The effects of supersaturation, temperature, agitation and seed surface area on the secondary nucleation of paracetamol in ethanol solutions

Chemical Engineering Science

Volumn 75, Issue , 2012, Pages 183-197

  Frawley, Patrick J ^a   Mitchell, Niall A ^a   Ó'Ciardhá, Clifford T ^a   Hutton, Kieran W ^a  

^a UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

Crystallisation; Kinetics; Mathematical modelling; Nucleation; Optimisation; Pharmaceuticals

Indexed keywords

AGITATION RATES; ATR FTIR; ATTENUATED TOTAL REFLECTANCE; BATCH EXPERIMENTS; CRYSTAL SURFACES; DESUPERSATURATION; ETHANOL SOLUTIONS; EXPERIMENTAL CONDITIONS; EXPERIMENTAL DATA; EXPERIMENTAL TECHNIQUES; FOCUSED BEAM REFLECTANCE MEASUREMENT; FOURIER TRANSFORM INFRARED; IN-SITU PROCESS; INDUCTION TIME; ISOTHERMAL SEEDED BATCH EXPERIMENTS; MATHEMATICAL MODELLING; MODEL SIMULATION; ONLINE MONITORING; OPTIMISATIONS; PARACETAMOL; POPULATION BALANCE EQUATION; PRIMARY NUCLEATION; SECONDARY NUCLEATION; SEED SURFACES; SEEDING PROCESS; SOLUTE CONCENTRATIONS;

CRYSTAL GROWTH; CRYSTALLIZATION; DRUG PRODUCTS; ENZYME KINETICS; ETHANOL; EXPERIMENTS; ISOTHERMS; KINETICS; METHOD OF MOMENTS; SUPERSATURATION;

NUCLEATION;

EID: 84859493321     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2012.03.041     Document Type: Article

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