Histamine regulation of biliary proliferation

Journal of Hepatology

Volumn 56, Issue 5, 2012, Pages 1204-1206

  Francis, Heather ^a,b   Meng, Fanyin ^a,b   Gaudio, Eugenio ^a,b   Alpini, Gianfranco ^a,b  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Biogenic amines; cAMP; Cholangiocarcinoma; Cholangiocytes; Cholestasis; Proliferation; Receptor

Indexed keywords

CALCIUM ION; CLOBENPROPIT; CYCLIC AMP; CYTOKERATIN 19; CYTOKERATIN 7; CYTOKERATIN 8; G PROTEIN COUPLED RECEPTOR; GAMMA GLUTAMYLTRANSFERASE; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; HISTIDINE; HISTIDINE DECARBOXYLASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE C ALPHA; TRANSCRIPTION FACTOR ELK 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; BILE DUCT DISEASE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; CHOLANGIOCYTE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; HEPATOBILIARY SYSTEM; LIVER ISCHEMIA; LIVER REGENERATION; LIVER RESECTION; NONHUMAN; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84859709021     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.09.023     Document Type: Note

References (10)

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2. Alpini G, Glaser S, Robertson W, Rodgers RE, Phinizy JL, Lasater J, et al. Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion. Am J Physiol Gastrointest Liver Physiol 1997;272:G1064-G1074.
3. Mancinelli R, Franchitto A, Gaudio E, Onori P, Glaser S, Francis H, et al. After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes. Am J Pathol 2010;176:1790-1800.
4. Francis H, Franchitto A, Ueno Y, Glaser S, DeMorrow S, Venter J, et al. H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway. Lab Invest 2007;87:473-487. (Pubitemid 46633123)
5. Francis H, Glaser S, DeMorrow S, Gaudio E, Ueno Y, Venter J, et al. Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CAMK I/CREB pathway. Am J Physiol Cell Physiol 2008;295:C499-C513. (Pubitemid 352755782)
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9. Francis H, Onori P, Gaudio E, Franchitto A, DeMorrow S, Venter J, et al. H3 histamine receptor-mediated activation of protein kinase C alpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. Mol Cancer Res 2009;7:1704-1713.
10. Meng F, Han Y, Staloch D, Francis T, Stokes A, Francis H. The H4HR agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of EMT and tumor metastasis. Hepatology 2011, July 25 [Epub ahead of print]. doi:10.1002/hep.24573.