-
1
-
-
78751621217
-
Evolving epidemiology of hepatitis C virus
-
Lavanchy D. Evolving epidemiology of hepatitis C virus, Clin Microbiol Infect. 2011; 17(2):107-15
-
(2011)
Clin Microbiol Infect
, vol.17
, Issue.2
, pp. 107-115
-
-
Lavanchy, D.1
-
2
-
-
0004016899
-
-
Fact sheet N0164 June Available from: Accessed January 2012
-
Hepatitis C. World Health Organization. Fact sheet N0164 June 2011. Available from: http://www.who.int/mediacentre/factsheets/fs164/en/index.html [Accessed January 2012]
-
(2011)
Hepatitis C
-
-
-
3
-
-
33748288279
-
Hepatitis C virus therapies
-
DOI 10.1038/nrd2134, PII NRD2134
-
Smith RE. Hepatitis C virus therapies. Nat Rev Drug Discov 2006;5:715-16 (Pubitemid 44323697)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 715-716
-
-
Smith, R.E.T.1
-
5
-
-
79851470805
-
Interferon in the treatment of chronic hepatitis C: A drug caught between past and future
-
Vezali E, Aghemo A, Colombo M. Interferon in the treatment of chronic hepatitis C: a drug caught between past and future. Expert Opin Biol Ther 2011;11(3):301-13
-
(2011)
Expert Opin Biol Ther
, vol.11
, Issue.3
, pp. 301-313
-
-
Vezali, E.1
Aghemo, A.2
Colombo, M.3
-
6
-
-
81855190655
-
Advances in hepatitis C virus vaccines, part one: Advances in basic knowledge for hepatitis C virus vaccine design
-
This article reviews the cutting edge advances of basic knowledge and novel study tools on HCV for targeted design and evaluation of efficient HCV vaccines
-
Roohvand F, Kossari N. Advances in hepatitis C virus vaccines, part one: advances in basic knowledge for hepatitis C virus vaccine design. Expert Opin Ther Patents 2011;21(12):1811-30 This article reviews the cutting edge advances of basic knowledge and novel study tools on HCV for targeted design and evaluation of efficient HCV vaccines.
-
(2011)
Expert Opin Ther Patents
, vol.21
, Issue.12
, pp. 1811-1830
-
-
Roohvand, F.1
Kossari, N.2
-
7
-
-
79958804426
-
Vaccines: A moving target
-
This article provides a short but elegant summary on several HCV vaccine candidates in the phase I/II of clinical trials
-
Eisenstein M. Vaccines: a moving target. Nature 2011;8:474(7350):S16-17 This article provides a short but elegant summary on several HCV vaccine candidates in the phase I/II of clinical trials.
-
(2011)
Nature
, vol.8-474
, Issue.7350
-
-
Eisenstein, M.1
-
8
-
-
81855199089
-
Nucleic acid construct containing full-length genome of human Hepatitis C virus, recombinant full-length virus genome replicative cell having the nucleic acid construct transferred thereinto and method of constructing hepatitis C viral particles
-
Tokyo Metropolitan Org Med Res and Toray Industries. WO2005080575; This patent describes the innovative invention of the first efficient HCV (JFH1) culture system for robust production of viral particles
-
Tokyo Metropolitan Org Med Res and Toray Industries. Nucleic acid construct containing full-length genome of human Hepatitis C virus, recombinant full-length virus genome replicative cell having the nucleic acid construct transferred thereinto and method of constructing hepatitis C viral particles. WO2005080575; 2005 This patent describes the innovative invention of the first efficient HCV (JFH1) culture system for robust production of viral particles.
-
(2005)
-
-
-
9
-
-
81855163735
-
Composition comprising specific non-structural proteins of hepatitis C virus, useful as prophylactic or therapeutic vaccines, also related expression vectors, microorganisms and antibodies
-
Biomerieux SA, Inst Nat Sante Rech Med. FR2855758
-
Biomerieux SA, Inst Nat Sante Rech Med. Composition comprising specific non-structural proteins of hepatitis C virus, useful as prophylactic or therapeutic vaccines, also related expression vectors, microorganisms and antibodies. FR2855758; 2004
-
(2004)
-
-
-
10
-
-
81855218456
-
Hepatitis C Virus Asialoglycoproteins
-
Chiron Corp. WO9533053
-
Chiron Corp. Hepatitis C Virus Asialoglycoproteins. WO9533053; 1995
-
(1995)
-
-
-
11
-
-
81855218455
-
Novel Hepatitis C E1 and E2 Truncated Polypeptides and Methods of obtaining the same
-
Chiron Corp. WO9604301
-
Chiron Corp. Novel Hepatitis C E1 and E2 Truncated Polypeptides and Methods of obtaining the same. WO9604301; 1996
-
(1996)
-
-
-
12
-
-
51349118197
-
New views on immunopotentiators in modern vaccines
-
This review summarizes novel vaccine adjuvants/carriers for human applications
-
Schijns V, Brewer MJ. New views on immunopotentiators in modern vaccines. Expert Rev Vaccines 2008;7(7):877-9 This review summarizes novel vaccine adjuvants/carriers for human applications.
-
(2008)
Expert Rev Vaccines
, vol.7
, Issue.7
, pp. 877-879
-
-
Schijns, V.1
Brewer, M.J.2
-
13
-
-
79953216363
-
Hepatitis C virus soluble E2 in combination with QuilA and CpG ODN induces neutralizing antibodies in mice
-
Naarding MA, Falkowska E, Xiao H, et al. Hepatitis C virus soluble E2 in combination with QuilA and CpG ODN induces neutralizing antibodies in mice. Vaccine 2011;29(16):2910-17
-
(2011)
Vaccine
, vol.29
, Issue.16
, pp. 2910-2917
-
-
Naarding, M.A.1
Falkowska, E.2
Xiao, H.3
-
14
-
-
84859639556
-
Adjuvant formulation comprising a submicron oil droplet emulsion
-
Chiron Corp. WO9014837
-
Chiron Corp. Adjuvant formulation comprising a submicron oil droplet emulsion. WO9014837; 1990
-
(1990)
-
-
-
15
-
-
84859650141
-
Recombinant Dna Derived Cholera Toxin Subunit Analogs
-
Amgen, Inc. and Univ Southern California. WO9219265
-
Amgen, Inc. and Univ Southern California. Recombinant Dna Derived Cholera Toxin Subunit Analogs. WO9219265; 1992
-
(1992)
-
-
-
16
-
-
84859640530
-
Microparticles with adsorbent surfaces, methods of making same, and uses thereof
-
Chiron Corp. US6884435
-
Chiron Corp. Microparticles with adsorbent surfaces, methods of making same, and uses thereof. US6884435; 2005
-
(2005)
-
-
-
17
-
-
84859639555
-
Hepatitis Vaccines Containing 3-O-Deacylated Monophoshoryl Lipid A
-
Smithkline Beecham Biolog. WO9319780
-
Smithkline Beecham Biolog. Hepatitis Vaccines Containing 3-O-Deacylated Monophoshoryl Lipid A. WO9319780; 1993
-
(1993)
-
-
-
18
-
-
84859639559
-
Novel (Adjuvant) Compositions (For Vaccines)
-
Smithkline Beecham Biolog. WO9857659; 1998 and WO200117550
-
Smithkline Beecham Biolog. Novel (Adjuvant) Compositions (For Vaccines). WO9857659; 1998 and WO200117550; 2001
-
(2001)
-
-
-
19
-
-
84859649726
-
Oil in water vaccine compositions
-
Smithkline Beecham Biolog. WO9856414
-
Smithkline Beecham Biolog. Oil in water vaccine compositions. WO9856414; 1998
-
(1998)
-
-
-
20
-
-
84859648350
-
Vaccines
-
Smithkline Beecham Biolog. WO9517210
-
Smithkline Beecham Biolog. Vaccines. WO9517210; 1995
-
(1995)
-
-
-
21
-
-
84859639560
-
Vaccines Against Hepatitis C
-
Smithkline Beecham Biolog. WO9701640
-
Smithkline Beecham Biolog. Vaccines Against Hepatitis C. WO9701640; 1997
-
(1997)
-
-
-
22
-
-
84859641989
-
Vaccine Compositions Containing 3-O Deacylated Monophosphoryl Lipid A
-
Smithkline Beecham Biolog. WO9421292
-
Smithkline Beecham Biolog. Vaccine Compositions Containing 3-O Deacylated Monophosphoryl Lipid A. WO9421292; 1994
-
(1994)
-
-
-
23
-
-
67649424447
-
Oil in water emulsions containing saponins
-
Smithkline Beecham Biologicals. WO199911241
-
Smithkline Beecham Biologicals. Oil in water emulsions containing saponins. WO199911241; 1999
-
(1999)
-
-
-
24
-
-
84859629476
-
Method of encapsulating biologically active materials in lipid vesicles
-
US4235871
-
Papahadjopoulos DP, Szoka FC. Method of encapsulating biologically active materials in lipid vesicles. US4235871; 1980
-
(1980)
-
-
Papahadjopoulos, D.P.1
Szoka, F.C.2
-
25
-
-
0242700436
-
Liposomes with enhanced circulation time
-
Liposome Technology, Inc. US4837028
-
Liposome Technology, Inc. Liposomes with enhanced circulation time. US4837028; 1989
-
(1989)
-
-
-
26
-
-
67649440775
-
Use of an amphipathic compound for providing an adjuvant to a subunit vaccine
-
Aventis Pasteur. US6472159
-
Aventis Pasteur. Use of an amphipathic compound for providing an adjuvant to a subunit vaccine. US6472159; 2002
-
(2002)
-
-
-
27
-
-
67649421296
-
Vaccines with enhanced immune response and methods for their preparation
-
Immunovaccine Technologies, Inc. US2002110568
-
Immunovaccine Technologies, Inc. Vaccines with enhanced immune response and methods for their preparation. US2002110568; 2002
-
(2002)
-
-
-
28
-
-
49749110778
-
A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection
-
Chua BY, Eriksson EM, Brown LE, et al. A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection. Vaccine 2008;26(37):4866-75
-
(2008)
Vaccine
, vol.26
, Issue.37
, pp. 4866-4875
-
-
Chua, B.Y.1
Eriksson, E.M.2
Brown, L.E.3
-
29
-
-
22144434860
-
Immunogenicity and tolerability of intradermal administration of an HCV E1-based vaccine candidate in healthy volunteers and patients with resolved or ongoingchronic HCV infection
-
This article provides results of a phase I study on one of the first subunit vaccines prepared against HCV infection
-
Leroux-Roels G, Batens AH, Desombere I, et al. Immunogenicity and tolerability of intradermal administration of an HCV E1-based vaccine candidate in healthy volunteers and patients with resolved or ongoingchronic HCV infection. Hum Vaccin 2005;1(2):61-5 This article provides results of a phase I study on one of the first subunit vaccines prepared against HCV infection.
