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Volumn 19, Issue 2, 2012, Pages 78-90

A personalized approach to treatment: Use of EGFR tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer in Canada

Author keywords

Canadian situation; EGFR; EGFR TKIS; NSCLC

Indexed keywords

AFATINIB; ANTINEOPLASTIC AGENT; CARBOPLATIN; CARBOTAXEL; CISPLATIN; DACOMITINIB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; GEMCITABINE; NERATINIB; PACLITAXEL; PEMETREXED; PLACEBO; UNCLASSIFIED DRUG;

EID: 84859474917     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: 10.3747/co.19.1018     Document Type: Article
Times cited : (8)

References (55)
  • 1
    • 84858795627 scopus 로고    scopus 로고
    • Canadian Cancer Society's Steering Committee, Toronto, ON: Canadian Cancer Society; 2010
    • Canadian Cancer Society's Steering Committee. Canadian Cancer Statistics 2010. Toronto, ON: Canadian Cancer Society; 2010.
    • (2010) Canadian Cancer Statistics
  • 2
    • 84859457183 scopus 로고    scopus 로고
    • United States, National Institutes of Health, National Cancer Institute (nci). [Web page]. Bethesda, MD: nci; n.d. [Available online at, cited September 12
    • United States, National Institutes of Health, National Cancer Institute (nci). General Information About Non-Small Cell Lung Cancer [Web page]. Bethesda, MD: nci; n.d. [Available online at: http://www.cancer.gov/cancertopics/pdq/treatment/non-small-cell-lung/healthprofessional; cited September 12, 2010].
    • (2010) General Information About Non-Small Cell Lung Cancer
  • 3
    • 36849080232 scopus 로고    scopus 로고
    • Cancer Care Ontario and American Society of Clinical Oncology adjuvant chemotherapy and adjuvant radiation therapy for stages i-iii a resectable non small-cell lung cancer guideline
    • Pisters KM, Evans WK, Azzoli CG, et al. Cancer Care Ontario and American Society of Clinical Oncology adjuvant chemotherapy and adjuvant radiation therapy for stages i-iii a resectable non small-cell lung cancer guideline. J Clin Oncol 2007;25:5506-18.
    • (2007) J Clin Oncol , vol.25 , pp. 5506-5518
    • Pisters, K.M.1    Evans, W.K.2    Azzoli, C.G.3
  • 4
    • 79251643266 scopus 로고    scopus 로고
    • Revolution in lung cancer: New challenges for the surgical pathologist
    • Cagle PT, Allen TC, Dacic S, et al. Revolution in lung cancer: new challenges for the surgical pathologist. Arch Pathol Lab Med 2011;135:110-16.
    • (2011) Arch Pathol Lab Med , vol.135 , pp. 110-116
    • Cagle, P.T.1    Allen, T.C.2    Dacic, S.3
  • 5
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002;346:92-8.
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3
  • 6
    • 79952981004 scopus 로고    scopus 로고
    • Lung cancer and the future of pathology
    • Cagle PT, Dacic S. Lung cancer and the future of pathology. Arch Pathol Lab Med 2011;135:293-5.
    • (2011) Arch Pathol Lab Med , vol.135 , pp. 293-295
    • Cagle, P.T.1    Dacic, S.2
  • 7
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 8
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Jänne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Jänne, P.A.2    Lee, J.C.3
  • 9
    • 4444344330 scopus 로고    scopus 로고
    • Egf receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al. egf receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-11.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 10
    • 43749090705 scopus 로고    scopus 로고
    • EGFR mutations in lung adenocarcinomas: Clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression
    • Li AR, Chitale D, Riely GJ, et al. EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression. J Mol Diagn 2008;10:242-8.
    • (2008) J Mol Diagn , vol.10 , pp. 242-248
    • Li, A.R.1    Chitale, D.2    Riely, G.J.3
  • 11
    • 33947434048 scopus 로고    scopus 로고
    • Which biomarker predicts benefit from egfr-tki treatment for patients with lung cancer?
