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Volumn 14, Issue 2, 2012, Pages 164-176

Update on the treatment of granulomatosis with polyangiitis (Wegener's)

Author keywords

ANCA; Treatment; Vasculitis; Wegener's

Indexed keywords

AZATHIOPRINE; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; GLUCOCORTICOID; METHOTREXATE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PLACEBO; PREDNISONE; RITUXIMAB;

EID: 84859512662     PISSN: 10928464     EISSN: 15343189     Source Type: Journal    
DOI: 10.1007/s11936-012-0165-x     Document Type: Article
Times cited : (19)

References (48)
  • 1
    • 70449213796 scopus 로고
    • Giant cell granuloma of the respiratory tract (Wegener's Granulomatosis)
    • Walton E. Giant cell granuloma of the respiratory tract (Wegener's Granulomatosis). Brit Med J. 1958;2:265-70.
    • (1958) Brit Med J. , vol.2 , pp. 265-270
    • Walton, E.1
  • 2
    • 0014116172 scopus 로고
    • The use of alkylating agents in the treatment of Wegener's granulomatosis
    • Hollander D, Manning RT. The use of alkylating agents in the treatment of Wegener's granulomatosis. Ann Intern Med. 1967;67:393-8.
    • (1967) Ann Intern Med. , vol.67 , pp. 393-398
    • Hollander, D.1    Manning, R.T.2
  • 3
    • 0015764397 scopus 로고
    • Wegener's granulomatosis: Studies in eighteen patients and a review of the literature
    • Fauci A, Wolff S. Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine. 1973;52:535-61.
    • (1973) Medicine. , vol.52 , pp. 535-561
    • Fauci, A.1    Wolff, S.2
  • 4
    • 0020656868 scopus 로고
    • Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years
    • Fauci A, Haynes B, Katz P, Wolff S. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98:76-85. (Pubitemid 13217969)
    • (1983) Annals of Internal Medicine , vol.98 , Issue.1 , pp. 76-85
    • Fauci, A.S.1    Haynes, B.F.2    Katz, P.3    Wolff, S.M.4
  • 5
    • 0026505235 scopus 로고
    • Wegener granulomatosis: An analysis of 158 patients
    • Hoffman GS, Kerr GS, Leavitt RY, et al. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. 1992;116:488-98.
    • (1992) Ann Intern Med. , vol.116 , pp. 488-498
    • Hoffman, G.S.1    Kerr, G.S.2    Leavitt, R.Y.3
  • 7
    • 0033499210 scopus 로고    scopus 로고
    • A staged approach to the treatment of Wegener's granulomatosis: Induction of remission with glucocorticoids and daily cyclophosphamide switching to methotrexate for remission maintenance
    • DOI 10.1002/1529-0131(199912)42:12<2666::AID-ANR24>3.0.CO;2-E
    • Langford CA, Talar-Williams C, Barron KS, et al. A staged approach to the treatment of Wegener's granulomatosis: induction of remission with glucocorticoids and daily cyclophosphamide switching to methotrexate for remission maintenance. Arthritis Rheum. 1999;42:2666-73. (Pubitemid 30327189)
    • (1999) Arthritis and Rheumatism , vol.42 , Issue.12 , pp. 2666-2673
    • Langford, C.A.1    Talar-Williams, C.2    Barron, K.S.3    Sneller, M.C.4
  • 9
    • 78649728808 scopus 로고    scopus 로고
    • Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized controlled trial
    • This study compared azathioprine to mycophenolate mofetil for remission maintenance. Mycophenolate mofetil was associated with a higher rate of relapse than azathioprine but had a comparable rate of adverse events
    • Hiemstra TF, Walsh M, Mahr A, et al. Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial. JAMA. 2010;304:2381-8. This study compared azathioprine to mycophenolate mofetil for remission maintenance. Mycophenolate mofetil was associated with a higher rate of relapse than azathioprine but had a comparable rate of adverse events.
