Physiologically based pharmacokinetic modeling in pediatric drug development: A Clinician's request for a more integrated approach

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Allegaert, Karel ^a   Smits, Anne ^a   Van Den Anker, Johannes N ^b,c,d  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE; CEFAZOLIN; IBUPROFEN; INDOMETACIN; VANCOMYCIN;

ARTICLE; CLINICAL OBSERVATION; CONCENTRATION (PARAMETERS); DRUG DEVELOPMENT; HEALTH CARE PERSONNEL; HUMAN; IN VIVO STUDY; PHARMACOLOGICAL SCIENCE; PHYSIOLOGY; BIOLOGICAL MODEL; DRUG DESIGN; NOTE; PHARMACOKINETICS;

DRUG DESIGN; HUMANS; MODELS, BIOLOGICAL; PHARMACOKINETICS;

EID: 84859709873     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/103763     Document Type: Article

References (8)

1. Khalil F., Ler S., Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development Journal of Biomedicine and Biotechnology 2011 2011 13
2. De Cock R. F., Piana C., Krekels E. H., Danhof M., Allegaert K., Knibbe C. A. J., The role of population PK-PD modelling in paediatric clinical research European Journal of Clinical Pharmacology 2011 67 supplement 1 S5 S16
3. Ler S., Barrett J. S., Meibohm B., The in silico child: using simulation to guide pediatric drug development and manage pediatric pharmacotherapy Journal of Clinical Pharmacology 2009 49 8 889 904
4. Bartelink I. H., Rademaker C. M., Schobben A. F., van den Anker J. N., Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations Clinical Pharmacokinetics 2006 45 11 1077 1097 (Pubitemid 44631388)
5. Johnson T. N., Rostami-Hodjegan A., Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice Paediatric Anaesthesia 2011 21 3 291 301
6. Allegaert K., Verbesselt R., Naulaers G., Van Den Anker J. N., Rayyan M., Debeer A., De Hoon J., Developmental pharmacology: neonates are not just small adults Acta Clinica Belgica 2008 63 1 16 24 (Pubitemid 351311069)
7. Allegaert K., Anderson B. J., van den Anker J. N., Vanhaesebrouck S., de Zegher F., Renal drug clearance in preterm neonates: relation to prenatal growth Therapeutic Drug Monitoring 2007 29 3 284 291 (Pubitemid 47262257)
8. Claassen K., Willmann S., Thelen K., Coboeken K., Allegaert K., Lippert. J., Physiology-based simulations of amikacin pharmacokinetics in preterm neonates. PAGE, 19th meeting Berlin, abstract 1859, 2010, http://www.page- meeting.org/?abstract=1859