-
(2005)
Hum Vaccin
, vol.1
, Issue.2
, pp. 61-65
-
-
Leroux-Roels, G.1
Batens, A.H.2
Desombere, I.3
-
30
-
-
79956115037
-
Factors influencing progression of liver fibrosis in patients with chronic hepatitis C: Results of the 3-year T2S-918-HCV study with HCVE1 therapeutic vaccine
-
Wedemeyer H, Mazur W, Nevens F. Factors influencing progression of liver fibrosis in patients with chronic hepatitis C: results of the 3-year T2S-918-HCV study with HCVE1 therapeutic vaccine. J Hepatol 2008;48:S27-8
-
(2008)
J Hepatol
, vol.48
-
-
Wedemeyer, H.1
Mazur, W.2
Nevens, F.3
-
31
-
-
80052186961
-
Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies
-
Verstrepen BE, Depla E, Rollier CS, et al. Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies. J Infect Dis 2011;204(8):37-44
-
(2011)
J Infect Dis
, vol.204
, Issue.8
, pp. 37-44
-
-
Verstrepen, B.E.1
Depla, E.2
Rollier, C.S.3
-
32
-
-
81855218448
-
HCV E1E2 vaccine compositions
-
Chiron Corp. US2009258033
-
Chiron Corp. HCV E1E2 vaccine compositions. US2009258033; 2009
-
(2009)
-
-
-
33
-
-
81855199083
-
NANBV diagnostics and vaccines
-
Chiron Corp. US6346375
-
Chiron Corp. NANBV diagnostics and vaccines. US6346375; 2002
-
(2002)
-
-
-
34
-
-
23944452579
-
Prospects for a vaccine against the hepatitis C virus
-
DOI 10.1038/nature04081
-
Houghton M, Abrignani S. Prospects for a vaccine against the hepatitis C virus. Nature 2005;436:961-6 (Pubitemid 41191672)
-
(2005)
Nature
, vol.436
, Issue.7053
, pp. 961-966
-
-
Houghton, M.1
Abrignani, S.2
-
35
-
-
84859650147
-
-
ClinicalTrials.gov Identifier: NCT00500747. Available from Accessed on January 2012 This web site provides the results of the phase I studies on HCV MF59 + r*E1/E2 vaccine
-
ClinicalTrials.gov Identifier: NCT00500747. Available from: http://clinicaltrials.gov/ct2/show/results/NCT00500747 [Accessed on January 2012] This web site provides the results of the phase I studies on HCV MF59 + r*E1/E2 vaccine.
-
-
-
-
36
-
-
77955661037
-
Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults
-
This article provides results of a phase I study on E1E2+ MF59 subunit vaccine
-
Frey SE, Houghton M, Coates S, et al. Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults. Vaccine 2010;28(38):6367-73 This article provides results of a phase I study on E1E2+ MF59 subunit vaccine.
-
(2010)
Vaccine
, vol.28
, Issue.38
, pp. 6367-6373
-
-
Frey, S.E.1
Houghton, M.2
Coates, S.3
-
37
-
-
84859648556
-
Matrix with Immunomodulating Activity
-
US5679354
-
Morein B. Matrix With Immunomodulating Activity. US5679354; 1997
-
(1997)
-
-
Morein, B.1
-
38
-
-
4243526706
-
Immunogenic complexes and methods relating there to
-
CSL Ltd. WO200048630
-
CSL Ltd. Immunogenic complexes and methods relating there to. WO200048630; 2000
-
(2000)
-
-
-
39
-
-
0025310910
-
Induction of CD81 cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs
-
Takahashi HT, Takeshita B, Morein S, et al. Induction of CD81 cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs. Nature 1990;344:873
-
(1990)
Nature
, vol.344
, pp. 873
-
-
Takahashi, H.T.1
Takeshita, B.2
Morein, S.3
-
40
-
-
0344197071
-
The major Epstein-Barr virus (EBV) envelope glycoprotein gp340 when incorporated into ISCOMs primes cytotoxic T-cell responses directed against EBV lymphoblastoid cell lines
-
Wilson ADK, Lovgren-Bengtsson M, Villacres-Ericsson B, et al. The major Epstein-Barr virus (EBV) envelope glycoprotein gp340 when incorporated into ISCOMs primes cytotoxic T-cell responses directed against EBV lymphoblastoid cell lines. Vaccine 1999;17:1282
-
(1999)
Vaccine
, vol.17
, pp. 1282
-
-
Wilson, A.D.K.1
Lovgren-Bengtsson, M.2
Villacres-Ericsson, B.3
-
41
-
-
4244005466
-
Chelating Immunostimulating Complexes
-
Csl Ltd. WO9836772
-
Csl Ltd. Chelating Immunostimulating Complexes. WO9836772; 1998
-
(1998)
-
-
-
42
-
-
67649336398
-
ISCOMs and ISCOMATRIX
-
This article provides a detailed description on different aspect of ISCOMs as adjuvants
-
Sun HX, Xie Y, Ye YP. ISCOMs and ISCOMATRIX. Vaccine 2009;27(33):4388-401 This article provides a detailed description on different aspect of ISCOMs as adjuvants.
-
(2009)
Vaccine
, vol.27
, Issue.33
, pp. 4388-4401
-
-
Sun, H.X.1
Xie, Y.2
Ye, Y.P.3
-
43
-
-
81855191796
-
Vaccine Compositions
-
Csl Ltd. and Chiron Corp. US2010047271
-
Csl Ltd. and Chiron Corp. Vaccine Compositions. US2010047271; 2010
-
(2010)
-
-
-
44
-
-
0022459165
-
Pinocytosis and phagocytosis: The effect of size of a particulate substrate on its mode of capture by rat peritoneal macrophages cultured in vitro
-
Pratten MK, Lloyd JB. Pinocytosis and phagocytosis: the effect of size of a particulate substrate on its mode of capture by rat peritoneal macrophages cultured in vitro. Biochim Biophys Acta 1986;881:307
-
(1986)
Biochim Biophys Acta
, vol.881
, pp. 307
-
-
Pratten, M.K.1
Lloyd, J.B.2
-
45
-
-
0035284757
-
Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine
-
Polakos N, Drane D, Cox J, et al. Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine. J Immunol 2001;166:3589-98 (Pubitemid 33117365)
-
(2001)
Journal of Immunology
, vol.166
, Issue.5
, pp. 3589-3598
-
-
Polakos, N.K.1
Drane, D.2
Cox, J.3
Ng, P.4
Selby, M.J.5
Chien, D.6
O'Hagan, D.T.7
Houghton, M.8
Paliard, X.9
-
46
-
-
67549123833
-
Priming of CD4+ and CD8+ T cell responses using a HCV core ISCOMATRIX vaccine. A phase I study in healthy volunteers
-
This article provides results of a phase I study on core+ISCOMATRIX vaccine subunit vaccine
-
Drane D, Maraskovsky E, Gibson R, et al. Priming of CD4+ and CD8+ T cell responses using a HCV core ISCOMATRIX vaccine. A phase I study in healthy volunteers. Hum Vaccin 2009;5(3):151-7 This article provides results of a phase I study on core+ISCOMATRIX vaccine subunit vaccine.
-
(2009)
Hum Vaccin
, vol.5
, Issue.3
, pp. 151-157
-
-
Drane, D.1
Maraskovsky, E.2
Gibson, R.3
-
47
-
-
77951596275
-
Chitosan enhancement of immune responses
-
United States Dept. of Health and Human Services, US. WO2008039390
-
United States Dept. of Health and Human Services, US. Chitosan enhancement of immune responses. WO2008039390; 2008
-
(2008)
-
-
-
48
-
-
77951540215
-
Therapeutic and vaccine polyelectrolyte nanoparticle compositions
-
Aparna Biosciences, USA. WO2009079066
-
Aparna Biosciences, USA. Therapeutic and vaccine polyelectrolyte nanoparticle compositions. WO2009079066; 2009
-
(2009)
-
-
-
49
-
-
84859644777
-
Pharmaceutical Compositions Enhancing the Immunogenicity of Poorly Immunogenic Antigens
-
Ct De Immunologia Molecular. EA2003000064020011206
-
Ct De Immunologia Molecular. Pharmaceutical Compositions Enhancing the Immunogenicity of Poorly Immunogenic Antigens. EA2003000064020011206; 2004
-
(2004)
-
-
-
50
-
-
33846637856
-
HCV core protein immunization with Montanide/CpG elicits strong Th1/Th2 and long-lived CTL responses
-
DOI 10.1016/j.bbrc.2006.12.232, PII S0006291X06028762
-
Roohvand F, Aghasadeghi MR, Sadat SM, et al. HCV core protein immunization with Montanide/CpG elicits strong Th1/Th2 and long-lived CTL responses. Biochem Biophys Res Commun 2007;354(3):641-9 This article reports the results of a comparative study for HCV core protein immunization in various adjuvant formulations. (Pubitemid 46186232)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.354
, Issue.3
, pp. 641-649
-
-
Roohvand, F.1
Aghasadeghi, M.-R.2
Sadat, S.M.3
Budkowska, A.4
Khabiri, A.-R.5
-
51
-
-
34547661663
-
Induction of potent cellular immune response in mice by hepatitis C virus NS3 protein with double-stranded RNA
-
DOI 10.1111/j.1365-2567.2007.02607.x
-
Jin B, Wang RY, Qiu Q, et al. Induction of potent cellular immune response in mice by hepatitis C virus NS3 protein with double-stranded RNA. Immunology 2007;122(1):15-27 (Pubitemid 47222591)
-
(2007)
Immunology
, vol.122
, Issue.1
, pp. 15-27
-
-
Jin, B.1
Wang, R.Y.2
Qiu, Q.3
Sugauchi, F.4
Grandinetti, T.5
Alter, H.J.6
Shih, J.W.-K.7
-
52
-
-
52349087506
-
Induction of multispecific Th-1 type immune response against HCV in mice by protein immunization using CpG and Montanide ISA 720 as adjuvants
-
This article reports the results of studies on combination of CpG and ISA 720 for various HCV proteins
-
Qiu Q, Wang RY, Jiao X, et al. Induction of multispecific Th-1 type immune response against HCV in mice by protein immunization using CpG and Montanide ISA 720 as adjuvants. Vaccine 2008;26(43):5527-34 This article reports the results of studies on combination of CpG and ISA 720 for various HCV proteins.
