Location of Xpert® MTB/RIF in centralised laboratories in South Africa undermines potential impact

International Journal of Tuberculosis and Lung Disease

Volumn 16, Issue 5, 2012, Pages 701-

  Lawn, Stephen D ^a,b   Kerkhoff, Andrew D ^a,c   Wood, Robin ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSTIC VALUE; EARLY INTERVENTION; HEALTH CARE FACILITY; HUMAN; LETTER; LUNG TUBERCULOSIS; MEDICAL TECHNOLOGY; MOLECULAR DIAGNOSIS; MORTALITY; POINT OF CARE TESTING; PRIORITY JOURNAL; SOUTH AFRICA; SPUTUM CYTODIAGNOSIS; SPUTUM SMEAR;

ANTITUBERCULAR AGENTS; HUMANS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; RIFAMPIN; TUBERCULOSIS;

EID: 84859701203     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: 10.5588/ijtld.12.0131     Document Type: Letter

References (6)

1. Trébucq A, Enarson D A, Chiang C Y, et al. Xpert® MTB/RIF for national tuberculosis programmes in low-income countries: when, where and how? Int J Tuberc Lung Dis 2011; 15: 1567-1571.
2. Lawn S D, Nicol M P. Xpert® MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance. Future Microbiol 2011; 6: 1067-1082.
3. Boehme C C, Nicol M P, Nabeta P, et al. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet 2011; 377: 1495-1505.
4. Lawn S D, Brooks S V, Kranzer K, et al. Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study. PLoS Med 2011; 8: e1001067.
5. Lawn S D, Kerkhoff A D, Vogt M. Characteristics and early outcomes of patients with Xpert MTB/RIF-negative pulmonary tuberculosis diagnosed during screening before antiretroviral therapy. Clin Infect Dis 2012; epub ahead of print.
6. Lawn S D, Kerkhoff A D, Vogt M, Wood R. Diagnostic accuracy of a low-cost, urine antigen, point-of-care screening assay for HIV-associated pulmonary tuberculosis before antiretroviral therapy: a descriptive study. Lancet Infect Dis 2012; 12: 201-209.