N-acetylcysteine prevents pulmonary edema and acute kidney injury in rats with sepsis submitted to mechanical ventilation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 7, 2012, Pages

  Campos, Renata ^a   Shimizu, Maria Heloísa Massola ^a   Volpini, Rildo Aparecido ^a   de Bragança, Ana Carolina ^a   Andrade, Lucia ^a   dos Santos Lopes, Fernanda Degobbi Tenório Quirino ^a   Olivo, Clarice ^a   Canale, Daniele ^a   Seguro, Antonio Carlos ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute renal injury; Cecal ligation and puncture; Oxidative stress; Respiratory mechanics

Indexed keywords

8 ISOPROSTANE; ACETYLCYSTEINE; DRINKING WATER; EPITHELIAL SODIUM CHANNEL; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRY WEIGHT; EXPERIMENTAL LIGATION; GLOMERULUS FILTRATION RATE; KIDNEY FUNCTION; LUNG EDEMA; LUNG FUNCTION; LUNG MECHANICS; LUNG WEIGHT; MALE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEPSIS; SURVIVAL RATE; TIDAL VOLUME; UPREGULATION;

ACETYLCYSTEINE; ACUTE KIDNEY INJURY; ANIMALS; ANTIOXIDANTS; CECUM; DISEASE MODELS, ANIMAL; GLOMERULAR FILTRATION RATE; KIDNEY; LUNG; MALE; NEUTROPHILS; OXIDATIVE STRESS; PULMONARY EDEMA; RATS; RATS, WISTAR; RESPIRATION, ARTIFICIAL; SEPSIS; SODIUM CHANNELS; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

EID: 84859470521     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00097.2011     Document Type: Article

References (43)