    • Uramoto H, Mitsudomi T. Which biomarker predicts benefit from egfr-tki treatment for patients with lung cancer? Br J Cancer 2007;96:857-63.
    • (2007) Br J Cancer , vol.96 , pp. 857-863
    • Uramoto, H.1    Mitsudomi, T.2
  • 12
    • 84859470484 scopus 로고    scopus 로고
    • Population-based pan- Canadian EGFR-mutation testing program [abstract e18017]
    • Available online at, cited February 8, 2012
    • Tsao MS, Ionescu G, Chong D, et al. Population-based pan- Canadian EGFR-mutation testing program [abstract e18017]. J Clin Oncol 2011;29:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=102&abstractID=82932; cited February 8, 2012]
    • (2011) J Clin Oncol , pp. 29
    • Tsao, M.S.1    Ionescu, G.2    Chong, D.3
  • 13
    • 66949133946 scopus 로고    scopus 로고
    • Clinical efficacy and toxicity of anti-egfr therapy in common cancers
    • Harandi A, Zaidi AS, Stocker AM, Laber DA. Clinical efficacy and toxicity of anti-egfr therapy in common cancers. J Oncol 2009;2009:567486.
    • (2009) J Oncol , vol.2009 , pp. 567486
    • Harandi, A.1    Zaidi, A.S.2    Stocker, A.M.3    Laber, D.A.4
  • 14
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase ii trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the ideal 1 Trial)
    • Erratum in: J Clin Oncol 2004;22:4811
    • Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase ii trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the ideal 1 Trial). J Clin Oncol 2003;21:2237-46. [Erratum in: J Clin Oncol 2004;22:4811]
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 15
    • 77950577933 scopus 로고    scopus 로고
    • Systemic therapies in metastatic non-small-cell lung cancer with emphasis on targeted therapies: The rational approach
    • Hirsh V. Systemic therapies in metastatic non-small-cell lung cancer with emphasis on targeted therapies: the rational approach. Curr Oncol 2010;17:13-23.
    • (2010) Curr Oncol , vol.17 , pp. 13-23
    • Hirsh, V.1
  • 16
    • 80052651609 scopus 로고    scopus 로고
    • Mechanisms of resistance to egfr tkis and development of a new generation of drugs in non-small-cell lung cancer
    • Kosaka T, Yamaki E, Mogi A, Kuwano H. Mechanisms of resistance to egfr tkis and development of a new generation of drugs in non-small-cell lung cancer. J Biomed Biotechnol 2011;2011:165214.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 165214
    • Kosaka, T.1    Yamaki, E.2    Mogi, A.3    Kuwano, H.4
  • 17
    • 2642539590 scopus 로고    scopus 로고
    • Outcomes of patients with advanced non-small cell lung cancer treated with gefitinib (ZD1839, "Iressa") on an expanded access study
    • Jänne PA, Gurubhagavatula S, Yeap BY, et al. Outcomes of patients with advanced non-small cell lung cancer treated with gefitinib (ZD1839, "Iressa") on an expanded access study. Lung Cancer 2004;44:221-30.
    • (2004) Lung Cancer , vol.44 , pp. 221-230
    • Jänne, P.A.1    Gurubhagavatula, S.2    Yeap, B.Y.3
  • 18
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-32.
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Pereira, J.R.2    Ciuleanu, T.3
  • 19
    • 75249084998 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase ii study of sequential erlotinib and chemotherapy as firstline treatment for advanced non-small-cell lung cancer
    • Mok TS, Wu YL, Yu CJ, et al. Randomized, placebo-controlled, phase ii study of sequential erlotinib and chemotherapy as firstline treatment for advanced non-small-cell lung cancer. J Clin Oncol 2009;27:5080-7.
    • (2009) J Clin Oncol , vol.27 , pp. 5080-5087
    • Mok, T.S.1    Wu, Y.L.2    Yu, C.J.3
  • 20
    • 77952526670 scopus 로고    scopus 로고
    • A small step towards personalized medicine for non-small cell lung cancer
    • Mok T, Wu YL, Zhang L. A small step towards personalized medicine for non-small cell lung cancer. Discov Med 2009;8:227-31.
