Correlated Immunohistochemical and Cytological Assays for the Prediction of Hematogenous Dissemination of Breast Cancer

Journal of Histochemistry and Cytochemistry

Volumn 60, Issue 3, 2012, Pages 168-173

  Oktay, Maja H ^a   Gertler, Frank B ^b   Liu, Yi Fang ^c   Rohan, Thomas E ^d   Condeelis, John S ^d   Jones, Joan G ^c  

^a MONTEFIORE MEDICAL CENTER   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

breast cancer; fine needle aspiration (FNA) biopsy; immunohistochemical markers; metastasis; tumor microenvironment

Indexed keywords

CD31 ANTIGEN; CD68 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ISOPROTEIN; PROTEIN MENA; REGULATOR PROTEIN; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; ENAH PROTEIN, HUMAN;

ASPIRATION BIOPSY; BREAST CANCER; BREAST CARCINOMA; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER PATIENT; CANCER RISK; CANCER STAGING; CAUSE OF DEATH; CELL MOTILITY; CELL PROLIFERATION; CLINICAL ASSESSMENT; CLINICAL PRACTICE; CONFIDENCE INTERVAL; CORRELATION ANALYSIS; CYTOLOGY; GOLD STANDARD; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; METASTASIS; NATURAL SELECTION; NON PROFIT ORGANIZATION; NONHUMAN; PREDICTION; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; REVIEW; RISK ASSESSMENT; SCID MOUSE; TUMOR MICROENVIRONMENT; TUMOR VOLUME; BIOASSAY; BIOSYNTHESIS; BREAST TUMOR; CELL MOTION; FEMALE; METHODOLOGY; MOLECULAR IMAGING; NEEDLE BIOPSY; PATHOLOGY; RISK; STAINING;

BIOLOGICAL ASSAY; BIOPSY, FINE-NEEDLE; BREAST NEOPLASMS; CELL MOVEMENT; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROFILAMENT PROTEINS; MOLECULAR IMAGING; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RISK; STAINING AND LABELING; TUMOR MICROENVIRONMENT;

EID: 84859640858     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155411435153     Document Type: Review

References (32)

