Evaluation of TNF-α and IL-6 levels in obese and non-obese diabetics: Pre- and postinsulin effects

North American Journal of Medical Sciences

Volumn 4, Issue 4, 2012, Pages 180-184

  Goyal, Rajeev ^a   Faizy, Abul Faiz ^b   Siddiqui, Sheelu S ^b   Singhai, Monil ^a  

^a Government Medical College   (India)

^b ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

Diabetes; Inlammation; Obesity

Indexed keywords

INSULIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIABETIC OBESITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; HUMAN; INFLAMMATION; INSULIN TREATMENT; MARKER; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROSPECTIVE STUDY;

EID: 84859647350     PISSN: None     EISSN: 19472714     Source Type: Journal    
DOI: 10.4103/1947-2714.94944     Document Type: Article

References (18)

1. Kahn CR. Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 1994;43:1066-84.
2. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, et al. Adipocyte death deines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005;46:2347-55.
3. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-808.
4. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 1993;259:87-91.
5. Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: A key component of the obesity-diabetes link. Diabetes 1994;43:1271-8.
6. Dandona P, Chaudhuri A, Ghanim H, Mohanty P. Antiinlammatory effects of insulin and the pro-inlammatory effects of glucose. Semin Thorac Cardiovasc Surg 2006;18:293-301.
7. Pickup JC, Mattock MB, Chusney GD, Burt D. NIDDM as a disease of the innate immune system: Association of acutephase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 1997;40:1286-92.
8. Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998;41:1241-8.
9. Gauldie J, Richards C, Harnish D, Lansdorp P, Baumann H. Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci USA 1987;84:7251-5.
10. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inlammation. N E ngl J M ed 1999;340:448-54.
11. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001;286:327-34.
12. Ray A, Huisman MV, Tamsma JT, van Asten J, Bingen BO, Broeders EA, et al. The role of inlammation on atherosclerosis, intermediate and clinical cardiovascular endpoints in type 2 diabetes mellitus. Eur J Intern Med 2009;20:253-60.
13. Mirza S, Hossain M, Mathews C, Martinez P, Pino P, Gay JL, et al. Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: A cross-sectional study. Cytokine 2012;57:136-42.
14. Rajarajeswari D, Ramalingam K, Krishnamma M, Krishna TS. Association of TNF-α with obesity in type2- diabetes mellitus. Int J Pharm Biol Sci 2011;2 (2):352-7.
15. Coppack S. Pro-inlammatory cytokines and adipose tissue. Proc Nutr Soc 2001;60:349-56.
16. Dandona P, Aljada A, Bandyopadhyay A. Inlammation: The link between insulin resistance, obesity and diabetes. Trends Immunol 2004;25:4-7.
17. Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: Antiinlammatory and immunosuppressive mediators. Immunol Today 1997;18:428-32.
18. Bullo M, Garcia-Lorda P, Megias I, Salas-Salvado J. Systemic inlammation, adipose tissue tumor necrosis factor and leptin expression. Obes Res 2003;11:525-31.