-
(2008)
Vaccine
, vol.26
, Issue.43
, pp. 5527-5534
-
-
Qiu, Q.1
Wang, R.Y.2
Jiao, X.3
-
53
-
-
77951602236
-
Immunostimulatory combinations of receptor agonists for vaccines and tumor immunotherapy
-
University of California. WO2007120368
-
University of California. Immunostimulatory combinations of receptor agonists for vaccines and tumor immunotherapy. WO2007120368; 2007
-
(2007)
-
-
-
54
-
-
77951592827
-
Immunostimulatory P-class oligonucleotide formulations for use in treating diseases and as vaccine adjuvants
-
Coley Pharmaceuticals GmbH. WO2007095316
-
Coley Pharmaceuticals GmbH. Immunostimulatory P-class oligonucleotide formulations for use in treating diseases and as vaccine adjuvants. WO2007095316; 2007
-
(2007)
-
-
-
55
-
-
2942685438
-
Priming with CpG-enriched plasmid and boosting with protein formulated with CpG oligodeoxynucleotides and Quil A induces strong cellular and humoral immune responses to hepatitis C virus NS3
-
DOI 10.1099/vir.0.79821-0
-
Yu H, Babiuk LA, van Drunen Littel-van den Hurk S, et al. Priming with CpG-enriched plasmid and boosting with protein formulated with CpG oligodeoxynucleotides and Quil A induces strong cellular and humoral immune responses to hepatitis C virus NS3. J Gen Virol 2004;85:1533-43 (Pubitemid 38807750)
-
(2004)
Journal of General Virology
, vol.85
, Issue.6
, pp. 1533-1543
-
-
Yu, H.1
Babiuk, L.A.2
Van Drunen L.-van Den, H.S.3
-
56
-
-
67649449054
-
CPG single-strand deoxynucleotides for use as adjuvant
-
Changchun Huapu Biotechnology. WO2006056142
-
Changchun Huapu Biotechnology. CPG single-strand deoxynucleotides for use as adjuvant. WO2006056142; 2006
-
(2006)
-
-
-
57
-
-
0037219273
-
Hepatitis C virus-like particles combined with novel adjuvant systems enhance virus-specific immune responses
-
DOI 10.1053/jhep.2003.50000
-
Qiao M, Murata K, Retal DA. Hepatitis C virus like particles combined with novel adjuvant systems enhance virus-specific immune responses. Hepatology 2003;37(1):52-9 (Pubitemid 36042144)
-
(2003)
Hepatology
, vol.37
, Issue.1
, pp. 52-59
-
-
Qiao, M.1
Murata, K.2
Davis, A.R.3
Jeong, S.-H.4
Liang, T.J.5
-
58
-
-
2942643933
-
Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates
-
M
-
HS, M, JeongQiaoNascimbeni M, et al. Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates. J Virol 2004;78(13):6995-7003
-
(2004)
J Virol
, vol.78
, Issue.13
, pp. 6995-7003
-
-
S, H.1
JeongQiaoNascimbeni, M.2
-
59
-
-
34347213785
-
Immunization with hepatitis C virus-like particles results in control of hepatitis C virus infection in chimpanzees
-
DOI 10.1073/pnas.0702162104
-
Elmovalid GA, Qiao M, Jeong SH, et al. Immunization with hepatitis C virus-like particles results in control of HCV infection in chimpanzees. Proc Natl Acad Sci USA 2007;104(20):8427-32 This article reports the results of studies on immunization ofchimpanzees with insect derived-VLPs formulated with modern adjuvants. (Pubitemid 47175504)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.20
, pp. 8427-8432
-
-
Elmowalid, G.A.1
Qiao, M.2
Jeong, S.-H.3
Borg, B.B.4
Baumert, T.F.5
Sapp, R.K.6
Hu, Z.7
Murthy, K.8
Liang, T.J.9
-
60
-
-
33746824144
-
Hepatitis C virus polyprotien vaccine formulations capable of inducing broad antibody and cellular immune responses
-
DOI 10.1099/vir.0.81849-0
-
Vajdy M, Selby M, Medina-Selby A, et al. Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses. J Gen Virol 2006;87:2253-62 (Pubitemid 44178102)
-
(2006)
Journal of General Virology
, vol.87
, Issue.8
, pp. 2253-2262
-
-
Vadly, M.1
Selby, M.2
Medina-Selby, A.3
Coit, D.4
Hall, J.5
Tandeske, L.6
Chien, D.7
Hu, C.8
Rosa, D.9
Singh, M.10
Kazzaz, J.11
Nguyen, S.12
Coates, S.13
Ng, P.14
Abrignani, S.15
Lin, Y.-L.16
Houghton, M.17
O'Hagan, D.T.18
-
61
-
-
84859641759
-
Thermosensitive pluronic Derivative Hydrogels with High Biodegradability and Biocompatibility for Tissue Regeneration and Preparation Method Thereof
-
US2010098762
-
Han DK, Park K, Kim J-J. Thermosensitive pluronic Derivative Hydrogels With High Biodegradability And Biocompatibility For Tissue Regeneration and Preparation Method Thereof. US2010098762; 2010
-
(2010)
-
-
Han, D.K.1
Park, K.2
Kim, J.-J.3
-
62
-
-
84859641972
-
Mycoplasma Hyopneumoniae Bacterin Vaccine
-
Wyeth Corp. US2010062018
-
Wyeth Corp. Mycoplasma Hyopneumoniae Bacterin Vaccine. US2010062018; 2010
-
(2010)
-
-
-
63
-
-
0025231388
-
Direct gene transfer into mouse muscle in vivo
-
The first report, indicating that direct injection of plasmid DNA in vivo results to gene expression
-
Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science 1990;247(4949 Pt 1):1465-8 The first report, indicating that direct injection of plasmid DNA in vivo results to gene expression.
-
(1990)
Science
, vol.247
, Issue.4949 PART 1
, pp. 1465-1468
-
-
Wolff, J.A.1
Malone, R.W.2
Williams, P.3
-
64
-
-
84859627189
-
Delivery of exogenous DNA sequences in a mammal
-
Vical, Inc. and Wisconsin Alumni Res Found. US5580859
-
Vical, Inc. and Wisconsin Alumni Res Found. Delivery of exogenous DNA sequences in a mammal. US5580859; 1996
-
(1996)
-
-
-
65
-
-
84859641983
-
Induction of a protective immune response in a mammal by injecting a DNA sequence
-
Vical, Inc. and Wisconsin Alumni Res Found. US5589466
-
Vical, Inc. and Wisconsin Alumni Res Found. Induction of a protective immune response in a mammal by injecting a DNA sequence. US5589466; 1996
-
(1996)
-
-
-
66
-
-
84859651848
-
Polynucleotide tuberculosis vaccine
-
Merck & Co, Inc. and Innogenetics NV. US5736524;
-
Merck & Co, Inc. and Innogenetics NV. Polynucleotide tuberculosis vaccine. US5736524; 1998
-
(1998)
-
-
-
67
-
-
84859627198
-
Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
-
Univ California. US5679647
-
Univ California. Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides. US5679647; 1997
-
(1997)
-
-
-
68
-
-
0035051928
-
West nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays
-
DOI 10.1128/JVI.75.9.4040-4047.2001
-
Davis BS, Chang GJ, Cropp B, et al. West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays. J Virol 2001;75(9):4040-7 This report provided the basis for the first approved DNA vaccine (protection of horses against West Nile Virus infection). (Pubitemid 32410116)
-
(2001)
Journal of Virology
, vol.75
, Issue.9
, pp. 4040-4047
-
-
Davis, B.S.1
Chang, G.-J.J.2
Cropp, B.3
Roehrig, J.T.4
Martin, D.A.5
Mitchell, C.J.6
Bowen, R.7
Bunning, M.L.8
-
69
-
-
84859651849
-
Enhanced delivery of naked DNA to skin by non-invasive in vivo Electroporation
-
Genetronics, Inc. US2006084938; This patent provided the basis for the delivery of DNA vaccines by non-invasive in vivo Electroporation
-
Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo Electroporation. US2006084938; 2006 This patent provided the basis for the delivery of DNA vaccines by non-invasive in vivo Electroporation.
-
(2006)
-
-
-
70
-
-
84859641971
-
Intracellular delivery of nucleic acids using pressure
-
Univ. Leland Stanford Junior. US5922687
-
Univ. Leland Stanford Junior. Intracellular delivery of nucleic acids using pressure. US5922687; 1999
-
(1999)
-
-
-
71
-
-
84859650770
-
Method and Apparatus for Introducing Biological Substances into Living Cells
-
Du Pont. US5204253
-
Du Pont. Method and Apparatus for Introducing Biological Substances Into Living Cells. US5204253; 1993
-
(1993)
-
-
-
72
-
-
33750796905
-
Modulation of the immune response induced by gene electrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates
-
Capone S, Zampaglione I, Vitelli A, et al. Modulation of the immune response induced by gene electrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates. J Immunol 2006;177(10):7462-71 This article provided the clear evidence for enhancement of immune responses by electroporation mediated delivery of antigens. (Pubitemid 44715117)
-
(2006)
Journal of Immunology
, vol.177
, Issue.10
, pp. 7462-7471
-
-
Capone, S.1
Zampaglione, I.2
Vitelli, A.3
Pezzanera, M.4
Kierstead, L.5
Burns, J.6
Ruggeri, L.7
Arcuri, M.8
Cappelletti, M.9
Meola, A.10
Ercole, B.B.11
Tafi, R.12
Santini, C.13
Luzzago, A.14
Fu, T.-M.15
Celloca, S.16
Ciliberto, G.17
Cortese, R.18
Nicosia, A.19
Fattori, E.20
Folgori, A.21
more..