    • (2010) JAMA , vol.304 , pp. 2381-2388
    • Hiemstra, T.F.1    Walsh, M.2    Mahr, A.3
  • 10
    • 77954651554 scopus 로고    scopus 로고
    • Rituximab versus cyclophosphamide for ANCA-associated vasculitis
    • This randomized blinded trial of 197 patients compared rituximab to cyclophosphamide for remission induction of severe GPA and MPA. This randomized blinded trial of 197 patients compared rituximab to cyclophosphamide for remission induction of severe GPA and MPA. Rituximab was found to be as effective as cyclophosphamide for remission induction. This was a pivotal trial that formed the basis for FDA approval of rituximab for GPA and MPA in 2011
    • Stone JH, Merkel PA, Spiera R, et al. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med. 2010;363:221-32. This randomized blinded trial of 197 patients compared rituximab to cyclophosphamide for remission induction of severe GPA and MPA. This randomized blinded trial of 197 patients compared rituximab to cyclophosphamide for remission induction of severe GPA and MPA. Rituximab was found to be as effective as cyclophosphamide for remission induction. This was a pivotal trial that formed the basis for FDA approval of rituximab for GPA and MPA in 2011.
    • (2010) N Engl J Med. , vol.363 , pp. 221-232
    • Stone, J.H.1    Merkel, P.A.2    Spiera, R.3
  • 11
    • 77954632414 scopus 로고    scopus 로고
    • Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis
    • This trial randomized 44 patients at a 3:1 ratio to receive intermittent cyclophosphamide or rituximab following 2 doses of intermittent cyclophosphamide. The trial did not meet its primary endpoint of superiority of rituximab, ?although rituximab appeared as effective as cyclophosphamide. A high mortality rate was seen likely reflecting the older age and renal insufficiency in the study population
    • Jones RB, Tervaert JW, Hauser T, et al. Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N Engl J Med. 2010;363:211-20. This trial randomized 44 patients at a 3:1 ratio to receive intermittent cyclophosphamide or rituximab following 2 doses of intermittent cyclophosphamide. The trial did not meet its primary endpoint of superiority of rituximab, ?although rituximab appeared as effective as cyclophosphamide. A high mortality rate was seen likely reflecting the older age and renal insufficiency in the study population.
    • (2010) N Engl J Med. , vol.363 , pp. 211-220
    • Jones, R.B.1    Tervaert, J.W.2    Hauser, T.3
  • 12
    • 78650784897 scopus 로고    scopus 로고
    • Improved outcome in 445 patients with Wegener's granulomatosis in a German vasculitis center over four decades
    • This study examined the experience with cyclophosphamide in GPA over four decades and described the evolution of use of this agent and the lessons learned regarding safety and efficacy over time
    • Holle JU, Gross WL, Latza U, et al. Improved outcome in 445 patients with Wegener's granulomatosis in a German vasculitis center over four decades. Arthritis Rheum. 2011;63:257-66. This study examined the experience with cyclophosphamide in GPA over four decades and described the evolution of use of this agent and the lessons learned regarding safety and efficacy over time.
    • (2011) Arthritis Rheum. , vol.63 , pp. 257-266
    • Holle, J.U.1    Gross, W.L.2    Latza, U.3
  • 13
    • 66149168812 scopus 로고    scopus 로고
    • Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial
    • This study compared intermittent to daily cyclophosphamide. A similar rate of remission induction was seen although intermittent dosing appeared to be associated with a higher relapse rate. Daily cyclophosphamide had a higher frequency of leukopenia that occurred at times of decreased blood count monitoring. Intermittent cyclophosphamide provided a lower cumulative dose over time. This study suggested that both approaches are acceptable and provided guidance regarding blood count monitoring and cyclophosphamide duration
    • de Groot K, Harper L, Jayne DR et al. Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial. Ann Intern Med. 2009;150:670-80. This study compared intermittent to daily cyclophosphamide. A similar rate of remission induction was seen although intermittent dosing appeared to be associated with a higher relapse rate. Daily cyclophosphamide had a higher frequency of leukopenia that occurred at times of decreased blood count monitoring. Intermittent cyclophosphamide provided a lower cumulative dose over time. This study suggested that both approaches are acceptable and provided guidance regarding blood count monitoring and cyclophosphamide duration.
