HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers

Virology Journal

Volumn 2, Issue , 2005, Pages

  León, Bernal ^a   Taylor, Lizeth ^a   Vargas, Minor ^b   Luftig, Ronald B ^d   Albertazzi, Federico ^c   Herrero, Libia ^c   Visona, Kirsten ^a  

^a Louisiana State University ICMRT LSU   (Costa Rica)

^b Hospital San Juan de Dios   (Costa Rica)

^c UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^d LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; PROTEIN M130K; PROTEIN V131I; THREONINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE COURSE; FOLLOW UP; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HETEROZYGOTE; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYMERASE CHAIN REACTION; SEROLOGY;

HEPATITIS B VIRUS;

EID: 84859674409     PISSN: 1743422X     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-2-60     Document Type: Article

References (34)

1. Beasley RP, Hwang LY, Lin CC, Chien CS: Hepatocelullar carcinoma and hepatitis B virus: a prospective study of 22707 men in Taiwan. Lancet 1981, 2:1129-33.
2. Bergametti F, Sitterlin D, Transy C: Turnover of Hepatitis B Virus X protein is regulated by a Damaged DNA-Binding Complex. J Virol 2002, 76:6495-6501.
3. Lee H, Yun Y: HBx protein of Hepatitis B virus activates Jak1-STAT signaling. J Biol Chem 1998, 273:25510-25515.
4. Chun YK, Kim JY, Woo HJ, Oh SM, Kang I, Ha J, Kim SS: No significant correlation exist between core promoter mutations, viral replication and liver damage in chronic hepatitis B infection. Hepatology 2000, 32:1154-1162.
5. Buckwold VE, Xu Z, Chen M, Yen TS, Ou JH: Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 1996, 70:5845-5851.
6. Horikita M, Itoh S, Yamamoto K, Shibayama T, Tsuda F, Okamoto H: Differences in the entire nucleotide sequence between hepatitis B virus genomes from carriers positive for antibody to hepatitis B e antigen with and without active disease. J Med Virol 1994, 44:96-103.
7. Sallam TA, Tong CY: Two distinct types of hepatitis B virus core promoter variants in Yemeni blood donors. J Med Virol 2002, 68:328-34.
8. Schlager F, Schaefer S, Metzler M, Gratzki N, Lampert F, Gerlich WH, Repp R: Quantitative DNA fragment analysis for detecting low amounts of hepatitis B virus deletion mutants in highly viremic carriers. Hepatology 2000, 32:1096-105.
9. Preikschat P, Gunther S, Reinhold S, Will H, Budde K, Neumayer H, Kruger DH, Meisel H: Complex HBV populations with mutations in core promoter, C gene and Pre S region are associated with development of cirrhosis in long-term renal transplant recipients. Hepatology 2002, 35:466-477.
10. Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Brechot C: Hepatitis B Virus X mutants, present inhepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 1999, 26:4848-59.
11. Hsia CC, Yuwen H, Tabor E: Hot spot mutations in hepatitis B virus X gene in hepatocelullar carcinoma. Lancet 1996, 348:625-626.
12. Fang ZL, Ling R, Wang SS, Nong J, Huang CS, Harrison TJ: HBV core promoter mutations prevail in patients with hepatocellular carcinoma in Guangxi, China. J Med Virol 1998, 56:18-24.
13. Batista M, Kramvis A, Kew M: High prevalence of 1672T 1764G mutations in the basic core promoter of Hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology 1999, 29:946-953.
14. Lindh M, Hannoun C, Dhillon AP, Norkrans G, Horal P: Core Promoter Mutations and Genotypes in Relation to Viral Replication and Liver Damage in East Asian Hepatitis B Virus Carriers. J Inf Dis 1999, 179:775-82.