-
73
-
-
84859648699
-
Methods and Compositions for in Vivo Gene Therapy
-
Univ. California. WO9324640
-
Univ. California. Methods and Compositions for In Vivo Gene Therapy. WO9324640; 1993
-
(1993)
-
-
-
74
-
-
84859641976
-
Liposomal transfection of nucleic acids into animal cells
-
Univ. Yale. US5279833
-
Univ. Yale. Liposomal transfection of nucleic acids into animal cells. US5279833; 1994
-
(1994)
-
-
-
75
-
-
84859641974
-
Immunogenic Liposome compositions
-
Molecular Express, Inc. EA004797
-
Molecular Express, Inc. Immunogenic Liposome compositions. EA004797; 2004
-
(2004)
-
-
-
76
-
-
67649445985
-
Adjuvanted genetic vaccines
-
Powderject Vaccines, Inc. WO2001032208
-
Powderject Vaccines, Inc. Adjuvanted genetic vaccines. WO2001032208; 2001
-
(2001)
-
-
-
77
-
-
81855191789
-
Surface Targeted Expression of A Modified Hepatitis C Virus Envelope Protein
-
US Health. WO9966033
-
US Health. Surface Targeted Expression of A Modified Hepatitis C Virus Envelope Protein. WO9966033; 1999
-
(1999)
-
-
-
78
-
-
0033537880
-
DNA immunization of mice and macaques with plasmids encoding hepatitis C virus envelope E2 protein expressed intracellularly and on the cell surface
-
DOI 10.1016/S0264-410X(98)00448-4, PII S0264410X98004484
-
Forns X, Emerson SU, Tobin GJ, et al. DNA immunization of mice and macaques with plasmids encoding hepatitis C virus envelope E2 protein expressed intracellular and on the cell surface. Vaccine 1999;17(15-16):1992-2002 (Pubitemid 29172370)
-
(1999)
Vaccine
, vol.17
, Issue.15-16
, pp. 1992-2002
-
-
Forns, X.1
Emerson, S.U.2
Tobin, G.J.3
Mushahwar, I.K.4
Purcell, R.H.5
Bukh, J.6
-
79
-
-
84859638868
-
The DNA vaccine of an anti-infection of hepatitis C virus
-
Univ Wuhan. CN1943789
-
Univ Wuhan. The DNA vaccine of an anti-infection of hepatitis C virus. CN1943789; 2007
-
(2007)
-
-
-
80
-
-
0029156764
-
Immune responses to plasmid DNA encoding the hepatitis C virus core protein
-
One of the first articles, reporting HCV DNA vaccine immunization
-
Lagging LM, Meyer K, Hoft D, et al. Immune responses to plasmid DNA encoding the hepatitis C virus core protein. J Virol 1995;69(9):5859-63 One of the first articles, reporting HCV DNA vaccine immunization.
-
(1995)
J Virol
, vol.69
, Issue.9
, pp. 5859-5863
-
-
Lagging, L.M.1
Meyer, K.2
Hoft, D.3
-
81
-
-
62949194424
-
Effect of immunological adjuvants: GM-CSF (granulocyte-monocyte colony stimulating factor) and IL-23 (interleukin-23) on immune responses generated against hepatitis C virus core DNA vaccine
-
Hartoonian C, Ebtekar M, Soleimanjahi H, et al. Effect of immunological adjuvants: GM-CSF (granulocyte-monocyte colony stimulating factor) and IL-23 (interleukin-23) on immune responses generated against hepatitis C virus core DNA vaccine. Cytokine 2009;46(1):43-50
-
(2009)
Cytokine
, vol.46
, Issue.1
, pp. 43-50
-
-
Hartoonian, C.1
Ebtekar, M.2
Soleimanjahi, H.3
-
82
-
-
84859641975
-
Vaccine Composition Potentiated with DNA and Antigen Combination
-
Cigb. RU2294212
-
Cigb. Vaccine Composition Potentiated with DNA and Antigen Combination. RU2294212; 2007
-
(2007)
-
-
-
83
-
-
60349132278
-
Immunogenicity of CIGB-230, a therapeutic DNA vaccine preparation, in HCV-chronically infected individuals in a phase I clinical trial
-
Alvarez-Lajonchere L, Shoukry NH, Gra B, et al. Immunogenicity of CIGB-230, a therapeutic DNA vaccine preparation, in HCV-chronically infected individuals in a phase I clinical trial. J Viral Hepat 2009;16(3):156-67
-
(2009)
J Viral Hepat
, vol.16
, Issue.3
, pp. 156-167
-
-
Alvarez-Lajonchere, L.1
Shoukry, N.H.2
Gra, B.3
-
84
-
-
75449095840
-
Immunization with a DNA vaccine candidate in chronic hepatitis C patients is safe, well tolerated and does not impair immune response induction after anti-hepatitis B vaccination
-
Castellanos M, Cinza Z, Dorta Z, et al. Immunization with a DNA vaccine candidate in chronic hepatitis C patients is safe, well tolerated and does not impair immune response induction after anti-hepatitis B vaccination. J Gene Med 2010;12(1):107-16
-
(2010)
J Gene Med
, vol.12
, Issue.1
, pp. 107-116
-
-
Castellanos, M.1
Cinza, Z.2
Dorta, Z.3
-
85
-
-
84859632726
-
Hepatitis C Virus Codon Optimized Non-Structural NS3/4A Fusion Gene
-
Tripep AB. US2010104592
-
Tripep AB. Hepatitis C Virus Codon Optimized Non-Structural NS3/4A Fusion Gene. US2010104592; 2010
-
(2010)
-
-
-
86
-
-
28844440938
-
In vivo clearance of hepatitis C virus nonstructural 3/4A-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes
-
DOI 10.1086/498218
-
Ahlen G, Nystrom J, Pult I, et al. In vivo clearance of hepatitis C virus nonstructural 3/4A-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes. J Infect Dis 2005;192:2112-16 (Pubitemid 41779209)
-
(2005)
Journal of Infectious Diseases
, vol.192
, Issue.12
, pp. 2112-2116
-
-
Ahlen, G.1
Nystrom, J.2
Pult, I.3
Frelin, L.4
Hultgren, C.5
Sallberg, M.6
-
87
-
-
43849104724
-
In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural 3/4A DNA by increased local DNA uptake, protein expression inflammation, and infiltration of CD3+ T cells
-
Ahlen G, Soderholm J, Tjelle T, et al. In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural 3/4A DNA by increased local DNA uptake, protein expression inflammation, and infiltration of CD3+ T cells. J Immunol 2007;179:4741-53
-
(2007)
J Immunol
, vol.179
, pp. 4741-4753
-
-
Ahlen, G.1
Soderholm, J.2
Tjelle, T.3
-
88
-
-
84859651836
-
-
ClinicalTrials.gov Identifier: NCT00563173. Available from. Accessed on January 2012 This web site provides the results of the phase I studies on ChronVac-C vaccine
-
ClinicalTrials.gov Identifier: NCT00563173. Available from. http://clinicaltrials.gov/show/NCT00563173 [Accessed on January 2012] This web site provides the results of the phase I studies on ChronVac-C vaccine.
-
-
-
-
89
-
-
0025945836
-
In vivo efficacy of virus-derived peptides and virus-specific cytotoxic T lymphocytes
-
This review summarizes the different aspects of epitopic/peptide (CTLs) immunization
-
Kast WM, Melief CJ. In vivo efficacy of virus-derived peptides and virus-specific cytotoxic T lymphocytes. Immunol Lett 1991;30:229-32 This review summarizes the different aspects of epitopic/peptide (CTLs) immunization.
-
(1991)
Immunol Lett
, vol.30
, pp. 229-232
-
-
Kast, W.M.1
Melief, C.J.2
-
90
-
-
0036196269
-
Challenges in the development of effective peptide vaccines for cancer
-
Buteau C, Markovic SN, Celis E. Challenges in the development of effective peptide vaccines for cancer. Mayo Clin Proc 2002;77:339--349.
-
(2002)
Mayo Clin Proc
, vol.77
, pp. 339-349
-
-
Buteau, C.1
Markovic, S.N.2
Celis, E.3
-
91
-
-
82255174297
-
Universal peptide vaccines - Optimal peptide vaccine designbased on viral sequence conservation
-
Toussaint NC, Maman Y, Kohlbacher O, et al. Universal peptide vaccines - optimal peptide vaccine designbased on viral sequence conservation. Vaccine 2011;29(47):8745-53
-
(2011)
Vaccine
, vol.29
, Issue.47
, pp. 8745-8753
-
-
Toussaint, N.C.1
Maman, Y.2
Kohlbacher, O.3
-
92
-
-
0033388725
-
SYFPEITHI: Database for MHC ligands and peptide motifs
-
Rammensee H, Bachmann J, Emmerich NP, et al. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 1999;50(3-4):213-19 (Pubitemid 30099526)
-
(1999)
Immunogenetics
, vol.50
, Issue.3-4
, pp. 213-219
-
-
Rammensee, H.-G.1
Bachmann, J.2
Emmerich, N.P.N.3
Bachor, O.A.4
Stevanovic, S.5
-
93
-
-
77951614789
-
System and method for automated selection of T-cell epitopes
-
Merck & Co, Inc. WO2006124408;
-
Merck & Co, Inc. System and method for automated selection of T-cell epitopes. WO2006124408; 2006
-
(2006)
-
-
-
94
-
-
77951531438
-
HLA binding motifs and immunogenic peptides and their uses for vaccines against desired antigens
-
Epimmune, Inc. US20070055049; This patent introduces the software and databases for identification of CTL and epitopic peptides
-
Epimmune, Inc. HLA binding motifs and immunogenic peptides and their uses for vaccines against desired antigens. US20070055049; 2007 This patent introduces the software and databases for identification of CTL and epitopic peptides.