    • (2009) Discov Med , vol.8 , pp. 227-231
    • Mok, T.1    Wu, Y.L.2    Zhang, L.3
  • 21
    • 65749109060 scopus 로고    scopus 로고
    • The role of the epidermal growth factor receptor tyrosine kinase inhibitors as therapy for advanced, metastatic, and recurrent non-small-cell lung cancer: A Canadian national consensus statement
    • Ellis PM, Morzycki W, Melosky B, et al. The role of the epidermal growth factor receptor tyrosine kinase inhibitors as therapy for advanced, metastatic, and recurrent non-small-cell lung cancer: a Canadian national consensus statement. Curr Oncol 2009;16:27-48.
    • (2009) Curr Oncol , vol.16 , pp. 27-48
    • Ellis, P.M.1    Morzycki, W.2    Melosky, B.3
  • 22
    • 65349167234 scopus 로고    scopus 로고
    • EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to egfr inhibitors
    • Sartori G, Cavazza A, Sgambato A, et al. EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to egfr inhibitors. Am J Clin Pathol 2009;131:478-89.
    • (2009) Am J Clin Pathol , vol.131 , pp. 478-489
    • Sartori, G.1    Cavazza, A.2    Sgambato, A.3
  • 23
    • 58049205542 scopus 로고    scopus 로고
    • Correlation between morphology and EGFR mutations in lung adenocarcinomas. Significance of the micropapillary pattern and the hobnail cell type
    • Ninomiya H, Hiramatsu M, Inamura K, et al. Correlation between morphology and EGFR mutations in lung adenocarcinomas. Significance of the micropapillary pattern and the hobnail cell type. Lung Cancer 2009;63:235-40.
    • (2009) Lung Cancer , vol.63 , pp. 235-240
    • Ninomiya, H.1    Hiramatsu, M.2    Inamura, K.3
  • 24
    • 79957510807 scopus 로고    scopus 로고
    • Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas
    • D'Angelo SP, Pietanza MC, Johnson ML, et al. Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas. J Clin Oncol 2011;29:2066-70.
    • (2011) J Clin Oncol , vol.29 , pp. 2066-2070
    • D'angelo, S.P.1    Pietanza, M.C.2    Johnson, M.L.3
  • 25
    • 84939781286 scopus 로고    scopus 로고
    • Epidermal Growth Factor Receptor (EGFR) Genetic Testing for Prediction of Response to EGFR-Targeted (TKI) Drugs in Patients with Advanced Non-Small-Cell Lung Cancer: An Evidence-Based Analysis
    • Ontario, Ministry of Health and Long-Term Care, Medical Advisory Secretariat (mas), Toronto, ON: mas; 2010, Available online at, cited September
    • Ontario, Ministry of Health and Long-Term Care, Medical Advisory Secretariat (mas). Epidermal Growth Factor Receptor (EGFR) Genetic Testing for Prediction of Response to EGFR-Targeted (TKI) Drugs in Patients with Advanced Non-Small-Cell Lung Cancer: An Evidence-Based Analysis. Ontario health technology assessment series. Vol. 10. Iss. 24. Toronto, ON: mas; 2010. [Available online at: http://www.health.gov.on.ca/english/providers/program/mas/tech/reviews/pdf/EGFR_20101209.pdf; cited September 2011]
    • (2011) Ontario Health Technology Assessment Series , vol.10 , Issue.24
  • 26
    • 79957492069 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non-small-cell lung cancer considering firstline egfr tyrosine kinase inhibitor therapy
    • Keedy VL, Temin S, Somerfield MR, et al. American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non-small-cell lung cancer considering firstline egfr tyrosine kinase inhibitor therapy. J Clin Oncol 2011;29:2121-7.
    • (2011) J Clin Oncol , vol.29 , pp. 2121-2127
    • Keedy, V.L.1    Temin, S.2    Somerfield, M.R.3
  • 28
    • 34548849132 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutation testing in lung cancer: Searching for the ideal method
    • Pao W, Ladanyi M. Epidermal growth factor receptor mutation testing in lung cancer: searching for the ideal method. Clin Cancer Res 2007;13:4954-5.