15. Norder H, Hammas B, Lee SD, Courouce AM, Mushahwar IK, Magnius L: Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen. J Gen Virol 1993, 74:1341-1348.
16. Norder H, Courouce AM, Magnius LO: Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 1994, 218:214-223.
17. Arauz-Ruiz P, Norder H, Robertson BH, Magnius L: Genotype H: a new American genotype of hepatitis B virus revealed in Central America. J Gen Virol 2002, 83:2059-2073.
18. Arauz-Ruiz P, Norder H, Visoná K, Magnius L: Genotype F prevails in HBV infected patients of Hispanic origin in Central America and may carry the precore stop mutant. J Med Virol 1997, 51:305-312.
19. Visoná K, Eduarte C, Zamora E, Salazar L: Estudio epidemiológico de las hepatitis virales en San Ramón y Palmares de 1972-1985. Acta Médica Costarricense 1989, 33:69-77.
20. Honda A, Yokusaka O, Suzuki K, Saisho H: Detection of mutations in hepatitis B virus enhancer 2/core promoter and x protein regions in patients with fatal hepatitis B virus infection. J Med Virol 2000, 62:167-176.
21. Kobayashi M, Arase Y, Ikeda K, Tsubota A, Suzuki Y, Saitoh S, Kobayashi M, Suzuki F, Akutas N, Hosaka T, Someya T, Matsuda M, Sato J, Miyakawa Y, Kumada H: Wild type precore and core promoter sequences in patients with acute self limited or chronic Hepatitis B. Scand Journal Gastroenterol 2004, 1:53-59.
22. Cho SW, Shin YJ, Hahm KB, Jin JH, Kim YS, Kim HJ: Analysis of the precore and core promoter DNA Sequence in liver tissues from patients with Hepatocellular carcinoma. J Korean Med 1999, 14:424-30.
23. 1764 A) and viral genotype in chronic hepatitis B and hepatocellular carcinoma in Guangxi, China. J Med Virol 2002, 68:33-40.
24. Ni YH, Chang MH, Hsu HY, Tsuei DJ: Longitudinal study on mutation profilies of core promoter and precore regions of the hepatitis B virus genome in children. Ped Res 2004, 56:396-399.
25. Vernard V, Corsaro D, Kajzer C, Bronowicki J, Faou A: Hepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinoma. J Med Virol 2000, 62:177-184.
26. Hannoun C, Horal P, Lindh M: Long -term mutation rates in the hepatitis B virus genome. J Gen Virol 2000, 81:75-83.
27. Bläckberg J, Kidd-Ljunggren K: Mutations within the hepatitis B virus genome among hepatitis B patients with Hepatocellular carcinoma. J Med Virol 2003, 71:18-23.
28. Gandhe SS, Chadha MS, Walimbe AW, Arankalle VA: Hepatitis B virus: prevalence of precore/core promoter mutants in different clinical categories of indian patients. Viral Hepatitis 2003, 10:367-382.
29. Li KS, Yamashiro T, Sumie A, Terao H, Mifune K, Nishizono A: Hepatitis B virus harboring nucleotide deletions in the core promoter region and genotype B correlate with low viral replication activity in anti-HBe positive carriers. J Clin Virol 2001, 23:97-106.
30. Kuang SY, Jackson PE, Wang JB, Lu PX, Munoz A, Qian GS, Kensler TW, Groopman JD: Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proc Natl Acad Sci U S A 2004, 101:3575-80.
31. Palacios A, Taylor L, Haue L, Luftig RB, Visona KA: Development of low cost peptide-based anti-Hepatitis C virus screening and confirmatory assays: Comparison with commercially available tests. J Med Virol 1999, 58:221-226.
32. Peters RL: Hepatocellular carcinoma Volume Chapter 8. Edited by: Okuda K, Peters RL. John Wiley; 1976.
33. Altschul SF, Gish W, Miller W, Myers E, Lipman D: Basic local alignment search tool. J Mol Biol 1990, 215:403-410.
34. Rozanov M, Plikat U, Chappey C, Kochergin A, Tatusova TA: Web-based genotyping resource for viral sequences. Nucleic Acids Research 2004, 32(Web Server):w654-659.