-
(2007)
-
-
-
95
-
-
84859638496
-
Targeted identification of immunogenic peptides
-
Henry M. Jackson Foundation for the Advancement of Military Medicine Institute. WO2009112792
-
Henry M. Jackson Foundation for the Advancement of Military Medicine Institute. Targeted identification of immunogenic peptides. WO2009112792; 2009
-
(2009)
-
-
-
97
-
-
84859627192
-
Method, Computing Routine, Device for Predicting Properties of MHC/PEPTIDE Complexes, and Data and Peptides Produced Therefrom
-
Algonomics NV. WO03105058
-
Algonomics NV. Method, Computing Routine, Device for Predicting Properties of MHC/PEPTIDE Complexes, and Data and Peptides Produced Therefrom. WO03105058; 2003
-
(2003)
-
-
-
98
-
-
84859651838
-
Identification of HLA-DR Restricted HCV Epitopes
-
Imp College Innovations Ltd. WO0234770
-
Imp College Innovations Ltd. Identification of HLA-DR Restricted HCV Epitopes. WO0234770; 2002
-
(2002)
-
-
-
99
-
-
81855191797
-
Inducing cellular immune responses to Hepatitis C virus using peptide and nucleic acid compositions
-
Epimmune, Inc. WO0121189
-
Epimmune, Inc. Inducing cellular immune responses to Hepatitis C virus using peptide and nucleic acid compositions. WO0121189; 2001
-
(2001)
-
-
-
100
-
-
81855191795
-
Peptides for Inducing Cytotoxic T Lymphocyte Responses to Hepatitis C Virus
-
Scripps Research Inst. WO9525122
-
Scripps Research Inst. Peptides for Inducing Cytotoxic T Lymphocyte Responses to Hepatitis C Virus. WO9525122; 1995
-
(1995)
-
-
-
101
-
-
84859632395
-
Immunodominant Human T-Cell Epitopes of Hepatitis C Virus
-
Innogenetics NV. WO9512677; 1995 and JP2004194668
-
Innogenetics NV. Immunodominant Human T-Cell Epitopes of Hepatitis C Virus. WO9512677; 1995 and JP2004194668; 2004
-
(2004)
-
-
-
102
-
-
84859651837
-
HLA-A2.1 and HLA Binding Peptides and Their Uses
-
Cytel Corp. WO9420127; 1994 and WO9403205
-
Cytel Corp. HLA-A2.1 and HLA Binding Peptides and Their Uses. WO9420127; 1994 and WO9403205; 1994
-
(1994)
-
-
-
103
-
-
84859644788
-
Inducing Cellular Immune Responses to Hepatitis B Virus Using Peptide and Nucleic Acid Compositions
-
Pharmexa, Inc. US2010068228
-
Pharmexa, Inc. Inducing Cellular Immune Responses to Hepatitis B Virus Using Peptide and Nucleic Acid Compositions. US2010068228; 2010
-
(2010)
-
-
-
104
-
-
67649416153
-
Compositions and methods for eliciting CTL immunity
-
Epimmune, Inc. US6419931
-
Epimmune, Inc. Compositions and methods for eliciting CTL immunity. US6419931; 2002
-
(2002)
-
-
-
105
-
-
84859641980
-
Alteration of immune response using pan DR-binding peptides
-
Cytel Corp. US5736142
-
Cytel Corp. Alteration of immune response using pan DR-binding peptides. US5736142; 1998
-
(1998)
-
-
-
106
-
-
84859644787
-
Epitopes of Virus Hepatitis C Specifically CD4+ T Lymphocytes
-
Immuosystems Gmbh. WO0226785
-
Immuosystems Gmbh. Epitopes of Virus Hepatitis C Specifically CD4+ T Lymphocytes. WO0226785; 2002
-
(2002)
-
-
-
107
-
-
81855218453
-
Peptides for inducing a CTL and/or HTL responses to Hepatitis C virus
-
Innogenetics N.V. and IDM Pharma, Inc. WO2005118626A2
-
Innogenetics N.V. and IDM Pharma, Inc. Peptides for inducing a CTL and/or HTL responses to Hepatitis C virus. WO2005118626A2; 2005
-
(2005)
-
-
-
108
-
-
81855191793
-
Hepatitis C Virus Core Peptide for Stimulation of Cytotoxic T Lymphocytes and Diagnosis of HCV Exposure
-
US Health. WO9527733
-
US Health. Hepatitis C Virus Core Peptide for Stimulation of Cytotoxic T Lymphocytes and Diagnosis of HCV Exposure. WO9527733; 1995
-
(1995)
-
-
-
109
-
-
35348990912
-
Induction of the TH1/TC1 type immunity in chronic hepatitis C non-responder patients with the therapeutic peptide vaccine IC41
-
Wedemeyer H, Berg T, Manns MP, et al. Induction of the TH1/TC1 type immunity in chronic hepatitis C non-responder patients with the therapeutic peptide vaccine IC41. J Hepatol 2005;42(Suppl 2):A19
-
(2005)
J Hepatol
, vol.42
, Issue.SUPPL. 2
-
-
Wedemeyer, H.1
Berg, T.2
Manns, M.P.3
-
110
-
-
81855218454
-
HCV Vaccines for Chronic HCV Patients
-
US2010322972
-
Frisch J, Tauber E, Buerger V, et al. HCV Vaccines for Chronic HCV Patients. US2010322972; 2010
-
(2010)
-
-
Frisch, J.1
Tauber, E.2
Buerger, V.3
-
111
-
-
33646144429
-
Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: A randomized, placebo controlled trial for dose optimization in 128 healthy subjects
-
This article provides the results of the phase I studies on IC41 vaccine
-
Firbas C, Jilma B, Tauber E, et al. Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects. Vaccine 2006;24:4343-53 This article provides the results of the phase I studies on IC41 vaccine.
-
(2006)
Vaccine
, vol.24
, pp. 4343-4353
-
-
Firbas, C.1
Jilma, B.2
Tauber, E.3
-
112
-
-
42949111104
-
Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41
-
Klade CS, Wedemeyer H, Berg T, et al. Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41. Gastroent 2008;134:1385-95
-
(2008)
Gastroent
, vol.134
, pp. 1385-1395
-
-
Klade, C.S.1
Wedemeyer, H.2
Berg, T.3
-
114
-
-
67650734950
-
Therapeutic vaccine IC41 as late add-on to standard treatment in patients with chronic hepatitis C
-
Wedemeyer H, Schuller E, Schlaphoff V, et al. Therapeutic vaccine IC41 as late add-on to standard treatment in patients with chronic hepatitis C. Vaccine 2009;27(37):5142-515
-
(2009)
Vaccine
, vol.27
, Issue.37
, pp. 5142-5515
-
-
Wedemeyer, H.1
Schuller, E.2
Schlaphoff, V.3
-
115
-
-
77549085401
-
Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine
-
This article provides the results of the phase II studies on IC41 vaccine
-
Firbas C, Boehm T, Buerger V, et al. Immunogenicity and safety of different injection routes and schedules of IC41, a Hepatitis C virus (HCV) peptide vaccine. Vaccine 2010; 28(12):2397-407 This article provides the results of the phase II studies on IC41 vaccine.
-
(2010)
Vaccine
, vol.28
, Issue.12
, pp. 2397-2407
-
-
Firbas, C.1
Boehm, T.2
Buerger, V.3
-
116
-
-
34748815771
-
Phase I clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus (HCV) 1b who failed to respond to interferon-based therapy
-
DOI 10.1016/j.vaccine.2007.08.005, PII S0264410X0700919X
-
Yutani S, Yamada A, Yoshida K, et al. Phase I clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus (HCV) 1b who failed to respond to interferon-based therapy. Vaccine 2007;25(42):7429-35 (Pubitemid 47484009)
-
(2007)
Vaccine
, vol.25
, Issue.42
, pp. 7429-7435
-
-
Yutani, S.1
Yamada, A.2
Yoshida, K.3
Takao, Y.4
Tamura, M.5
Komatsu, N.6
Ide, T.7
Tanaka, M.8
Sata, M.9
Itoh, K.10
-
117
-
-
81855218450
-
Peptide Derived from Hepatitis C Virus
-
Green Peptide Co. Ltd. US2010292138
-
Green Peptide Co. Ltd. Peptide Derived from Hepatitis C Virus. US2010292138; 2010
-
(2010)
-
-
-
118
-
-
70349596123
-
Phase I clinical study of a peptide vaccination for hepatitis C virus-infected patients with different human leukocyte antigen-class I-A alleles
-
Yutani S, Komatsu N, Shichijo S, et al. Phase I clinical study of a peptide vaccination for hepatitis C virus-infected patients with different human leukocyte antigen-class I-A alleles. Cancer Sci 2009;100(10):1935-42
-
(2009)
Cancer Sci
, vol.100
, Issue.10
, pp. 1935-1942
-
-
Yutani, S.1
Komatsu, N.2
Shichijo, S.3
-
119
-
-
46349100543
-
Cross-genotype-reactivity of the immunodominant HCV CD8 T-cell epitope NS3-1073
-
Fytili P, Dalekos GN, Schlaphoff V, et al. Cross-genotype-reactivity of the immunodominant HCV CD8 T-cell epitope NS3-1073. Vaccine 2008;26:3818-26
-
(2008)
Vaccine
, vol.26
, pp. 3818-3826
-
-
Fytili, P.1
Dalekos, G.N.2
Schlaphoff, V.3
-
120
-
-
84859633533
-
Method for Isolating Hepatitis C Virus Peptide
-
Intercell AG. US2009081246; 2009 and JP2010265262
-
Intercell AG. Method for Isolating Hepatitis C Virus Peptide. US2009081246; 2009 and JP2010265262; 2010
-
(2010)
-
-
-
121
-
-
77957756030
-
A Phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals
-
Gowans EJ, Roberts S, Jones K, et al. A Phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals. J Hepatol 2010;53(4):599-607
-
(2010)
J Hepatol
, vol.53
, Issue.4
, pp. 599-607
-
-
Gowans, E.J.1
Roberts, S.2
Jones, K.3
-
122
-
-
35348998498
-
Influenza virosomes as a combined vaccine carrier and adjuvant system for prophylactic and therapeutic immunizations
-
DOI 10.1586/14760584.6.5.711
-
Moser C, Amacker M, Kammer AR, et al. Influenza virosomes as a combined vaccine carrier and adjuvant system for prophylactic and therapeutic immunizations. Expert Rev Vaccin 2007;6(5):711-21 (Pubitemid 47610491)
-
(2007)
Expert Review of Vaccines
, vol.6
, Issue.5
, pp. 711-721
-
-
Moser, C.1
Amacker, M.2
Kammer, A.R.3
Rasi, S.4
Westerfeld, N.5
Zurbriggen, R.6
-
123
-
-
84859628113
-
Virosomes comprising hemagglutinin derived from an influenza virus produced in a cell line, compositions, methods of manufacturing, use thereof
-
Pevion Biotech AG. EP2014279
-
Pevion Biotech AG. Virosomes comprising hemagglutinin derived from an influenza virus produced in a cell line, compositions, methods of manufacturing, use thereof. EP2014279; 2009
-
(2009)
-
-
-
124
-
-
84859651839
-
-
ClinicalTrials.gov Identifier: NCT00445419. Available from: Accessed on January 2012 This web site provides the results of the phase I studies on PEVION BIOTECH AG. HCV virosome vaccine
-
ClinicalTrials.gov Identifier: NCT00445419. Available from: http://clinicaltrials.gov/show/NCT00445419 [Accessed on January 2012] This web site provides the results of the phase I studies on PEVION BIOTECH AG. HCV virosome vaccine.
-
-
-
-
125
-
-
67849111911
-
Polytope DNA vaccine development against hepatitis C virus:a streamlined approach from in silico design to in vitro and primary in vivo analyses in BALB/c mice
-
This article provides a practical and step by step approach for design, construction and evaluation of the immune responses to HCV polytope vaccines
-
Memarnejadian A, Roohvand F, Arashkia A, et al. Polytope DNA vaccine development against hepatitis C virus:a streamlined approach from in silico design to in vitro and primary in vivo analyses in BALB/c mice. Protein Pept Lett 2009; 16(7):842-50 This article provides a practical and step by step approach for design, construction and evaluation of the immune responses to HCV polytope vaccines.
-
(2009)
Protein Pept Lett
, vol.16
, Issue.7
, pp. 842-850
-
-
Memarnejadian, A.1
Roohvand, F.2
Arashkia, A.3
-
126
-
-
77149141084
-
Construction of HCV-polytope vaccine candidates harbouring immune-enhancer sequences and primary evaluation of their immunogenicity in BALB/c mice
-
This article reports the enhancing effect of PADRE and ERss on immune responses to HCV polytope vaccine
-
Arashkia A, Roohvand F, Memarnejadian A, et al. Construction of HCV-polytope vaccine candidates harbouring immune-enhancer sequences and primary evaluation of their immunogenicity in BALB/c mice. Virus Genes 2010;40(1):44-52 This article reports the enhancing effect of PADRE and ERss on immune responses to HCV polytope vaccine.
