smokers and ever-smokers: matched-pair analysis of outcomes after radiation therapy. Am J Clin Oncol 2011; 34:270-5.
21. Chen AM, Chen LM, Vaughan A, Sreeraman R, Farwell DG, Luu Q, et al. Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcome. Int J Radiat Oncol Biol Phys 2011;79:414-9.
22. Browman GP, Wong G, Hodson I, Sathya J, Russell R, McAlpine L, et al. Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer. N Engl J Med 1993;328:159-63. (Pubitemid 23021501)
23. Nguyen SK, Masson-Cote L, Fortin A, Dagnault A. Influence of smoking status on treatment outcomes after post-operative radiation therapy for non-small-cell lung cancer. Radiother Oncol 2010;96:89-93.
24. Mortensen LS, Busk M, Nordsmark M, Jakobsen S, Theil J, Overgaard J, et al. Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: a preclinical study. Radiother Oncol 2011;99:418-23.
25. Hendrickson K, Phillips M, Smith W, Peterson L, Krohn K, Rajendran J. Hypoxia imaging with [F-18] FMISO-PET in head and neck cancer: Potential for guiding intensity modulated radiation therapy in overcoming hypoxia-induced treatment resistance. Radiother Oncol 2011;101:369-75.
26. Maftei CA, Shi K, Bayer C, Astner ST, Vaupel P. Comparison of (immuno-) fluorescence data with serial [(1)F]Fmiso PET/CT imaging for assessment of chronic and acute hypoxia in head and neck cancers. Radiother Oncol 2011;99:412-7.
27. Choi W, Lee SW, Park SH, Ryu JS, Oh SJ, Im KC, et al. Planning study for available dose of hypoxic tumor volume using fluorine-18-labeled fluoromisonidazole positron emission tomography for treatment of the head and neck cancer. Radiother Oncol 2010;97:176-82.
28. Maftei CA, Bayer C, Shi K, Astner ST, Vaupel P. Changes in the fraction of total hypoxia and hypoxia subtypes in human squamous cell carcinomas upon fractionated irradiation: Evaluation using pattern recognition in microcirculatory supply units. Radiother Oncol 2011;101:209-16.
29. Hald J, Overgaard J, Grau C. Evaluation of objective measures of smoking status-a prospective clinical study in a group of head and neck cancer patients treated with radiotherapy. Acta Oncol 2003;42:154-9. (Pubitemid 36570780)
30. Warren GW, Arnold SM, Valentino JP, Gal TJ, Hyland AJ, Singh AK, et al. Accuracy of self-reported tobacco assessments in a head and neck cancer treatment population. Radiother Oncol 2012;103:45-8.
31. Wilson D, Parsons J, Wakefield M. The health-related quality-of-life of never smokers, ex-smokers, and light, moderate, and heavy smokers. Prev Med 1999;29:139-44. (Pubitemid 29434520)
32. Jensen K, Jensen AB, Grau C. Smoking has a negative impact upon health related quality of life after treatment for head and neck cancer. Oral Oncol 2007;43:187-92. (Pubitemid 46176707)
33. Alsadius D, Hedelin M, Johansson KA, Pettersson N, Wilderang U, Lundstedt D, et al. Tobacco smoking and long-lasting symptoms from the bowel and the anal-sphincter region after radiotherapy for prostate cancer. Radiother Oncol 2011:495-501.
34. Zevallos JP, Mallen MJ, Lam CY, Karam-Hage M, Blalock J, Wetter DW, et al. Complications of radiotherapy in laryngopharyngeal cancer: effects of a prospective smoking cessation program. Cancer 2009;115:4636-44.
35. Trinkaus M, Corry J, Rischin D. Comparison of self-reported smoking status and physician-recorded smoking status among patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). Radiother Oncol 2011;98:143-4.
36. Decker J, Goldstein JC. Risk factors in head and neck cancer. N Engl J Med 1982;306:1151-5. (Pubitemid 12161338)
37. Stewart RD, Baretta ED, Platte LR, Stewart EB, Kalbfleisch JH, Van YB, et al. Carboxyhemoglobin levels in American blood donors. JAMA 1974;229: 1187-95.
38. Eisen ME, Hammond EC. The effect of smoking on packed cell volume, red blood cell counts, haemoglobin and platelet counts. Can Med Assoc J 1956;75: 520-3.
39. Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363:24-35.
40. Garces YI, Schroeder DR, Nirelli LM, Croghan GA, Croghan IT, Foote RL, et al. Second primary tumors following tobacco dependence treatments among head and neck cancer patients. Am J Clin Oncol 2007;30:531-9. (Pubitemid 47537956)