1. Andrade L, Rodrigues AC Jr, Sanches TR, Souza RB, Seguro AC. Leptospirosis leads to dysregulation of sodium transporters in kidney and lung. Am J Physiol Renal Physiol 292: F586-F592, 2007.
2. Andrades M, Ritter C, de Oliveira MR. Antioxidant treatment reverses organ failure in rat model of sepsis: role of antioxidant enzymes imbalance, neutrophil infiltration and oxidative stress. J Surg Res 15: 307-313, 2011.
3. Bates JHT. Pulmonary mechanics: a system identification perspective. In: 31st Annual International Conference of the IEEE EMBS. Minneapolis, MN, September 2-6, 2009.
4. Carpenter TC, Stenmark KR. Endothelin receptor blockade decreases lung water in young rats exposed to viral infection and hypoxia. Am J Physiol Lung Cell Mol Physiol 279: L547-L554, 2000.
5. De Araujo M, Andrade L, Coimbra TM, Rodrigues AC Jr, Seguro AC. Magnesium supplementation combined with N-acetylcysteine protects against postischemic acute renal failure. J Am Soc Nephrol 16: 3339-3349, 2005.
6. Dehne MG, Meister M, Röhrig R, Katzer C, Mann V. Effects of inverse ratio ventilation with PEEP on kidney function. Ren Fail 32: 411-416, 2010.
7. _channel (EnaC) mRNA level and activity. Pediatr Res 48: 304-310, 2000.
8. Doi K, Leelahavanichkul A, Yen STP, Star RA. Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest 119: 2868-2878, 2009.
9. Durand T, Bultel-Poncé V, Guy A, El Fangour S, Rossi JC, Galano JM. Isoprostanes and phytoprostanes bioactive lipids. Biochimie 93: 52-60, 2011.
10. Gürer A, Ozdoǧan M, Gökakin AK, Gömceli I, Gülbahar O, Arikök AT, Kulaçoǧlu H, Aydin R. Tissue oxidative stress level and remote organ injury in two-hit trauma model of sequential burn injury and peritoneal sepsis are attenuated with N-acetylcysteine treatment in rats. Ulus Travma Acil Cerrahi Derg 15: 1-6, 2009.
11. Kao SJ, Wang D, Lin HI, Chen H. N-acetylcysteine abrogates acute lung injury induced by endotoxin. Clin Exp Pharmacol Physiol 33: 33-40, 2006.
12. Kuiper JW, Groeneveld AB, Slutsky AS, Plotz FB. Mechanical ventilation and acute renal failure. Crit Care Med 33: 1408-1415, 2005.
13. Lanças T, Kasahara DI, Gross JF, Pires-Neto RC, Deheinzelin D, Mauad T, Negri EM, Dolhnikoff M. Cholinergic hyperresponsiveness of peripheral lung parenchyma in chronic obstructive pulmonary disease. Respiration 82: 177-184, 2011.
14. Leff JA, Wilke CP, Hybertrson BM, Shanley PF, Beehler CJ, Repine JE. Postinsult treatment with N-acetyl-L-cysteine decreases IL-1 induced neutrophil influx and lung leak in rats. Am J Physiol Lung Cell Mol Physiol 265: L501-L506, 1993.
15. Li X, Hassoun HT, Santora R, Rabb H. Organ crosstalk: the role of the kidney. Curr Opin Crit Care 15: 481-487, 2009.
16. Luque A, Shimizu MH, Andrade L, Sanches TR, Seguro AC. Glomerular infiltration is reduced by high tidal volume ventilation is a vivo healthy rat model. Braz J Med Biol Res 42: 1104-1109, 2009.
17. Martin GS, Bernard GR. Airway and lung in sepsis. Intensive Care Med 27: S63-S79, 2001.
18. Matthay MA. Alveolar fluid clearance in patients with ARDS: does it make a difference? Chest 122, Suppl 6: 340S-343S, 2002.
19. Matthay MA, Su X. Pulmonary barriers to pneumonia and sepsis. Nat Med 13: 780-781, 2007.
20. Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA Jr, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med 167: 1027-1035, 2003.
21. Miyaji T, Hu X, Yuen PS, Muramatsu Y, Iyer S, Hewitt SM, Star RA. Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int 64: 1620-1631, 2003.
22. Modelska K, Matthay MA, Brown LA, Deutch E, Lu LN, Pittet JF. Inhibition of-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock. Am J Physiol Lung Cell Mol Physiol 276: L844-L857, 1999.
23. Molitoris BA. Renal blood flow in sepsis. A complex issue. Crit Care 9: 327-328, 2005.
24. Nguyen MT, Pace AJ, Koller BH. Mice lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia. J Exp Med 204: 1383-1393, 2007.
25. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem 95: 351-358, 1979.
26. Ozdulger A, Cinel I, Koksel O. The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture induced sepsis model. Shock 19: 366-372, 2003.
27. Parker JC, Townsley MI. Evaluation of lung injury in rats and mice. Am J Physiol Lung Cell Mol Physiol 286: L231-L246, 2004.
28. Rabb H, Wang Z, Nemoto T, Hotchkiss J, Yokota N, Soleimani M. Acute renal failure leads a dysregulation of salt and water channels. Kidney Int 63: 600-606, 2004.
29. Ricci Z, Ronco C. Pulmonary/renal interaction. Curr Opin Crit Care 16: 13-18, 2010.
30. Ritter C, Andrades ME, Reinke A, Menna-Barreto S, Moreira JC, Dal-Pizzol F. Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis. Crit Care Med 32: 342-349, 2004.
31. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group. Early goal directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345: 1368-1377, 2001.
32. Rodriguez ZZ, Guanche D, Álvarez RG, Rosales FH, Alonso Y, Schulz S. Preconditioning with ozone/oxygen misture induces reversion of some indicators of oxidative stress and prevents organic damage in rats with fecal peritonitis. Inflamm Res 58: 371-375, 2009.
33. Sartori C, Matthay MA. Alveolar epithelial fluid transport in acute lung injury: new insights. Eur Respir J 20: 1299-1313, 2002.
34. Shimizu MH, Danilovic A, Andrade L, Volpini RA, Libório AB, Sanches TR, Seguro AC. N-acetylcysteine protects against renal injury following bilateral ureteral obstruction. Nephrol Dial Transplant 23: 3067-3073, 2008.
35. Spapen H, Zhang H, Demanet C, Vleminckx W, Vincent JL, Huyghens L. Does N-acetyl-L-cysteine influence cytokine response during early human septic shock? Chest 113: 1616-1624, 1998.
36. Tsimikas S. In vivo markers of oxidative stress and therapeutic interventions. Am J Cardiol 101: 34D-42D, 2008.
37. Vieira RP, Duarte ACS, Claudino RC, Perini A, Santos AB, Moriya HT, Arantes-Costa FM, Martins MA, Carvalho CR, Dolhnikoff M. Creatine supplementation exacerbates allergic lung inflamation and airway remodeling in mice. Am J Respir Cell Mol Biol 37: 660-667, 2007.
38. Volpini RA, Costa RS, da Silva CG, Coimbra TM. Inhibition of nuclear factor B activation attenuates tubulointersticial nephrits induced by gentamicin. Nephron Physiol 98: 97-106, 2004.
39. Wan L, Bagshaw SM, Langenberg C, Saotome T, May C, Bellomo R. Pathophysiology of septic acute kidney injury: what do we really know? Crit Care Med 36: S198-S203, 2008.
40. Ware IB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 163: 1376-1383, 2001.
41. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med 340:207-214, 1999.
42. Zafarullah M, Li WQ, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60: 6-20, 2003.
43. Zhang H, Slutsky AS, Vincent JL. Oxygen free radicals in ARDS, septic shock and organ dysfunction. Intensive Care Med 26: 474-476, 2000.