-
(2010)
Virus Genes
, vol.40
, Issue.1
, pp. 44-52
-
-
Arashkia, A.1
Roohvand, F.2
Memarnejadian, A.3
-
127
-
-
79958045785
-
Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challenges
-
This article reports the importance of subdominant HCV epitopes for construction of HCV polytope vaccines
-
Im EJ, Hong JP, Roshorm Y, et al. Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challenges. PLoS Pathog 2011;7(5):e1002041 This article reports the importance of subdominant HCV epitopes for construction of HCV polytope vaccines.
-
(2011)
PLoS Pathog
, vol.7
, Issue.5
-
-
Im, E.J.1
Hong, J.P.2
Roshorm, Y.3
-
128
-
-
79952761607
-
Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection
-
Zhang Y, Ma CJ, Ni L, et al. Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection. J Immunol 2011;186(5):3093-103
-
(2011)
J Immunol
, vol.186
, Issue.5
, pp. 3093-3103
-
-
Zhang, Y.1
Ma, C.J.2
Ni, L.3
-
129
-
-
77649184813
-
Fusion of HBsAg and prime/boosting augment Th1 and CTL responses to HCV polytope DNA vaccine
-
This article reports the importance of both prime/boosting and HBsAg fusion (particulate formation) in enhancing the immune responses to HCV polytopes
-
Memarnejadian A, Roohvand F. Fusion of HBsAg and prime/boosting augment Th1 and CTL responses to HCV polytope DNA vaccine. Cell Immunol 2010;261(2):93-8 This article reports the importance of both prime/boosting and HBsAg fusion (particulate formation) in enhancing the immune responses to HCV polytopes.
-
(2010)
Cell Immunol
, vol.261
, Issue.2
, pp. 93-98
-
-
Memarnejadian, A.1
Roohvand, F.2
-
130
-
-
43049144208
-
A vector-based minigene vaccine approach results in strong induction of T-cell responses specific of hepatitis C virus
-
Martin P, Simon B, Lone YC, et al. A vector-based minigene vaccine approach results in strong induction of T-cell responses specific of hepatitis C virus. Vaccine 2008; 26(20):2471-81
-
(2008)
Vaccine
, vol.26
, Issue.20
, pp. 2471-2481
-
-
Martin, P.1
Simon, B.2
Lone, Y.C.3
-
131
-
-
84859651841
-
Multiple Epitope Fusion Protein
-
Chiron Corp. WO9744469
-
Chiron Corp. Multiple Epitope Fusion Protein. WO9744469; 1997
-
(1997)
-
-
-
132
-
-
81855199090
-
Hepatitis C virus multi copy epitope fusion antigens
-
Chiron Corp. US6428792
-
Chiron Corp. Hepatitis C virus multi copy epitope fusion antigens. US6428792; 2002
-
(2002)
-
-
-
133
-
-
84859639701
-
Multi-epitope gene of hepatitis C and its nucleic acid vaccine
-
First Hospital of Jilin Univer. CN1690207
-
First Hospital of Jilin Univer. Multi-epitope gene of hepatitis C and its nucleic acid vaccine. CN1690207; 2005
-
(2005)
-
-
-
134
-
-
84859644789
-
-
Nationwide Childrens Hospital. US2010260800
-
Nationwide Childrens Hospital. AVV Vectors and Methods. US2010260800; 2010
-
(2010)
AVV Vectors and Methods
-
-
-
135
-
-
84859651842
-
-
Univ Massachusetts. WO2010138263
-
Univ Massachusetts. Novel AAV 'S and Uses Thereof. WO2010138263; 2010
-
(2010)
Novel AAV 'S and Uses Thereof
-
-
-
136
-
-
84859651844
-
Recombinant AAV Based Vaccine Methods
-
Targeted Genetics Corp. and Childrens Hospital, Inc. WO2006073496
-
Targeted Genetics Corp. and Childrens Hospital, Inc. Recombinant AAV Based Vaccine Methods. WO2006073496; 2006
-
(2006)
-
-
-
137
-
-
0037122719
-
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
-
DOI 10.1038/415331a
-
Shiver JW, Fu TM, Chen L, et al. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 2002;415:331-5 (Pubitemid 34087555)
-
(2002)
Nature
, vol.415
, Issue.6869
, pp. 331-335
-
-
Shiver, J.W.1
Fu, T.-M.2
Chen, L.3
Casimiro, D.R.4
Davies, M.-E.5
Evans, R.K.6
Zhang, Z.-Q.7
Simon, A.J.8
Trigona, W.L.9
Dubey, S.A.10
Huang, L.11
Harris, V.A.12
Long, R.S.13
Liang, X.14
Handt, L.15
Schleif, W.A.16
Zhu, L.17
Freed, D.C.18
Persaud, N.V.19
Guan, L.20
Punt, K.S.21
Tang, A.22
Chen, M.23
Wilson, K.A.24
Collins, K.B.25
Heidecker, G.J.26
Fernandez, V.R.27
Perry, H.C.28
Joyce, J.G.29
Grimm, K.M.30
Cook, J.C.31
Keller, P.M.32
Kresock, D.S.33
Mach, H.34
Troutman, R.D.35
Isopi, L.A.36
Williams, D.M.37
Xu, Z.38
Bohannon, K.E.39
Volkin, D.B.40
Montefiori, D.C.41
Miura, A.42
Krivulka, G.R.43
Lifton, M.A.44
Kuroda, M.J.45
Schmitz, J.E.46
Letvin, N.L.47
Caulfield, M.J.48
Bett, A.J.49
Youil, R.50
Kaslow, D.C.51
Emini, E.A.52
more..
-
138
-
-
0038664390
-
Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
-
DOI 10.1128/JVI.77.11.6305-6313.2003
-
Casimiro DR, Chen L, Fu TM, et al. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol 2003;77:6305-13 (Pubitemid 36588400)
-
(2003)
Journal of Virology
, vol.77
, Issue.11
, pp. 6305-6313
-
-
Casimiro, D.R.1
Chen, L.2
Fu, T.-M.3
Evans, R.K.4
Caulfield, M.J.5
Davies, M.-E.6
Tang, A.7
Chen, M.8
Huang, L.9
Harris, V.10
Freed, D.C.11
Wilson, K.A.12
Dubey, S.13
Zhu, D.-M.14
Nawrocki, D.15
Mach, H.16
Troutman, R.17
Isopi, L.18
Williams, D.19
Hurni, W.20
Xu, Z.21
Smith, J.G.22
Wang, S.23
Liu, X.24
Guan, L.25
Long, R.26
Trigona, W.27
Heidecker, G.J.28
Perry, H.C.29
Persaud, N.30
Toner, T.J.31
Su, Q.32
Liang, X.33
Youil, R.34
Chastain, M.35
Bett, A.J.36
Volkin, D.B.37
Emini, E.A.38
Shiver, J.W.39
more..
-
139
-
-
0019943334
-
Neutralizing antibodies against 33 human adenoviruses in normal children in Rome
-
D'Ambrosio E, Del Grosso N, Chicca A, et al. Neutralizing antibodies against 33 human adenoviruses in normal children in Rome. J Hyg 1982;89:155-61 (Pubitemid 12051350)
-
(1982)
Journal of Hygiene
, vol.89
, Issue.1
, pp. 155-161
-
-
D'Ambrosio, E.1
Del, G.N.2
Chicca, A.3
Midulla, M.4
-
140
-
-
77951598373
-
Chimpanzee adenovirus vaccine carriers
-
Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA, Italy. WO2005071093
-
Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA, Italy. Chimpanzee adenovirus vaccine carriers. WO2005071093; 2005
-
(2005)
-
-
-
141
-
-
77951553750
-
Sequences for simian adenoviruses of subfamily C, SAdV-40, SAdV-31 or SAdV-34, and uses thereof for gene delivery, vaccination and recombinant production
-
The Trustees of the University of Pennsylvania, USA. WO2009105084
-
The Trustees of the University of Pennsylvania, USA. Sequences for simian adenoviruses of subfamily C, SAdV-40, SAdV-31 or SAdV-34, and uses thereof for gene delivery, vaccination and recombinant production. WO2009105084; 2009
-
(2009)
-
-
-
142
-
-
84859635643
-
Hepatitis C virus Vaccine
-
US2010129901
-
Kaslow David C, Bett Andrew J. Hepatitis C virus Vaccine. US2010129901; 2010
-
(2010)
-
-
Kaslow, D.C.1
Bett, A.J.2
-
143
-
-
32444449395
-
A novel adenovirus type 6 (Ad6)-based hepatitis C virus vector that Overcomes preexisting anti-Ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques
-
This article introduces the employment of Ad6 vector for immunization aims
-
Capone S, Meola A, Ercole BB, et al. A novel adenovirus type 6 (Ad6)-based hepatitis C virus vector that Overcomes preexisting anti-Ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques. J Virol 2006;80(4):1688-99 This article introduces the employment of Ad6 vector for immunization aims.
-
(2006)
J Virol
, vol.80
, Issue.4
, pp. 1688-1699
-
-
Capone, S.1
Meola, A.2
Ercole, B.B.3
-
144
-
-
33745759317
-
Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes
-
Fattori E, Zampaglione I, Arcuri M, et al. Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes. Gene Ther 2006;13:1088-96
-
(2006)
Gene Ther
, vol.13
, pp. 1088-1096
-
-
Fattori, E.1
Zampaglione, I.2
Arcuri, M.3
-
145
-
-
81855199091
-
Simian Adenovirus Nucleic Acid- And Amino Acid-Sequences, Vectors Containing same, and Uses Thereof
-
Okairos. AG Switzerland. WO2010086189
-
Okairos. AG Switzerland. Simian Adenovirus Nucleic Acid- and Amino Acid-Sequences, Vectors Containing same, and Uses Thereof. WO2010086189; 2010
-
(2010)
-
-
-
146
-
-
32244435842
-
A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
-
DOI 10.1038/nm1353, PII NM1353
-
Folgori A, Capone S, Ruggeri L, et al. A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat Med 2006;12:190-7 (Pubitemid 43214745)
-
(2006)
Nature Medicine
, vol.12
, Issue.2
, pp. 190-197
-
-
Folgori, A.1
Capone, S.2
Ruggeri, L.3
Meola, A.4
Sporeno, E.5
Ercole, B.B.6
Pezzanera, M.7
Tafi, R.8
Arcuri, M.9
Fattori, E.10
Lahm, A.11
Luzzago, A.12
Vitelli, A.13
Colloca, S.14
Cortese, R.15
Nicosia, A.16
-
147
-
-
81855163726
-
Hepatitis C Virus Nucleic Acid Vaccine
-
US2009035277
-
Colloca S, Folgori A, Lahm A. Hepatitis C Virus Nucleic Acid Vaccine. US2009035277; 2009
-
(2009)
-
-
Colloca, S.1
Folgori, A.2
Lahm, A.3
-
148
-
-
84859641981
-
-
ClinicalTrials.gov Identifier: NCT01070407. Available from: Accessed on January 2012 This web site provides the results of the phase I studies on Okairos HCV virosome vaccine
-
ClinicalTrials.gov Identifier: NCT01070407. Available from: http://clinicaltrials.gov/ct2/show/NCT01070407 [Accessed on January 2012] This web site provides the results of the phase I studies on Okairos HCV virosome vaccine.