    • (2009) Ann Intern Med. , vol.150 , pp. 670-680
    • De Groot, K.1    Harper, L.2    Jayne, D.R.3
  • 15
    • 79955561986 scopus 로고    scopus 로고
    • Incidence and predictors of urotoxic adverse events in cyclophosphamide-treated patients with systemic necrotizing vasculitides
    • Le Guenno G, Mahr A, Pagnoux C, et al. Incidence and predictors of urotoxic adverse events in cyclophosphamide-treated patients with systemic necrotizing vasculitides. Arthritis Rheum. 2011;63:1435-45.
    • (2011) Arthritis Rheum. , vol.63 , pp. 1435-1445
    • Le Guenno, G.1    Mahr, A.2    Pagnoux, C.3
  • 16
    • 74849100964 scopus 로고    scopus 로고
    • Incidence and prevention of bladder toxicity from cyclophosphamide in the treatment of rheumatic diseases: A datadriven review
    • Monach PA, Arnold LM, Merkel PA. Incidence and prevention of bladder toxicity from cyclophosphamide in the treatment of rheumatic diseases: a datadriven review. Arthritis Rheum. 2010;62:9-21.
    • (2010) Arthritis Rheum. , vol.62 , pp. 9-21
    • Monach, P.A.1    Arnold, L.M.2    Merkel, P.A.3
  • 17
    • 0026564405 scopus 로고
    • The treatment of Wegener's granulomatosis with glucocorticoids and methotrexate
    • Hoffman GS, Leavitt RY, Kerr GS, et al. The treatment of Wegener's granulomatosis with glucocorticoids and methotrexate. Arthritis Rheum. 1992;35:6112-8.
    • (1992) Arthritis Rheum. , vol.35 , pp. 6112-6118
    • Hoffman, G.S.1    Leavitt, R.Y.2    Kerr, G.S.3
  • 18
    • 0028969403 scopus 로고
    • Analysis of 42 Wegener's granulomatosis patients treated with methotrexate and prednisone
    • Sneller M, Hoffman G, Talar-Williams C, et al. Analysis of 42 Wegener's granulomatosis patients treated with methotrexate and prednisone. Arthritis Rheum. 1995;38:608-13.
    • (1995) Arthritis Rheum. , vol.38 , pp. 608-613
    • Sneller, M.1    Hoffman, G.2    Talar-Williams, C.3
  • 19
    • 0030464106 scopus 로고    scopus 로고
    • Therapy for the maintenance of remission in sixty-five patients with generalized Wegener's granulomatosis. Methotrexate versus trimethoprim/ sulfamethoxazole
    • de Groot K, Reinhold-Keller E, Tatsis E, et al. Therapy for the maintenance of remission in sixty-five patients with generalized Wegener's granulomatosis. Methotrexate versus trimethoprim/sulfamethoxazole. Arthritis Rheum. 1996;39:2052-61.
    • (1996) Arthritis Rheum. , vol.39 , pp. 2052-2061
    • De Groot, K.1    Reinhold-Keller, E.2    Tatsis, E.3
  • 20
    • 0033869129 scopus 로고    scopus 로고
    • Use of methotrexate and glucocorticoids in the treatment of Wegener's granulomatosis. Long-term renal outcome in patients with glomerulonephritis
    • Langford CA, Talar-Williams C, Sneller MC Use of methotrexate and glucocorticoids in the treatment of Wegener's granulomatosis. Long-term renal outcome in patients with glomerulonephritis. Arthritis Rheum. 2000;43:1836-40.
