Preparation and characterization of theophylline-chitosan beads as an aapproach to colon delivery

Iranian Journal of Pharmaceutical Research

Volumn 3, Issue 2, 2004, Pages 73-80

  Avadi, Mohammad Reza ^a,b   Ghassemi, Amir Hossein ^c   Sadeghi, Assal Mir Mohammad ^b   Erfan, Mohammad ^a   Akbarzadeh, Azim ^d   Moghimi, Hamid Reza ^a   Rafiee Tehrani, Mortaza ^c  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Hakim Pharmaceutical Company   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Bead; Chitosan; Colon; Drug delivery; Theophylline

Indexed keywords

EID: 84859551024     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: 10.22037/IJPR.2010.579     Document Type: Article

References (19)

1. Brugnerotto J, Lizardi J, Goycoolea FM, Arguelles-Monal W, Desbrieres J and Rinaudo M. An infrared investigation in relation with chitin and chitosan characterization. Polymer (2001) 42: 3569-3580
2. Remunan-Lopez C, Portero A, Vila-Jato JLand Alonso MJ. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J. Control Release (1998) 55: 143-152
3. Sabins S and Block LH. Chitosan as an enabling excipient for drug delivery systems I. Molecular modifications. Biological Macromolecule (2000) 27: 181-186
4. Deuchi K, Kanamichi O, Imasato Yand kobayashi E. Decreasing effect of chitosan on the apparent fat digestibility by rats fed on a high-fat diet. Bioscience Biotechnology Biochemistry (1994) 58: 1613-1616
5. Nagai T, Sawayanagi Yand Nambu N. Application of chitin and chitosan to pharmaceutical preparations. In chitin, chitosan and related enzymes, Zikakis J P. (Ed) Academic Press, Inc. (1984) 21-40
6. Nigalaye AG, Adusumilli Pand Bolton S. Investigation of prolonged drug release from matrix formulation of chitosan. Drug Develop. Ind. Pharm. (1990) 16: 449-467
7. Miyazaki T, Komuro T, Yomota C and Okada S. Usage of chitosan as a pharmaceutical material: effectiveness as an additional additive of sodium alginate. Eisei Shikenjo Hokoku. (1990) 108: 95-97
8. Kawashima Y, Handa T, Takenaka H, Lin SYand Ando Y. Novel method for the preparation of controlled release theophylline granules coated with a polyelectrolyte complex of sodium phosphate-chitosan. J. Pharm. Sci. (1985) 74: 264-268
9. Bodmeier R, Oh KH and Pramar Y. Preparation and evaluation of drug containing chitosan beads. Drug Develop. Ind. Pharm. (1989) 15: 1475-1494
10. Kawashima Y, Handa T, Kasai A, Takenaka H and Lin SY. The effect of thickness and hardness of the coating film on the drug release rate of theophylline granules coated with chitosan-sodium tripolyphosphate complex. Chem. Pharm. Bull. (1985) 33: 2469-2474
11. Aral C and Akbuga J. Alternative approach to the preparation of chitosan beads. Int. J. Pharm. (1998) 168: 9-15
12. Shu XZ and Zhu KJ. Anovel approach to prepare TPP/Chitosan complex beads for controlled release drug delivery. Int. J. Pharm. (2000)201: 51-58
13. Sezer AD and Akbuga J. Controlled release of piroxicam from chitosan beads. Int. J. Pharm. (1995) 121: 113-116
14. Kim S Y, Cho S M, Lee YM and Kim S J. Thermo and pH-responsive of graft copolymer and blend based on chitosan and N-isopropylacrylamide. J. App. polymer sci. (2000) 78: 1381-1391
15. Domszy JG and Roberts GAF. Evaluation of infrared spectroscopic techniques for analysing chitosan. Macromolecule Chemistry (1985) 186: 1671-1677
16. Wang W, Bo S, Li S and Qin W. Determination of the Mark-Howink equation for chitosans with different degrees of deacetylation. Int. J. Biol. Macromolecule (1991) 13: 281-285
17. Gupta KC, Ravi NMV. and Kumar R. Drug release behavior of beads and microgranules of chitosan. Biomaterials (2000) 2: 1115-1119
18. Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv. (1985) 60 (4): 110-111
19. Takka S, Ocak OH and Acarturk F. Formulation and investigation of nicardipine HCl-alginate gel beads with factorial design-based studies. Eur. J. Pharm. Sci. (1998) 6: 241-246