    • (2007) Clin Cancer Res , vol.13 , pp. 4954-4955
    • Pao, W.1    Ladanyi, M.2
  • 29
    • 84856928052 scopus 로고    scopus 로고
    • The role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of advanced stage non-small cell lung cancer
    • Voon PJ, Chul Cho B, Yeo WL, Soo RA. The role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of advanced stage non-small cell lung cancer. J Thorac Dis 2010;2:144-53.
    • (2010) J Thorac Dis , vol.2 , pp. 144-153
    • Voon, P.J.1    Cho, B.C.2    Yeo, W.L.3    Soo, R.A.4
  • 30
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced nonsmall- cell lung cancer: A phase iii trial-intact 1
    • Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced nonsmall- cell lung cancer: a phase iii trial-intact 1. J Clin Oncol 2004;22:777-84.
    • (2004) J Clin Oncol , vol.22 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 31
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced nonsmall- cell lung cancer: A phase iii trial-intact 2
    • Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced nonsmall- cell lung cancer: a phase iii trial-intact 2. J Clin Oncol 2004;22:785-94.
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 32
    • 24944440830 scopus 로고    scopus 로고
    • Tribute: A phase iii trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst RS, Prager D, Hermann R, et al. tribute: a phase iii trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005;23:5892-9.
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 33
    • 34248140107 scopus 로고    scopus 로고
    • Phase iii study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The Tarceva Lung Cancer Investigation Trial
    • Gatzemeier U, Pluzanska A, Szczesna A, et al. Phase iii study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol 2007;25:1545-52.
    • (2007) J Clin Oncol , vol.25 , pp. 1545-1552
    • Gatzemeier, U.1    Pluzanska, A.2    Szczesna, A.3
  • 34
    • 72449160988 scopus 로고    scopus 로고
    • A randomized phase iii study of gefitinib (Iressa) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung [abstract PRS.4]
    • Lee JS, Park K, SW K, et al. A randomized phase iii study of gefitinib (Iressa) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung [abstract PRS.4]. J Thorac Oncol 2009;4(suppl 1):S283.
    • (2009) J Thorac Oncol , vol.4 , Issue.SUPPL. 1
    • Lee, J.S.1    Park, K.2    Sw, K.3
  • 35
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin- paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin- paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 36
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010;362:2380-8.
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 37
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-8.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 38
    • 79954606282 scopus 로고    scopus 로고
    • Efficacy results from the randomized phase iii optimal (ctonG 0802) study comparing first-line erlotinib versus carboplatin (cbdca) plus gemcitabine (gem), in Chinese advanced nonsmall-cell lung cancer (nsclc) patients (pts) with EGFR activating mutations [abstract LBA13]
    • Zhou C, Wu YL, Chen G, et al. Efficacy results from the randomized phase iii optimal (ctonG 0802) study comparing first-line erlotinib versus carboplatin (cbdca) plus gemcitabine (gem), in Chinese advanced nonsmall-cell lung cancer (nsclc) patients (pts) with EGFR activating mutations [abstract LBA13]. Ann Oncol 2010;21(suppl 8):viii6.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 39
    • 80053561215 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy (ct) in advanced non-small cell lung cancer (nsclc) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (eurtac) phase iii randomized trial [abstract 7503]
    • Available online at, cited February 8, 2012
    • Rosell R, Gervais R, Vergnenegre A et al. Erlotinib versus chemotherapy (ct) in advanced non-small cell lung cancer (nsclc) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (eurtac) phase iii randomized trial [abstract 7503]. J Clin Oncol 2011;29:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=102&abstractID=78285; cited February 8, 2012]
    • (2011) J Clin Oncol , vol.29
    • Rosell, R.1    Gervais, R.2    Vergnenegre, A.3
  • 40
    • 84859461230 scopus 로고    scopus 로고
    • AstraZeneca Canada, Mississauga, ON: AstraZeneca Canada
    • AstraZeneca Canada. IRESSA (Gefitinib Tablets) [product monograph]. Mississauga, ON: AstraZeneca Canada; 2009.