    • (2000) Arthritis Rheum. , vol.43 , pp. 1836-1840
    • Langford, C.A.1    Talar-Williams, C.2    Sneller, M.C.3
  • 21
    • 34548681195 scopus 로고    scopus 로고
    • Substitution of methotrexate for cyclophosphamide in Wegener granulomatosis: A 12-year single-practice experience
    • DOI 10.1097/MD.0b013e3181568ec0, PII 0000579220070900000002
    • Villa-Forte A, Clark TM, Gomes M, et al. Substitution of methotrexate for cyclophosphamide in Wegener granulomatosis: a 12-year single-practice experience. Medicine (Baltimore). 2007;86:269-77. (Pubitemid 47415005)
    • (2007) Medicine , vol.86 , Issue.5 , pp. 269-277
    • Villa-Forte, A.1    Clark, T.M.2    Gomes, M.3    Carey, J.4    Mascha, E.5    Karafa, M.T.6    Roberson, G.7    Langford, C.A.8    Hoffman, G.S.9
  • 22
    • 0037447483 scopus 로고    scopus 로고
    • Use of a cyclophosphamide-induction methotrexate-maintenance regimen for the treatment of Wegener's granulomatosis: Extended follow-up and rate of relapse
    • DOI 10.1016/S0002-9343(03)00077-9
    • Langford CA, Talar-Williams C, Barron KS, et al. Use of a cyclophosphamide-induction methotrexatemaintenance regimen for the treatment of Wegener's granulomatosis: extended follow-up and rate of relapse. Am J Med. 2003;114:463-9. (Pubitemid 36515108)
    • (2003) American Journal of Medicine , vol.114 , Issue.6 , pp. 463-469
    • Langford, C.A.1    Talar-Williams, C.2    Barron, K.S.3    Sneller, M.C.4
  • 23
    • 58149180323 scopus 로고    scopus 로고
    • Azathioprine or methotrexate maintenance for ANCA-associated vasculitis
    • Pagnoux C, Mahr A, Hamidou MA, et al. Azathioprine or methotrexate maintenance for ANCA-associated vasculitis. N Engl J Med. 2008;359:2790-803.
    • (2008) N Engl J Med. , vol.359 , pp. 2790-2803
    • Pagnoux, C.1    Mahr, A.2    Hamidou, M.A.3
  • 24
    • 76649119089 scopus 로고    scopus 로고
    • Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis
    • Tukova J, Chladek J, Nemcova D, et al. Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis. Clin Exp Rheumatol. 2009;27:1047-53.
    • (2009) Clin Exp Rheumatol. , vol.27 , pp. 1047-1053
    • Tukova, J.1    Chladek, J.2    Nemcova, D.3
  • 26
    • 1842628929 scopus 로고    scopus 로고
    • Mycophenolate mofetil for remission maintenance in the treatment of Wegener's granulomatosis
    • Langford CA, Talar-Williams C, Sneller MC. Mycophenolate mofetil for remission maintenance in the treatment of Wegener's granulomatosis. Arthritis Rheum. 2004;51:278-83. (Pubitemid 38468715)
    • (2004) Arthritis Care and Research , vol.51 , Issue.2 , pp. 278-283
    • Langford, C.A.1    Talar-Williams, C.2    Sneller, M.C.3
  • 28
    • 77749277070 scopus 로고    scopus 로고
    • Mycophenolate mofetil for induction and maintenance of remission in microscopic polyangiitis with mild to moderate renal involvement - A prospective, open-label pilot trial
    • Silva F, Specks U, Kalra S, et al. Mycophenolate mofetil for induction and maintenance of remission in microscopic polyangiitis with mild to moderate renal involvement-a prospective, open-label pilot trial. Clin J Am Soc Nephrol. 2010;5:445-53.
