The regulatory network menin-microRNA 26a as a possible target for RNA-based therapy of bone diseases

Nucleic Acid Therapeutics

Volumn 22, Issue 2, 2012, Pages 103-108

  Luzi, Ettore ^a   Marini, Francesca ^a   Tognarini, Isabella ^a   Galli, Gianna ^a   Falchetti, Alberto ^a   Brandi, Maria Luisa ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 26A; SMAD1 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MENIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; ADIPOSE TISSUE DERIVED STEM CELL; ARTICLE; BONE DEVELOPMENT; BONE DISEASE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; MEN1 TUMOR SUPPRESSOR GENE; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE; UPREGULATION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; ADIPOSE TISSUE; ALKALINE PHOSPHATASE; ANTIGENS, DIFFERENTIATION; BONE DISEASES; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION; GENE REGULATORY NETWORKS; GENES, REPORTER; HUMANS; LUCIFERASES, RENILLA; MICRORNAS; OSTEOBLASTS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; SMAD1 PROTEIN; STEM CELLS;

EID: 84859493107     PISSN: 21593337     EISSN: None     Source Type: Journal    
DOI: 10.1089/nat.2012.0344     Document Type: Article

References (9)

1. AGARWAL, S.K., et al. (2007). Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia 9, 101-107.
2. BALOGH, K., et al. (2006). Menin and its interacting proteins: elucidation of menin function Trends Endocrinol. Metab. 17, 357-364.
3. CHANDRASEKHARAPPA, S.C., et al. (1997). Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276, 404-407.
4. FLYNT, A.S., and LAI, E.C. (2008). Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat. Rev. Genet. 9, 831-842.
5. JAVED, A., et al. (2008). Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J. Biol. Chem. 283, 8412-8422.
6. LUZI E., et al. (2008). Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor. J. Bone Miner. Res. 23, 287-295.
7. LUZI, E., et al. (2010). Ribozyme-mediated compensatory induction of menin-oncosuppressor function in primary fibroblasts from MEN1 patients. Cancer Gene Ther. 17, 814-825.
8. SAINI, H.K., et al. (2007). Genomic analysis of human micro-RNA transcripts. Proc. Natl. Acad. Sci. U. S. A. 104, 17719-17724.
9. SOWA, H., et al. (2003). Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage. J. Biol. Chem. 278, 21058-21069.