Alveolar diffusion and pharmacokinetics of linezolid administered in continuous infusion to critically ill patients with ventilator-associated pneumonia

Journal of Antimicrobial Chemotherapy

Volumn 67, Issue 5, 2012, Pages 1207-1210

  Boselli, Emmanuel ^a,b   Breilh, Dominique ^b   Caillault Sergent, Aurore ^a   Djabarouti, Sarah ^b   Guillaume, Christian ^a   Xuereb, Fabien ^b   Bouvet, Lionel ^a   Rimmelé, Thomas ^a   Saux, Marie Claude ^b   Allaouchiche, Bernard ^a  

^a UNIVERSITÉ DE LYON   (France)

^b HAUT LÉVÊQUE HOSPITAL   (France)

Author keywords

ICU; Intensive care; VAP

Indexed keywords

LINEZOLID;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTINUOUS INFUSION; CRITICALLY ILL PATIENT; EPITHELIAL LINING FLUID; EPITHELIUM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTENSIVE CARE; LUNG DIFFUSION; LUNG LAVAGE; MALE; OPEN STUDY; PROSPECTIVE STUDY; VENTILATOR ASSOCIATED PNEUMONIA;

ACETAMIDES; ADULT; ANTI-BACTERIAL AGENTS; CRITICAL ILLNESS; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; OXAZOLIDINONES; PNEUMONIA, STAPHYLOCOCCAL; PNEUMONIA, VENTILATOR-ASSOCIATED; PROSPECTIVE STUDIES; PULMONARY ALVEOLI; SERUM; STAPHYLOCOCCUS AUREUS;

EID: 84859562225     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks022     Document Type: Article

References (12)

1. Diekema DJ, Jones RN. Oxazolidinone antibiotics. Lancet 2001; 358: 1975-82.
2. Kalil AC, Murthy MH, Hermsen ED et al. Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: a systematic review and meta-analysis. Crit Care Med 2010; 38: 1802-8.
3. Jacqueline C, Batard E, Perez L et al. In vivo efficacy of continuous infusion versus intermittent dosing of linezolid compared to vancomycin in a methicillin-resistant Staphylococcus aureus rabbit endocarditis model. Antimicrob Agents Chemother 2002; 46: 3706-11.
4. Adembri C, Fallani S, Cassetta MI et al. Linezolid pharmacokinetic/pharmacodynamic profile in critically ill septic patients: intermittent versus continuous infusion. Int J Antimicrob Agents 2008; 31: 122-9.
5. Boselli E, Breilh D, Rimmelé T et al. Pharmacokinetics and intrapulmonary concentrations of linezolid administered to critically ill patients with ventilator-associated pneumonia. Crit Care Med 2005; 33: 1529-33.
6. Boselli E, Breilh D, Djabarouti S et al. Reliability of mini-bronchoalveolar lavage for the measurement of epithelial lining fluid concentrations of tobramycin in critically ill patients. Intensive Care Med 2007; 33: 1519-23.
7. Toutain J, Boselli E, Djabarouti S et al. Determination of linezolid in plasma and bronchoalveolar lavage by high-performance liquid chromatography with ultraviolet detection using a fully automated extraction method. J Chromatogr B Analyt Technol Biomed Life Sci 2004; 813: 145-50.
8. Conte JE Jr, Golden JA, Kipps J et al. Intrapulmonary pharmacokinetics of linezolid. Antimicrob Agents Chemother 2002; 46: 1475-80.
9. Honeybourne D, Tobin C, Jevons G et al. Intrapulmonary penetration of linezolid. J Antimicrob Chemother 2003; 51: 1431-4.
10. Buerger C, Plock N, Dehghanyar P et al. Pharmacokinetics of unbound linezolid in plasma and tissue interstitium of critically ill patients after multiple dosing using microdialysis. Antimicrob Agents Chemother 2006; 50: 2455-63.
11. Rayner CR, Forrest A, Meagher AK et al. Clinical pharmacodynamics of linezolid in seriously ill patients treated in a compassionate use programme. Clin Pharmacokinet 2003; 42: 1411-23.
12. Kiem S, Schentag JJ. Interpretation of antibiotic concentration ratios measured in epithelial lining fluid. Antimicrob Agents Chemother 2008; 52: 24-36.