Commentary: Gärtner's 'third component': Still an open question

International Journal of Epidemiology

Volumn 41, Issue 2, 2012, Pages 356-358

  Oey, Harald ^a   Whitelaw, Emma ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BODY WEIGHT; EMBRYO CELL; ENVIRONMENT; EPIGENETICS; EXPERIMENTAL ANIMAL; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; INBREEDING; NONHUMAN; NOTE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PUBLICATION; STANDARDIZATION; TWINS; ZYGOTE;

ANIMALS; ANIMALS, LABORATORY; BODY WEIGHT; ENVIRONMENT; GENETIC VARIATION; GENOTYPE; MALE; QUANTITATIVE TRAIT LOCI;

EID: 84859648108     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dys009     Document Type: Note

References (16)

1. Gärtner K. A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals? Lab Anim 1990;24:71-77; Reprinted Int J Epidemiol 2012;41:335-41.
2. Falconer DS. Introduction to Quantitative Genetics. Edinburgh/London: Oliver & Boyd, 1960.
3. Gärtner K, Baunack E. Is the similarity of monozygotic twins due to genetic factors alone? Nature 1981;292: 646-47.
4. Vogt G, Huber M, Thiemann M, van den Boogaart G, Schmitz OJ, Schubart CD. Production of different phenotypes from the same genotype in the same environment by developmental variation. J Exp Biol 2008;211: 510-23.
5. Blewitt ME, Chong S, Whitelaw E. How the mouse got its spots. Trends Genet 2004;20:550-54.
6. Wong AH, Gottesman II, Petronis A. Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 2005;14(Spec No 1): R11-18.
7. Kipling D, Cooke HJ. Hypervariable ultra-long telomeres in mice. Nature 1990;347:400-2.
8. Starling JA, Maule J, Hastie ND, Allshire RC. Extensive telomere repeat arrays in mouse are hypervariable. Nucleic Acids Res 1990;18:6881-88.
9. Roberts AR, Blewitt ME, Youngson NA, Whitelaw E, Chong S. Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo. Chromosoma 2011;120:377-85.
10. Linardopoulou E, Mefford HC, Nguyen O et al. Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location. Hum Mol Genet 2001;10: 2373-83.
11. Riethman H, Ambrosini A, Castaneda C et al. Mapping and initial analysis of human subtelomeric sequence assemblies. Genome Res 2004;14:18-28.
12. Pedram M, Sprung CN, Gao Q, Lo AW, Reynolds GE, Murnane JP. Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol 2006;26:1865-78.
13. Gao Q, Reynolds GE, Innes L et al. Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells. Stem Cells 2007;25:3085-92.
14. She X, Cheng Z, Zöllner S, Church DM, Eichler EE. Mouse segmental duplication and copy number variation. Nat Genet 2008;40:909-14.
15. Watkins-Chow DE, Pavan WJ. Genomic copy number and expression variation within the C57BL/6J inbred mouse strain. Genome Res 2008;18:60-66.
16. Baillie JK, Barnett MW, Upton KR et al. Somatic retrotransposition alters the genetic landscape of the human brain. Nature 2011;479:534-37.