    • (2009) IRESSA (Gefitinib Tablets) [product Monograph]
  • 41
    • 79960460262 scopus 로고    scopus 로고
    • Efficacy and safety of PF299804 as first-line treatment (tx) of patients (pts) with advanced (adv) nsclc selected for activating mutation (mu) of epidermal growth factor receptor (egfr)
    • Mok TSK, Spigel DR, Park K, et al. Efficacy and safety of PF299804 as first-line treatment (tx) of patients (pts) with advanced (adv) nsclc selected for activating mutation (mu) of epidermal growth factor receptor (egfr). Ann Oncol 2010;21(suppl 8):viii1-12.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Mok, T.S.K.1    Spigel, D.R.2    Park, K.3
  • 42
    • 84859452715 scopus 로고    scopus 로고
    • A phase ii study of BIBW 2992 in patients with adenocarcinoma of the lung and activating egfr/ her1 mutations (LUX-Lung 2) [abstract 7521]
    • Available online at, cited February 8
    • Yang C, Shih J, Su W, et al. A phase ii study of BIBW 2992 in patients with adenocarcinoma of the lung and activating egfr/ her1 mutations (LUX-Lung 2) [abstract 7521]. J Clin Oncol 2010;28:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=74&abstractID=50532; cited February 8, 2012]
    • (2010) J Clin Oncol , vol.28
    • Yang, C.1    Shih, J.2    Su, W.3
  • 43
    • 0034069620 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinumbased chemotherapy
    • Shepherd FA, Dancey J, Ramlau R, et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinumbased chemotherapy. J Clin Oncol 2000;18:2095-103.
    • (2000) J Clin Oncol , vol.18 , pp. 2095-2103
    • Shepherd, F.A.1    Dancey, J.2    Ramlau, R.3
  • 44
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase iii trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • Hanna N, Shepherd FA, Fossella FV, et al. Randomized phase iii trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004;22:1589-97.
    • (2004) J Clin Oncol , vol.22 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3
  • 45
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (interest): A randomised phase iii trial
    • Kim ES, Hirsh V, Mok T, et al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (interest): a randomised phase iii trial. Lancet 2008;372:1809-18.
    • (2008) Lancet , vol.372 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3
  • 46
    • 52049125250 scopus 로고    scopus 로고
    • Phase iii study, V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer
    • Maruyama R, Nishiwaki Y, Tamura T, et al. Phase iii study, V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer. J Clin Oncol 2008;26:4244-52.
    • (2008) J Clin Oncol , vol.26 , pp. 4244-4252
    • Maruyama, R.1    Nishiwaki, Y.2    Tamura, T.3
  • 47
    • 76749154617 scopus 로고    scopus 로고
    • Randomized phase iii trial of gefitinib versus docetaxel in non-small cell lung cancer patients who have previously received platinum-based chemotherapy
    • Lee DH, Park K, Kim JH, et al. Randomized phase iii trial of gefitinib versus docetaxel in non-small cell lung cancer patients who have previously received platinum-based chemotherapy. Clin Cancer Res 2010;16:1307-14.
    • (2010) Clin Cancer Res , vol.16 , pp. 1307-1314
    • Lee, D.H.1    Park, K.2    Kim, J.H.3
  • 48
    • 84856908818 scopus 로고    scopus 로고
    • Pemetrexed (mta) compared with erlotinib (erl) in pretreated patients with advanced non-small cell lung cancer (nsclc): Results of a randomized phase iii Hellenic Oncology Research Group trial [abstract 7519]
    • Available online at, cited February 8
    • Vamvakas L, Agelaki S, Kentepozidis NK, et al. Pemetrexed (mta) compared with erlotinib (erl) in pretreated patients with advanced non-small cell lung cancer (nsclc): results of a randomized phase iii Hellenic Oncology Research Group trial [abstract 7519]. J Clin Oncol 2010;28:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=74&abstractID=43881; cited February 8, 2012]
    • (2010) J Clin Oncol , vol.28
    • Vamvakas, L.1    Agelaki, S.2    Kentepozidis, N.K.3
  • 49
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527-37.
