Novel approaches to improve the therapeutic index of head and neck radiotherapy: An analysis of data from the PARSPORT randomised phase III trial

Radiotherapy and Oncology

Volumn 103, Issue 1, 2012, Pages 82-87

  Buettner, Florian ^a   Miah, Aisha B ^a   Gulliford, Sarah L ^a   Hall, Emma ^b   Harrington, Kevin J ^a   Webb, Steve ^a   Partridge, Mike ^a   Nutting, Christopher M ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Dose effect relation; Head and neck cancer; Parotid glands; Radiotherapy

Indexed keywords

ACCURACY; ADULT; AGED; ALGORITHM; ARTICLE; CANCER PATIENT; CANCER RADIOTHERAPY; DATA ANALYSIS; FEMALE; HEAD AND NECK CANCER; HUMAN; MAJOR CLINICAL STUDY; MALE; PAROTID GLAND; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RADIOSENSITIVITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RELIABILITY; RISK ASSESSMENT; SUBMANDIBULAR GLAND; TREATMENT PLANNING; VALIDATION PROCESS; XEROSTOMIA;

ADULT; AGED; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; PAROTID GLAND; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED; XEROSTOMIA;

EID: 84859698668     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.02.006     Document Type: Article

References (28)

1. Goitein M. How best to dispose of extra-tumoral dose: a cautionary note for intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys 2009;75:1-3.
2. Deasy JO, Moiseenko V, Marks L, Chao KSC, Nam J, Eisbruch A. Radiotherapy dose-volume effects on salivary gland function. Int J Radiat Oncol Biol Phys 2010;76:S58-63.
3. Strigari L, Benassi M, Arcangeli G, Bruzzaniti V, Giovinazzo G, Marucci L. A novel dose constraint to reduce xerostomia in head-and-neck cancer patients treated with intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2010;77:269-76.
4. Dirix P, Nuyts S. Evidence-based organ-sparing radiotherapy in head and neck cancer. Lancet Oncol 2010;11:85-91.
5. Nutting CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, et al. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol 2011;12:127-36.
6. Konings AWT, Cotteleer F, Faber H, van Luijk P, Meertens H, Coppes RP. Volume effects and region-dependent radiosensitivity of the parotid gland. Int J Radiat Oncol Biol Phys 2005;62:1090-5. (Pubitemid 40884422)
7. Dijkema T, Terhaard CHJ, Roesink JM, Braam PM, van Gils CH, Moerland MA, et al. Large cohort dose-volume response analysis of parotid gland function after radiotherapy: intensity-modulated versus conventional radiotherapy. Int J Radiat Oncol Biol Phys 2008;72:1101-9.
8. van Luijk P, Bijl HP, Konings AWT, van der Kogel AJ, Schippers JM. Data on dose-volume effects in the rat spinal cord do not support existing NTCP models. Int J Radiat Oncol Biol Phys 2005;61:892-900. (Pubitemid 40247988)
9. van Luijk P, Faber H, Schippers JM, Brandenburg S, Langendijk JA, Meertens H, et al. Bath and shower effects in the rat parotid gland explain increased relative risk of parotid gland dysfunction after intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2009;74:1002-5.
10. Houweling AC, Philippens MEP, Dijkema T, Roesink JM, Terhaard CHJ, Schilstra C, et al. A comparison of dose-response models for the parotid gland in a large group of head-and-neck cancer patients. Int J Radiat Oncol Biol Phys 2010;76:1259-65.
11. van Holten MJ, Roesink JM, Terhaard CHJ, Braam PM. New insights in the vascular supply of the human parotid gland - consequences for parotid glandsparing irradiation. Head Neck 2010;32:837-43.
12. Urbano MTG, Clark CH, Kong C, Miles E, Dearnaley DP, Harrington KJ, et al. Target volume definition for head and neck intensity modulated radiotherapy: pre-clinical evaluation of PARSPORT trial guidelines. Clin Oncol (R Coll Radiol) 2007;19:604-13.
13. Clark CH, Hansen VN, Chantler H, Edwards C, James HV, Webster G, et al. Dosimetry audit for a multi-centre IMRT head and neck trial. Radiother Oncol 2009;93:102-8.
14. Lent soma tables. Radiother Oncol 1995:35:17-60.
15. Bentzen SM, Constine LS, Deasy JO, Eisbruch A, Jackson A, Marks LB, et al. Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys 2010;76:S3-9.
16. Nixon M, Aguado AS. Feature extraction & image processing. 2nd ed. Academic Press; 2008. ISBN 0123725380.
17. Nikolaidis N, Pitas I. 3-D image processing algorithms. New York: John Wiley; 2001.
18. Buettner F, Gulliford S, Webb S, Partridge M. Using a Bayesian feature-selection algorithm to identify dose-response models based on the shape of the 3D dose-distribution: an example from a head-and-neck cancer trial. In: Proceedings of the ninth international conference on machine learning and applications, 2010.
19. Eisbruch A, Haken RKT, Kim HM, Marsh LH, Ship JA. Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys 1999;45:577-87. (Pubitemid 29462636)
20. Blanco AI, Chao KSC, Naqa IE, Franklin GE, Zakarian K, Vicic M, et al. Dose-volume modeling of salivary function in patients with head-andneck cancer receiving radiotherapy. Int J Radiat Oncol Biol Phys 2005;62: 1055-69. (Pubitemid 40884418)
21. Barnett GC, Meerleer GD, Gulliford SL, Sydes MR, Elliott RM, Dearnaley DP. The impact of clinical factors on the development of late radiation toxicity: results from the medical research council RT01 trial (ISRCTN47772397). Clin Oncol (R Coll Radiol) 2011;23:613-24.
22. Lunn DJ, Whittaker JC, Best N. A Bayesian toolkit for genetic association studies. Genet Epidemiol 2006;30:231-47.
23. Lunn DJ, Best N, Whittaker JC. Generic reversible jump MCMC using graphical models. Stat Comput 2009;19:395-408.
24. Miah A, Bhide S, Guerrero-Urbano M, Newbold K, Harrington K, Nutting C. Intensity modulated radiotherapy (IMRT) for nasopharyngeal cancers - acute toxicities and treatment outcomes. Radiother Oncol 2009;92:S107.
25. Miah A, Gulliford S, Harrington K, Bhide S, Newbold K, Nutting C. Recovery of salivary gland toxicity: contralateral parotid gland (PG) sparing versus bilateral superficial lobes parotid sparing IMRT (PARSPORT versus PARSPORT II). Radiother Oncol 2011;99:519.
26. Miah A, Bhide S, Guerrero-Urbano M, Clark C, Newbold K, Harrington K, et al. Bilateral superficial parotid gland sparing IMRT produces similar long-term xerostomia scores when compared to unilateral parotid sparing IMRT in midline head and neck squamous cell cancers (HNSCC). Int J Radiat Oncol Biol Phys 2009;3:S401.
27. Buettner F. On the relevance of the spatial distribution of dose in organs-atrisk for complications after radiotherapy. Ph.D. thesis. The Institute of Cancer Research, University of London, UK; 2011.
28. Dhiwakar M, Ronen O, Malone J, Rao K, Bell S, Phillips R, et al. Feasibility of submandibular gland preservation in neck dissection: a prospective anatomic- pathologic study. Head Neck 2011;33:603-9.