1. Breast cancer facts & figures. Atlanta: American Cancer Society; 2010:2009-2010.
2. Condeelis J,Pollard JW.Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.Cell. 2006;124:263-266.
3. Condeelis J,Segall JE.Intravital imaging of cell movement in tumours.Nat Rev Cancer. 2003;3:921-930.
4. Condeelis J,Singer RH,Segall JE.The great escape: when cancer cells hijack the genes for chemotaxis and motility.Annu Rev Cell Dev Biol. 2005;21:695-718.
5. Di Modugno F,Bronzi G,Scanlan MJ,Del Bello D,Cascioli S,Venturo I,Botti C,Nicotra MR,Mottolese M,Natali PG,Santoni A,Jager E,Nistico P.Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response.Int J Cancer. 2004;109:909-918.
6. Di Modugno F,DeMonte L,Balsamo M,Bronzi G,Nicotra MR,Alessio M,Jager E,Condeelis JS,Santoni A,Natali PG,Nistico P.Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines.Cancer Res. 2007;67:2657-2665.
7. Di Modugno F,Mottolese M,Di Benedetto A,Conidi A,Novelli F,Perracchio L,Venturo I,Botti C,Jager E,Santoni A,Natali PG,Nistico P.The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors.Clin Cancer Res. 2006;12:1470-1478.
8. Gertler F,Condeelis J.Metastasis: tumor cells becoming MENAcing.Trends Cell Biol. 2011;21:81-90.
9. Gertler FB,Niebuhr K,Reinhard M,Wehland J,Soriano P.Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.Cell. 1996;87:227-239.
10. Giavazzi R,Alessandri G,Spreafico F,Garattini S,Mantovani A.Metastasizing capacity of tumour cells from spontaneous metastases of transplanted murine tumours.Br J Cancer. 1980;42:462-472.
11. Giraudo E,Inoue M,Hanahan D.An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.J Clin Invest. 2004;114:623-633.
12. Goswami S,Philippar U,Sun D,Patsialou A,Avraham J,Wang W,Di Modugno F,Nistico P,Gertler FB,Condeelis JS.Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.Clin Exp Metastasis. 2009;26:153-159.
13. Kedrin D,van Rheenen J,Hernandez L,Condeelis J,Segall JE.Cell motility and cytoskeletal regulation in invasion and metastasis.J Mammary Gland Biol Neoplasia. 2007;12:143-152.
14. Krause M,Dent EW,Bear JE,Loureiro JJ,Gertler FB.Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration.Annu Rev Cell Dev Biol. 2003;19:541-564.
15. Leek RD,Harris AL.Tumor-associated macrophages in breast cancer.J Mammary Gland Biol Neoplasia. 2002;7:177-189.
16. Lin EY,Jones JG,Li P,Zhu L,Whitney KD,Muller WJ,Pollard JW.Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases.Am J Pathol. 2003;163:2113-2126.
17. Mantovani A,Giavazzi R,Polentarutti N,Spreafico F,Garattini S.Divergent effects of macrophage toxins on growth of primary tumors and lung metastases in mice.Int J Cancer. 1980;25:617-620.
18. Milas L,Peters LJ,Ito H.Spontaneous metastasis: random or selective?.Clin Exp Metastasis. 1983;1:309-315.
19. Philippar U,Roussos ET,Oser M,Yamaguchi H,Kim HD,Giampieri S,Wang Y,Goswami S,Wyckoff JB,Lauffenburger DA,Sahai E,Condeelis JS,Gertler FB.A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.Dev Cell. 2008;15:813-828.
20. Ramaswamy S,Ross KN,Lander ES,Golub TR.A molecular signature of metastasis in primary solid tumors.Nat Genet. 2003;33:49-54.
21. Robinson BD,Sica GL,Liu YF,Rohan TE,Gertler FB,Condeelis JS,Jones JG.Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination.Clin Cancer Res. 2009;15:2433-2441.
22. Roussos ET,Balsamo M,Alford SK,Wyckoff JB,Gligorijevic B,Wang Y,Pozzuto M,Stobezki R,Goswami S,Segall JE,Lauffenburger DA,Bresnick AR,Gertler FB,Condeelis JS.Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer.J Cell Sci. 2011a;124:2120-2131.
23. Roussos ET,Condeelis JS,Patsialou A.Chemotaxis in cancer.Nat Rev Cancer. 2011b;11:573-587.
24. Roussos ET,Goswami S,Balsamo M,Wang Y,Stobezki R,Adler E,Robinson BD,Jones JG,Gertler FB,Condeelis JS,Oktay MH.Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM.Clin Exp Metastasis. 2011c;28:515-527.
25. Roussos ET,Wang Y,Wyckoff JB,Sellers RS,Wang W,Li J,Pollard JW,Gertler FB,Condeelis JS.Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors.Breast Cancer Res. 2010;12:R101.
26. van de Vijver MJ,He YD,van't Veer LJ,Dai H,Hart AA,Voskuil DW,Schreiber GJ,Peterse JL,Roberts C,Marton MJ,Parrish M,Atsma D,Witteveen A,Glas A,Delahaye L,van der Velde T,Bartelink H,Rodenhuis S,Rutgers ET,Friend SH,Bernards R.A gene-expression signature as a predictor of survival in breast cancer.N Engl J Med. 2002;347:1999-2009.
27. Wang W,Goswami S,Lapidus K,Wells AL,Wyckoff JB,Sahai E,Singer RH,Segall JE,Condeelis JS.Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.Cancer Res. 2004;64:8585-8594.
28. Wang W,Goswami S,Sahai E,Wyckoff JB,Segall JE,Condeelis JS.Tumor cells caught in the act of invading: their strategy for enhanced cell motility.Trends Cell Biol. 2005;15:138-145.
29. Wang W,Wyckoff JB,Goswami S,Wang Y,Sidani M,Segall JE,Condeelis JS.Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors.Cancer Res. 2007;67:3505-3511.
30. Wyckoff J,Segall J,Condeelis JSingle cell imaging in animal tumors in vivo. Cold Spring Harbor, NY: Cold Spring Harbor Laboratories Press; 2004:.
31. Wyckoff JB,Wang Y,Lin EY,Li JF,Goswami S,Stanley ER,Segall JE,Pollard JW,Condeelis J.Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors.Cancer Res. 2007;67:2649-2656.
32. Yamaguchi H,Pixley F,Condeelis J.Invadopodia and podosomes in tumor invasion.Eur J Cell Biol. 2006;85:213-218.