Tranexamic acid for traumatic hemorrhage;Ácido tranexâmico no tratamento da hemorragia no trauma

Revista do Colegio Brasileiro de Cirurgioes

Volumn 39, Issue 1, 2012, Pages 77-80

  da Luz, Luis ^a   Sankarankutty, Ajith ^b   Passos, Edward ^a   Rizoli, Sandro ^a   Fraga, Gustavo P ^c   Nascimento, Bartolomeu ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84859541165     PISSN: 01006991     EISSN: 18094546     Source Type: Journal    
DOI: 10.1590/s0100-69912012000100015     Document Type: Article

References (9)

1. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, et al. Epidemiology of trauma deaths: a reassessment. J Trauma. 1995;38(2):185-93.
2. Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65(4):748-54.
3. Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, McClelland B, et al. Antifibrinolytic use for minimizing perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2007;4:CD001886.
4. CRASH-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomized, placebocontrolled trial. Lancet. 2010;376(9734):23-32.
5. Martin K, Wiesner G, Breuer T, Lange R, Tassani P. The risks of aprotinin and tranexamic acid in cardiac surgery: a one-year followup of 1188 consecutive patients. Anesth Analg. 2008;107(6):1783-90.
6. Syrovets T, Simmet T. Novel aspects and new roles for the serine protease plasmin. Cell Mol Life Sci. 2004;61(7-8):873-85.
7. CRASH-2 collaborators. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377(9771):1096-101, 1101. e1-2.
8. Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military application of tranexamic acid in trauma emergency resuscitation (MATTERs) study. Arch Surg. In Press 2011.
9. Roberts I, Shakur H, Ker K, Coats T, CRASH-2 trial collaborators. Antifibrinolytic therapy for acute traumatic injury. Cochrane Database Syst Rev. 2011;1:CD004896.