Effect of 18α-glycyrrhizic acid and 18β-glycyrrhizic acid on P-gp function and expression in Caco-2 cells

Zhongguo Zhongyao Zazhi

Volumn 37, Issue 1, 2012, Pages 99-103

  Yan, Miao ^a,b   Li, Lanfang ^a,b   Li, Huande ^a,b   Fang, Pingfei ^a,b   Xu, Ping ^a,b   Zheng, Mei ^c   Xu, Danhua ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c First People's Hospital of Fangchenggang   (China)

Author keywords

18 glycyrrhizic acid; 18 glycyrrhizic acid; Caco 2 cells; P gp

Indexed keywords

18ALPHA GLYCYRRHIZIC ACID; 18BETA GLYCYRRHIZIC ACID; CYTOCHROME P450 3A; GLYCOPROTEIN P; GLYCYRRHIZIC ACID DERIVATIVE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; UNCLASSIFIED DRUG; GLYCYRRHIZIC ACID; HERBACEOUS AGENT;

ARTICLE; CELL STRAIN CACO 2; CONCENTRATION (PARAMETERS); DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; FLOW CYTOMETRY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; STEREOCHEMISTRY; CHEMISTRY; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM;

CACO-2 CELLS; DOWN-REGULATION; DRUGS, CHINESE HERBAL; GENE EXPRESSION; GLYCYRRHIZIC ACID; HUMANS; P-GLYCOPROTEINS;

EID: 84859490070     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20120121     Document Type: Article

References (13)

1. Zou Q, Wei P, Li J, et al. Simultaneous determination of 18alpha- and 18beta-glycyrrhetic acid in human plasma by LC-ESI-MS and its application to pharmacokinetics[J]. Biomed Chromatogr, 2009, 23(1):54.
2. Rossi T, Fano R A, Castelli M, et al. Correlation between high intake of glycyrrhizin and myolysis of the papillary muscles: an experimental in vivo study[J]. Pharmacol Toxicol, 1999, 85(5):221.
3. Lin J H. Drug-drug interaction mediated by inhibition and induction of P-glycoprotein[J]. Adv Drug Deliv Rev, 2003, 55(1):53.
4. Paolini M, Pozzetti L, Sapone A, et al. Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases[J]. Life Sci, 1998, 62(6):571.
5. Pal D, Mitra A K. MDR- and CYP3A4-mediated drug-herbal interactions[J]. Life Sci, 2006, 78(18):2131.
6. Tateishi T, Nakura H, Asoh M, et al. Multiple cytochrome P-450 subfamilies are co-induced with P-glycoprotein by both phenothiazine and 2-acetylaminofluorene in rats[J]. Cancer Lett, 1999, 138(1/2):73.
7. Jette L, Beaulieu E, Leclerc J M, et al. Cyclosporin A treatment induces overexpression of P-glycoprotein in the kidney and other tissues[J]. Am J Physiol, 1996, 270(5 Pt 2):F756.
8. Del Moral R G, Andujar M, Ramirez C, et al. Chronic cyclosporin A nephrotoxicity, P-glycoprotein overexpression, and relationships with intrarenal angiotensin II deposits[J]. Am J Pathol, 1997, 151(6):1705.
9. Egashira M, Kawamata N, Sugimoto K, et al. P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833[J]. Blood, 1999, 93(2):599.