-
-
-
-
149
-
-
79951833033
-
Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain
-
Mikkelsen M, Holst PJ, Bukh J, et al. Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain. J Immunol 2011;186(4):2355-64
-
(2011)
J Immunol
, vol.186
, Issue.4
, pp. 2355-2364
-
-
Mikkelsen, M.1
Holst, P.J.2
Bukh, J.3
-
150
-
-
81855163736
-
Anti-HCV Vaccine and Preparation Methods and Uses Thereof
-
Peking University Peoples Hospital. US2010310605
-
Peking University Peoples Hospital. Anti-HCV Vaccine and Preparation Methods and Uses Thereof. US2010310605; 2010
-
(2010)
-
-
-
151
-
-
33646485781
-
Induction of primary human T cell responses against hepatitis C virus-derived antigens NS3 or core by autologous dendritic cells expressing hepatitis C virus antigens: Potential for vaccine and immunotherapy
-
Li W, Krishnadas DK, Li J, et al. Induction of primary human T cell responses against hepatitis C virus-derived antigens NS3 or core by autologous dendritic cells expressing hepatitis C virus antigens: potential for vaccine and immunotherapy. J Immunol 2006;176(10):6065-75
-
(2006)
J Immunol
, vol.176
, Issue.10
, pp. 6065-6075
-
-
Li, W.1
Krishnadas, D.K.2
Li, J.3
-
152
-
-
0018246525
-
The smallpox vaccination strain MVA: Marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism
-
Mayr A, Stickl H, Muller HK, et al. The smallpox vaccination strain MVA: marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism. Zentralbl Bakteriol 1978;167(5--6):375-90
-
(1978)
Zentralbl Bakteriol
, vol.167
, Issue.5-6
, pp. 375-390
-
-
Mayr, A.1
Stickl, H.2
Muller, H.K.3
-
153
-
-
0026442276
-
Non-replicating vaccinia vector efficiently expresses recombinant genes
-
Sutter G, Moss B. Non-replicating vaccinia vector efficiently expresses recombinant genes. Proc Natl Acad Sci USA 1992;89(22):10847-51
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.22
, pp. 10847-10851
-
-
Sutter, G.1
Moss, B.2
-
154
-
-
84859649554
-
Genetically Stable Recombinant Modified Vaccinia Ankara (RMVA)Vaccines and Methods of Preparation Thereof
-
US2010316667
-
Diamond Don and Wang Zhongde. Genetically Stable Recombinant Modified Vaccinia Ankara (RMVA)Vaccines and Methods of Preparation Thereof. US2010316667; 2010
-
(2010)
-
-
Don, D.1
Zhongde, W.2
-
155
-
-
84859644793
-
Recombinant Modified Ankara Viral HIV-I Vaccine
-
Internat Aids Vaccine Initiati. WO2008118936
-
Internat Aids Vaccine Initiati. Recombinant Modified Ankara Viral HIV-I Vaccine. WO2008118936; 2008
-
(2008)
-
-
-
156
-
-
84859627197
-
Methods for treating cancer with MVA
-
US2011008294
-
Delcayre A, Laus R, Mandl S. Methods for treating cancer with MVA. US2011008294; 2011
-
(2011)
-
-
Delcayre, A.1
Laus, R.2
Mandl, S.3
-
157
-
-
84859651847
-
Recombinan MVA strains as potential vaccines against p. falciparum Malaria
-
US2006127413
-
Sutter G, Bujard H, Westerfeld N, et al. Recombinan MVA strains as potential vaccines against p. falciparum Malaria. US2006127413; 2006
-
(2006)
-
-
Sutter, G.1
Bujard, H.2
Westerfeld, N.3
-
158
-
-
84859627195
-
Recombinant Modified Vaccinia Virus Measles Vaccine
-
US2011052627
-
Chaplin P. Recombinant Modified Vaccinia Virus Measles Vaccine. US2011052627; 2011
-
(2011)
-
-
Chaplin, P.1
-
159
-
-
4444260256
-
Comparative immunogenicity analysis of modified vaccinia Ankara vectors expressing native or modified forms of hepatitis C virus E1 and E2 glycoproteins
-
Abraham JD, Himoudi N, Kien F, et al. Comparative immunogenicity analysis of modified vaccinia Ankara vectors expressing native or modified forms of hepatitis C virus E1 and E2 glycoproteins. Vaccine 2004;22(29--30):3917-28
-
(2004)
Vaccine
, vol.22
, Issue.29-30
, pp. 3917-3928
-
-
Abraham, J.D.1
Himoudi, N.2
Kien, F.3
-
160
-
-
33947409611
-
Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity
-
DOI 10.1002/hep.21573
-
Rollier CS, Paranhos-Baccala G, Verschoor EJ, et al. Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity. Hepatology 2007;45:602-13 (Pubitemid 46450611)
-
(2007)
Hepatology
, vol.45
, Issue.3
, pp. 602-613
-
-
Rollier, C.S.1
Paranhos-Baccala, G.2
Verschoor, E.J.3
Verstrepen, B.E.4
Drexhage, J.A.R.5
Fagrouch, Z.6
Berland, J.-L.7
Komurian-Pradel, F.8
Duverger, B.9
Himoudi, N.10
Staib, C.11
Meyr, M.12
Whelan, M.13
Whelan, J.A.14
Adams, V.A.15
Larrea, E.16
Riezu, J.I.17
Lasarte, J.J.18
Bartosch, B.19
Cosset, F.-L.20
Spaan, W.J.M.21
Diepolder, H.M.22
Pape, G.R.23
Sutter, G.24
Inchauspe, G.25
Heeney, J.L.26
more..
-
161
-
-
81855218444
-
Composition comprising the polyprotein NS3/NS4 and the polypeptide NS5B of HCV, expression vectors including the corresponding nucleic sequences and their therapeutic use
-
Transgene SA. US2007269460
-
Transgene SA. Composition comprising the polyprotein NS3/NS4 and the polypeptide NS5B of HCV, expression vectors including the corresponding nucleic sequences and their therapeutic use. US2007269460; 2007
-
(2007)
-
-
-
162
-
-
34748832365
-
An accelerated vaccine schedule with a poly-antigenic hepatitis C virus MVA-based candidate vaccine induces potent, long lasting and in vivo cross-reactive T cell responses
-
DOI 10.1016/j.vaccine.2007.08.020, PII S0264410X07009437
-
Fournillier A, Gerossier E, Evlashev A, et al. An accelerated vaccine schedule with a poly-antigenic hepatitis C virus MVA-based candidate vaccine induces potent, long lasting and in vivo cross-reactive T cell responses. Vaccine 2007;25:7339-53 (Pubitemid 47484019)
-
(2007)
Vaccine
, vol.25
, Issue.42
, pp. 7339-7353
-
-
Fournillier, A.1
Gerossier, E.2
Evlashev, A.3
Schmitt, D.4
Simon, B.5
Chatel, L.6
Martin, P.7
Silvestre, N.8
Balloul, J.M.9
Barry, R.10
Inchauspe, G.11
-
163
-
-
84859627194
-
-
ClinicalTrials.gov Identifier: NCT00529321. Available from: Accessed on January 2012 This web site provides the results of the phase I studies on TG4040 HCV vaccine
-
ClinicalTrials.gov Identifier: NCT00529321. Available from: http://clinicaltrials.gov/ct2/show/NCT00529321 [Accessed on January 2012] This web site provides the results of the phase I studies on TG4040 HCV vaccine.