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 50
    • 84859448272 scopus 로고    scopus 로고
    • Symptom and health-related quality of life benefit of afatinib (BIBW 2992) in advanced nsclc patients previously treated with erlotinib or gefitinib: Results of a randomized phase iii trial (LUX-Lung 1) [abstract 011.07]
    • Hirsh V, Cadranel J, Cong J, et al. Symptom and health-related quality of life benefit of afatinib (BIBW 2992) in advanced nsclc patients previously treated with erlotinib or gefitinib: results of a randomized phase iii trial (LUX-Lung 1) [abstract 011.07]. J Thorac Oncol 2011;6(suppl 2):S324.
    • (2011) J Thorac Oncol , vol.6 , Issue.SUPPL. 2
    • Hirsh, V.1    Cadranel, J.2    Cong, J.3
  • 51
    • 84857910650 scopus 로고    scopus 로고
    • Subgroup analysis of LUX-Lung 1: A randomized phase iii trial of afatinib (BIBW 2992) + best supportive care (bsc) versus placebo + bsc in patients failing 1-2 lines of chemotherapy and erlotinib or gefitinib [abstract LBPL3]
    • Miller VA, Hirsh V, Cadranal J, et al. Subgroup analysis of LUX-Lung 1: a randomized phase iii trial of afatinib (BIBW 2992) + best supportive care (bsc) versus placebo + bsc in patients failing 1-2 lines of chemotherapy and erlotinib or gefitinib [abstract LBPL3]. J Thorac Oncol 2010;5 (suppl 7):S557.
    • (2010) J Thorac Oncol , vol.5 , Issue.SUPPL. 7
    • Miller, V.A.1    Hirsh, V.2    Cadranal, J.3
  • 52
    • 79959299592 scopus 로고    scopus 로고
    • An Irreversible Human Epidermal Growth Factor Receptor (egfr) Inhibitor, Versus (v) Erlotinib (e) In Patients (pts) With Advanced Non-small Cell Lung Cancer (nsclc) After Chemotherapy (ct) Failure: Quantitative and Qualitative Benefits [abstract 365PD]
    • Randomized Phase 2 Study of PF299804
    • Ramalingam SS, Boyer MJ, Park K, et al. Randomized phase 2 study of PF299804, an irreversible human epidermal growth factor receptor (egfr) inhibitor, versus (v) erlotinib (e) in patients (pts) with advanced non-small cell lung cancer (nsclc) after chemotherapy (ct) failure: quantitative and qualitative benefits [abstract 365PD]. Ann Oncol 2010;21(suppl 8):viii122.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Ramalingam, S.S.1    Boyer, M.J.2    Park, K.3
  • 53
    • 71649091295 scopus 로고    scopus 로고
    • Efficacy and safety of PF-00299804 (PF299) in patients (pt) with advanced nsclc after failure of at least one prior chemotherapy regimen and prior treatment with erlotinib (e): A two-arm, phase ii trial [abstract 8063]
    • Available online at, cited February 8, 2012
    • Janne PA, Reckamp K, Koczywas M, et al. Efficacy and safety of PF-00299804 (PF299) in patients (pt) with advanced nsclc after failure of at least one prior chemotherapy regimen and prior treatment with erlotinib (e): a two-arm, phase ii trial [abstract 8063]. J Clin Oncol 2009;27:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=32872; cited February 8, 2012]
    • (2009) J Clin Oncol , vol.27
    • Janne, P.A.1    Reckamp, K.2    Koczywas, M.3
  • 55
    • 79959295780 scopus 로고    scopus 로고
    • Managing treatment-related adverse events associated with egfr tyrosine kinase inhibitors in advanced non-small-cell lung cancer
    • Hirsh V. Managing treatment-related adverse events associated with egfr tyrosine kinase inhibitors in advanced non-small-cell lung cancer. Curr Oncol 2011;18:126-38.
    • (2011) Curr Oncol , vol.18 , pp. 126-138
    • Hirsh, V.1


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