    • (2010) Clin J Am Soc Nephrol. , vol.5 , pp. 445-453
    • Silva, F.1    Specks, U.2    Kalra, S.3
  • 29
    • 0035674612 scopus 로고    scopus 로고
    • Response of Wegener's granulomatosis to anti-CD20 chimeric monoclonal antibody therapy
    • DOI 10.1002/1529-0131(200112)44:12<2836::AID-ART471>3.0.CO;2-W
    • Specks U, Fervenza FC, McDonald TJ, et al. Response of Wegener's granulomatosis to anti-CD20 chimeric monoclonal antibody therapy. Arthritis Rheum. 2001;44:2836-40. (Pubitemid 34016203)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.12 , pp. 2836-2840
    • Specks, U.1    Fervenza, F.C.2    McDonald, T.J.3    Hogan, M.C.E.4
  • 30
    • 12344330217 scopus 로고    scopus 로고
    • Induction of remission by B lymphocyte depletion in eleven patients with refractory antineutrophil cytoplasmic antibody-associated vasculitis
    • DOI 10.1002/art.20718
    • Keogh KA, Wylam ME, Stone JH, et al. Induction of remission by B lymphocyte depletion in eleven patients with refractory antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2005;52:262-8. (Pubitemid 40129256)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.1 , pp. 262-268
    • Keogh, K.A.1    Wylam, M.E.2    Stone, J.H.3    Specks, U.4
  • 32
    • 79951518112 scopus 로고    scopus 로고
    • Long-term patient survival in ANCA-associated vasculitis
    • Flossmann O, Berden A, de Groot K, et al. Long-term patient survival in ANCA-associated vasculitis. Ann Rheum Dis. 2011;70:488-94.
    • (2011) Ann Rheum Dis. , vol.70 , pp. 488-494
    • Flossmann, O.1    Berden, A.2    De Groot, K.3
  • 33
    • 67650094918 scopus 로고    scopus 로고
    • A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis
    • Jones RB, Ferraro AJ, Chaudhry AN, et al. A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2009;60:2156-68.
    • (2009) Arthritis Rheum. , vol.60 , pp. 2156-2168
    • Jones, R.B.1    Ferraro, A.J.2    Chaudhry, A.N.3
  • 34
    • 66049135104 scopus 로고    scopus 로고
    • Rituximab is effective in the treatment of refractory ophthalmic Wegener's granulomatosis
    • Taylor SR, Salama AD, Joshi L, et al. Rituximab is effective in the treatment of refractory ophthalmic Wegener's granulomatosis. Arthritis Rheum. 2009;60:1540-7.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1540-1547
    • Taylor, S.R.1    Salama, A.D.2    Joshi, L.3
  • 35
    • 34247486954 scopus 로고    scopus 로고
    • Adjunction of rituximab to steroids and immunosuppressants for refractory/relapsing Wegener's granulomatosis: A study on 8 patients
    • Brihaye B, Aouba A, Pagnoux C, et al. Adjunction of rituximab to steroids and immunosuppressants for refractory/relapsing Wegener's granulomatosis: a study on 8 patients. Clin Exp Rheumatol. 2007;25:S23-7. (Pubitemid 46656590)
    • (2007) Clinical and Experimental Rheumatology , vol.25 , Issue.1 SUPPL. 44
    • Brihaye, B.1    Aouba, A.2    Pagnoux, C.3    Cohen, P.4    Lacassin, F.5    Guillevin, L.6
  • 36
    • 0021960964 scopus 로고
    • Wegener's granulomatosis: Observations on treatment with antimicrobial agents
    • DeRemee RA, McDonald TJ, Weiland LH. Wegener's granulomatosis: observations on treatment with antimicrobial agents. Mayo Clin Proc. 1985;60:27-32. (Pubitemid 15199622)
    • (1985) Mayo Clinic Proceedings , vol.60 , Issue.1 , pp. 27-32
    • DeRemee, R.A.1    McDonald, T.J.2    Weiland, L.H.3
  • 37
    • 0029946561 scopus 로고    scopus 로고
    • Trimethoprim-sulfamethoxazole (Co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis
    • DOI 10.1056/NEJM199607043350103
    • Stegeman CA, Cohen Tervaert JW, de Jong PE, et al. Trimethoprim- sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis. N Engl J Med. 1996;335:16-20. (Pubitemid 26230808)
    • (1996) New England Journal of Medicine , vol.335 , Issue.1 , pp. 16-20
    • Stegeman, C.A.1    Tervaert, J.W.C.2    De Jong, P.E.3    Kallenberg, C.G.M.4
  • 38
    • 0028969403 scopus 로고
    • An analysis of forty-two Wegener's granulomatosis patients treated with methotrexate and prednisone
    • Sneller MC, Hoffman GS, Talar-Williams C, et al. An analysis of forty-two Wegener's granulomatosis patients treated with methotrexate and prednisone. Arthritis Rheum. 1995;38:608-13.