-
-
-
-
164
-
-
84859647677
-
Recombinant Alphavirus vectors and methods of using same
-
US2008096274
-
Li G. Recombinant Alphavirus vectors and methods of using same. US2008096274; 2008
-
(2008)
-
-
Li, G.1
-
165
-
-
84859641984
-
Preparation of Infectious HCV-Like Particles
-
KR20030013585
-
Chul Joong K. Preparation of Infectious HCV-Like Particles. KR20030013585. 2003
-
(2003)
-
-
Chul Joong, K.1
-
166
-
-
47749130475
-
+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5
-
DOI 10.1128/JVI.02743-07
-
Lin Y, Kwon T, Polo J, et al. Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5. J Virol 2008;82(15):7492-503 (Pubitemid 352031217)
-
(2008)
Journal of Virology
, vol.82
, Issue.15
, pp. 7492-7503
-
-
Lin, Y.1
Kwon, T.2
Polo, J.3
Zhu, Y.-F.4
Coates, S.5
Crawford, K.6
Dong, C.7
Wininger, M.8
Hall, J.9
Selby, M.10
Coit, D.11
Medina-Selby, A.12
McCoin, C.13
Ng, P.14
Drane, D.15
Chien, D.16
Han, J.17
Vajdy, M.18
Houghton, M.19
-
167
-
-
63449109294
-
T-cell vaccines that elicit effective immune responses against HCV in chimpanzees may create greater immune pressure for viral mutation
-
Zubkova I, Choi YH, Chang E, et al. T-cell vaccines that elicit effective immune responses against HCV in chimpanzees may create greater immune pressure for viral mutation. Vaccine 2009;27(19):2594-602
-
(2009)
Vaccine
, vol.27
, Issue.19
, pp. 2594-2602
-
-
Zubkova, I.1
Choi, Y.H.2
Chang, E.3
-
168
-
-
0035031781
-
Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity
-
DOI 10.1038/87974
-
Stubbs AC, Martin KS, Coeshott C, et al. Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity. Nat Med 2001;7(5):625-9 (Pubitemid 32448332)
-
(2001)
Nature Medicine
, vol.7
, Issue.5
, pp. 625-629
-
-
Stubbs, A.C.1
Martin, K.S.2
Coeshott, C.3
Skaates, S.V.4
Kuritzkes, D.R.5
Bellgrau, D.6
Franzusoff, A.7
Duke, R.C.8
Wilson, C.C.9
-
169
-
-
77951616617
-
Yeast-based vaccine for inducing an immune response
-
GlobeImmune, Inc. WO2007092792
-
GlobeImmune, Inc. Yeast-based vaccine for inducing an immune response. WO2007092792; 2007
-
(2007)
-
-
-
170
-
-
81855199086
-
Yeast-Based Therapeutic for Chronic Hepatitis C Infection
-
GlobeImmune, Inc. US2010150963
-
GlobeImmune, Inc. Yeast-Based Therapeutic for Chronic Hepatitis C Infection. US2010150963; 2010
-
(2010)
-
-
-
171
-
-
33846088350
-
Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and Core proteins
-
DOI 10.1016/j.vaccine.2006.10.035, PII S0264410X06011716
-
Haller AA, Lauer GM, King TH, et al. Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and Core proteins. Vaccine 2007;25:1452-63 (Pubitemid 46074294)
-
(2007)
Vaccine
, vol.25
, Issue.8
, pp. 1452-1463
-
-
Haller, A.A.1
Lauer, G.M.2
King, T.H.3
Kemmler, C.4
Fiolkoski, V.5
Lu, Y.6
Bellgrau, D.7
Rodell, T.C.8
Apelian, D.9
Franzusoff, A.10
Duke, R.C.11
-
172
-
-
84859651846
-
-
ClinicalTrials.gov Identifier: NCT00124215. Available from: and yeast pages of globeimmune: http://www.homeyeastinfectionremedy.org/yeast-infection- treatment/globeimmuneexpands- gi-5005-02-phase-2b-trial-to-include-additional- treatment-naive-il28btt-subjects-with-chronic-genotype-1-hcv/ [Accessed on January 2012]
-
ClinicalTrials.gov Identifier: NCT00124215. Available from: http://clinicaltrials.gov/ct2/show/ NCT00124215 and yeast pages of globeimmune: http://www.homeyeastinfectionremedy.org/yeast-infection-treatment/ globeimmuneexpands- gi-5005-02-phase-2b-trial-to-include-additional-treatment- naive-il28btt-subjects-with-chronic-genotype-1-hcv/ [Accessed on January 2012]
-
-
-
-
173
-
-
77951553269
-
Recent advances in mucosal delivery of vaccines: Role of mucoadhesive/biodegradable polymeric carriers
-
Mishra N, Goyal AK, Tiwari S, et al. Recent advances in mucosal delivery of vaccines: role of mucoadhesive/biodegradable polymeric carriers. Expert Opin Ther Patents 2010;20(5):661-79
-
(2010)
Expert Opin Ther Patents
, vol.20
, Issue.5
, pp. 661-679
-
-
Mishra, N.1
Goyal, A.K.2
Tiwari, S.3
-
174
-
-
67649432630
-
Powder compositions
-
Powderject Vaccines, Inc. WO2001093829
-
Powderject Vaccines, Inc. Powder compositions. WO2001093829; 2001
-
(2001)
-
-
-
175
-
-
84859651845
-
Transdermal Formulations Containing Hepatitis C Virus Immunogens
-
Tripep AB. WO2008004992
-
Tripep AB. Transdermal Formulations Containing Hepatitis C Virus Immunogens. WO2008004992; 2008
-
(2008)
-
-
-
176
-
-
0034766336
-
Oral immunization with HCV-NS3-transformed Salmonella: Induction of HCV-specific CTL in a transgenic mouse model
-
Wedemeyer H, Gagneten S, Davis A, et al. Oral immunization with HCV-NS3-transformed salmonella: induction of HCV-specific CTL in a transgenic mouse model. Gastroenterology 2001; 121(5):1158-66 (Pubitemid 33022096)
-
(2001)
Gastroenterology
, vol.121
, Issue.5
, pp. 1158-1166
-
-
Wedemeyer, H.1
Gagneten, S.2
Davis, A.3
Bartenschlager, R.4
Feinstone, S.5
Rehermann, B.6
-
177
-
-
79955087105
-
Oral immunization with attenuated Salmonella carrying a co-expression plasmid encoding the core and E2 proteins of hepatitis C virus capable of inducing cellular immune responses and neutralizing antibodies in mice
-
Cao J, Chen Z, Ren Y, et al. Oral immunization with attenuated Salmonella carrying a co-expression plasmid encoding the core and E2 proteins of hepatitis C virus capable of inducing cellular immune responses and neutralizing antibodies in mice. Vaccine 2011;29(20):3714-23
-
(2011)
Vaccine
, vol.29
, Issue.20
, pp. 3714-3723
-
-
Cao, J.1
Chen, Z.2
Ren, Y.3
-
178
-
-
79953704799
-
Transgenic crops for the production of recombinant vaccines and anti-microbial antibodies
-
Peters J, Stoger E. Transgenic crops for the production of recombinant vaccines and anti-microbial antibodies. Hum Vaccin 2011;7(3):367-74
-
(2011)
Hum Vaccin
, vol.7
, Issue.3
, pp. 367-374
-
-
Peters, J.1
Stoger, E.2
-
179
-
-
0034531322
-
Development of a plant-derived subunit vaccine candidate against hepatitis C virus
-
DOI 10.1007/s007050070008
-
Nemchinov LG, Liang TJ, Rifaat MM, et al. Development of a plant-derived subunit vaccine candidate against hepatitis C virus. Arch Virol 2000;145(12):2557-73 (Pubitemid 32062441)
-
(2000)
Archives of Virology
, vol.145
, Issue.12
, pp. 2557-2573
-
-
Nemchinov, L.G.1
Liang, T.J.2
Rifaat, M.M.3
Mazyad, H.M.4
Hadidi, A.5
Keith, J.M.6
-
180
-
-
77950968711
-
In vitro stability of Cucumber mosaic virus nanoparticles carrying a Hepatitis C virus-derived epitope under simulated gastrointestinal conditions and in vivo efficacy of an edible vaccine
-
Nuzzaci M, Vitti A, Condelli V, et al. In vitro stability of Cucumber mosaic virus nanoparticles carrying a Hepatitis C virus-derived epitope under simulated gastrointestinal conditions and in vivo efficacy of an edible vaccine. J Virol Methods 2010; 165(2):211-15
-
(2010)
J Virol Methods
, vol.165
, Issue.2
, pp. 211-215
-
-
Nuzzaci, M.1
Vitti, A.2
Condelli, V.3
-
181
-
-
84859641985
-
HCV composite multi-epitope transgene plan oral vaccine
-
Qingdao Science Technology Uni. CN101070544
-
Qingdao Science Technology Uni. HCV composite multi-epitope transgene plan oral vaccine. CN101070544; 2007
-
(2007)
-
-
-
182
-
-
0037716983
-
Recombinant hepatitis B vaccine (Engerix-B): A review of its immunogenicity and protective efficacy against hepatitis B
-
DOI 10.2165/00003495-200363100-00006
-
Keating GM, Noble S. Recombinant hepatitis B (Engerix-B) vaccine: a review of its immunogenicity and protective efficacy against hepatitis B. Drugs 2003;63:1021-51 (Pubitemid 36575466)
-
(2003)
Drugs
, vol.63
, Issue.10
, pp. 1021-1051
-
-
Keating, G.M.1
Noble, S.2
Averhoff, F.M.3
Belloni, C.4
Duval, B.5
Goldwater, P.N.6
Hall, A.J.7
Honorati, M.C.8
Kallinowski, B.9
Leroux-Roels, G.10
Poovorawan, Y.11
-
183
-
-
67349209526
-
Chimeric hepatitis B and C viruses envelope proteins can form subviral particles: Implications for the design of new vaccine strategies
-
Patient R, Hourioux C, Vaudin P, et al. Chimeric hepatitis B and C viruses envelope proteins can form subviral particles: implications for the design of new vaccine strategies. New Biotechnol 2009;25(4):226-34
-
(2009)
New Biotechnol
, vol.25
, Issue.4
, pp. 226-234
-
-
Patient, R.1
Hourioux, C.2
Vaudin, P.3
-
184
-
-
67649416165
-
HBV/HCV virus-like particle
-
Chiron Corp. US6740323; 2004.and EP1535628
-
Chiron Corp. HBV/HCV virus-like particle. US6740323; 2004.and EP1535628; 2005
-
(2005)
-
-
-
185
-
-
84859641740
-
Yeast strain for preparing PreS-E1-E2 vaccine of hepatitis B and hepatitis C virus and preparation method thereof
-
Univ Wuhan (CN). CN1908157
-
Univ Wuhan (CN). Yeast strain for preparing PreS-E1-E2 vaccine of hepatitis B and hepatitis C virus and preparation method thereof. CN1908157; 2007
-
(2007)
-
-
-
186
-
-
81855163728
-
Novel fusion proteins and use thereof for preparing Hepatitis C Vaccines
-
Univ Francois Rabelais de Tour (FR). WO2009153518
-
Univ Francois Rabelais de Tour (FR). Novel fusion proteins and use thereof for preparing Hepatitis C Vaccines. WO2009153518; 2009
-
(2009)
-
-
-
187
-
-
0032944906
-
Hepatitis C virus core protein fused to hepatitis B virus core antigen forserological diagnosis of both hepatitis C and hepatitis B infections by ELISA
-
Wu CL, Leu TS, Chang TT, et al. Hepatitis C virus core protein fused to hepatitis B virus core antigen forserological diagnosis of both hepatitis C and hepatitis B infections by ELISA. J Med Virol 1999;57:104-10
-
(1999)
J Med Virol
, vol.57
, pp. 104-110
-
-
Wu, C.L.1
Leu, T.S.2
Chang, T.T.3
-
188
-
-
0028924312
-
Localization and reactivity of an immunodominant domain in the NS3 region of hepatitis C virus
-
Claeys H, Volckaerts A, Mertens W, et al. Localization and reactivity of an immunodominant domain in the NS3 region of hepatitis C virus. J Med Virol 1995;45:273-81
-
(1995)
J Med Virol
, vol.45
, pp. 273-281
-
-
Claeys, H.1
Volckaerts, A.2
Mertens, W.3
-
189
-
-
33646128931
-
Recombinant virus-like particles as a carrier of B- And T-cell epitopes of hepatitis C virus
-
Mihailova M, Boos M, Petrovskis I, et al. Recombinant virus-like particles as a carrier of B- and T-cell epitopes of hepatitis C virus. Vaccine 2006;24:4369-77
-
(2006)
Vaccine
, vol.24
, pp. 4369-4377
-
-
Mihailova, M.1
Boos, M.2
Petrovskis, I.3
-
190
-
-
67649432641
-
Chimeric antigen gene of hepatitis B and hepatitis C and its nucleic acid vaccine
-
Univ First Hospital Jilin CN1690206
-
Univ First Hospital Jilin. Chimeric antigen gene of hepatitis B and hepatitis C and its nucleic acid vaccine. CN1690206; 2005
-
(2005)
-
-
-
191
-
-
81855199072
-
Immunogen Platform
-
Tripep AB. US2009214593
-
Tripep AB. Immunogen Platform. US2009214593; 2009
-
(2009)
-
-
|