Pulmonary administration of interferon beta-1a-Fc fusion protein in non-human primates using an immunoglobulin transport pathway

Journal of Interferon and Cytokine Research

Volumn 32, Issue 4, 2012, Pages 178-184

  Vallee, Sebastien ^a   Rakhe, Swapnil ^a   Reidy, Thomas ^a   Walker, Sandra ^a   Lu, Qi ^a   Sakorafas, Paul ^a   Low, Susan ^b   Bitonti, Alan ^a  

^a BIOGEN   (United States)

^b BIND Biosciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BETA1A INTERFERON; FC RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN; NEOPTERIN; RECOMBINANT BETA INTERFERON; RECOMBINANT BETA1A INTERFERON FC FUSION PROTEIN; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ADMINISTRATION, INHALATION; ANIMALS; CHROMATOGRAPHY, GEL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULINS; INJECTIONS, SUBCUTANEOUS; INTERFERON-BETA; LUNG; MACACA FASCICULARIS; MALE; NEOPTERIN; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS;

PRIMATES;

EID: 84859553266     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2011.0048     Document Type: Article

References (15)

1. Alam J, Goelz S, Rioux P, Scaramucci J, Jones W, McAllister A, Campion M, Rogge M. 1997. Comparative pharmacokinetics and pharmacodynamics of two recombinant human interferon beta-1a (IFN beta-1 a) products administered intramuscularly in healthy male and female volunteers. Pharm Res 14(4):546-549. (Pubitemid 27205021)
2. Bitonti AJ, Dumont JA. 2006. Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway. Adv Drug Deliv Rev 58(9-10):1106-1118. (Pubitemid 44709269)
3. Bitonti AJ, Dumont JA, Low SC, Peters RT, Kropp KE, Palombella VJ, Stattel JM, Lu Y, Tan CA, Song JJ, Garcia AM, Simister NE, Spiekermann GM, Lencer WI, Blumberg RS. 2004. Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc Natl Acad Sci USA 101(26):9763-9768. (Pubitemid 38869310)
4. Hu X, Olivier K, Polack E, Crossman M, Zokowski K, Gronke RS, Parker S, Li Z, Nestorov I, Baker DP, Clarke J, Subramanyam M. 2011. In vivo pharmacology and toxicology evaluation of polyethylene glycol-conjugated interferon {beta}-1a. J Pharmacol Exp Ther 338(3):984-996.
5. Mager DE, Neuteboom B, Efthymiopoulos C, Munafo A, Jusko WJ. 2003. Receptor-mediated pharmacokinetics and pharmacodynamics of interferon-beta1a in monkeys. J Pharmacol Exp Ther 306(1):262-270. (Pubitemid 36734381)
6. Mager DE, Neuteboom B, Jusko WJ. 2005. Pharmacokinetics and pharmacodynamics of PEGylated IFN-beta 1a following subcutaneous administration in monkeys. Pharm Res 22(1):58-61. (Pubitemid 40558146)
7. Martin PL, Vaidyanathan S, Lane J, Rogge M, Gillette N, Niggemann B, Green J. 2002. Safety and systemic absorption of pulmonary delivered human IFN-beta1a in the nonhuman primate: comparison with subcutaneous dosing. J Interferon Cytokine Res 22(6):709-717. (Pubitemid 35034531)
8. Pepinsky RB, LePage DJ, Gill A, Chakraborty A, Vaidyanathan S, Green M, Baker DP, Whalley E, Hochman PS, Martin P. 2001. Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity. J Pharmacol Exp Ther 297(3):1059-1066. (Pubitemid 32472504)
9. Pestka S, Krause CD, Walter MR. 2004. Interferons, interferon-like cytokines, and their receptors. Immunol Rev 202:8-32. (Pubitemid 39576902)
10. Pestka S, Langer JA, Zoon KC, Samuel CE. 1987. Interferons and their actions. Annu Rev Biochem 56:727-777. (Pubitemid 17105465)
11. Peters RT, Low SC, Kamphaus GD, Dumont JA, Amari JV, Lu Q, Zarbis-Papastoitsis G, Reidy TJ, Merricks EP, Nichols TC, Bitonti AJ. 2010. Prolonged activity of factor IX as a monomeric Fc fusion protein. Blood 115(10):2057-2064.
12. Sakagami M, Omidi Y, Campbell L, Kandalaft LE, Morris CJ, Barar J, Gumbleton M. 2006. Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung. Pharm Res 23(2):270-279. (Pubitemid 43237858)
13. Salmon P, Le Cotonnec JY, Galazka A, Abdul-Ahad A, Darragh A. 1996. Pharmacokinetics and pharmacodynamics of recombinant human interferon-beta in healthy male volunteers. J Interferon Cytokine Res 16(10):759-764. (Pubitemid 26389112)
14. Weinstock-Guttman B, Ransohoff RM, Kinkel RP, Rudick RA. 1995. The interferons: biological effects, mechanisms of action, and use in multiple sclerosis. Ann Neurol 37(1):7-15.
15. Wills RJ. 1990. Clinical pharmacokinetics of interferons. Clin Pharmacokinet 19(5):390-399.