    • (1995) Arthritis Rheum. , vol.38 , pp. 608-613
    • Sneller, M.C.1    Hoffman, G.S.2    Talar-Williams, C.3
  • 39
    • 0028939992 scopus 로고
    • Pneumocystis carinii pneumonia: A major complication of immunosuppressive therapy in patients with Wegener's granulomatosis
    • Ognibene FP, Shelhamer JH, Hoffman GS, et al. Pneumocystis carinii pneumonia: a major complication of immunosuppressive therapy in patients with Wegener's granulomatosis. Am J Respir Crit Care Med. 1995;151:795-9.
    • (1995) Am J Respir Crit Care Med. , vol.151 , pp. 795-799
    • Ognibene, F.P.1    Shelhamer, J.H.2    Hoffman, G.S.3
  • 42
    • 0038752776 scopus 로고    scopus 로고
    • Treatment of subglottic stenosis, due to Wegener's granulomatosis, with intralesional corticosteroids and dilation
    • Hoffman GS, Thomas-Golbanov CK, Chan J, et al. Treatment of subglottic stenosis, due to Wegener's granulomatosis, with intralesional corticosteroids and dilation. J Rheumatol. 2003;30:1017-21. (Pubitemid 36529623)
    • (2003) Journal of Rheumatology , vol.30 , Issue.5 , pp. 1017-1021
    • Hoffman, G.S.1    Thomas-Golbanov, C.K.2    Chan, J.3    Akst, L.M.4    Eliachar, I.5
  • 43
    • 78649676691 scopus 로고    scopus 로고
    • Intralesional corticosteroid injection and dilatation provides effective management of subglottic stenosis in Wegener's granulomatosis
    • Wolter NE, Ooi EH, Witterick IJ. Intralesional corticosteroid injection and dilatation provides effective management of subglottic stenosis in Wegener's granulomatosis. Laryngoscope. 2010;120:2452-5.
    • (2010) Laryngoscope. , vol.120 , pp. 2452-2455
    • Wolter, N.E.1    Ooi, E.H.2    Witterick, I.J.3
  • 44
    • 79952928275 scopus 로고    scopus 로고
    • Plasma exchange for renal vasculitis and idiopathic rapidly progressive glomerulonephritis: A meta-analysis
    • Walsh M, Catapano F, Szpirt W, et al. Plasma exchange for renal vasculitis and idiopathic rapidly progressive glomerulonephritis: a meta-analysis. Am J Kidney Dis. 2011;57:566-74.
    • (2011) Am J Kidney Dis. , vol.57 , pp. 566-574
    • Walsh, M.1    Catapano, F.2    Szpirt, W.3
  • 45
    • 78650476259 scopus 로고    scopus 로고
    • Plasma exchange in the treatment of Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and renal limited vasculitis
    • Casian A, Jayne D. Plasma exchange in the treatment of Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and renal limited vasculitis. Curr Opin Rheumatol. 2011;23:12-7.
    • (2011) Curr Opin Rheumatol. , vol.23 , pp. 12-17
    • Casian, A.1    Jayne, D.2
  • 47
    • 70350537144 scopus 로고    scopus 로고
    • Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood
    • Cabral DA, Uribe AG, Benseler S, et al. Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood. Arthritis Rheum. 2009;60:3413-24.
    • (2009) Arthritis Rheum. , vol.60 , pp. 3413-3424
    • Cabral, D.A.1    Uribe, A.G.2    Benseler, S.3


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