Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 13, 2012, Pages 4869-4874

  Bakker, Gert Jan ^a   Eich, Christina ^b   Torreno Pina, Juan A ^c   Diez Ahedo, Ruth ^a   Perez Samper, Gemma ^a   Van Zanten, Thomas S ^c   Figdor, Carl G ^b   Cambi, Alessandra ^b   Garcia Parajo, Maria F ^c,d  

^a BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ICFO INSTITUT DE CIENCIES FOTONIQUES   (Spain)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Cumulative probability distribution; Integrin lymphocyte function associated antigen 1; Intercellular adhesion molecule; Single molecule detection

Indexed keywords

CALCIUM ION; INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ANALYTIC METHOD; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; LEUKOCYTE ADHERENCE; LIGAND BINDING; LIPID RAFT; MONOCYTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHEAR FLOW; SINGLE DYE TRACKING;

ACTIN CYTOSKELETON; CALCIUM; CELL ADHESION; CELL LINE; CELL MOVEMENT; CLUSTER ANALYSIS; DIFFUSION; EXTRACELLULAR SPACE; HUMANS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MONOCYTES; NANOPARTICLES; PROTEIN TRANSPORT; RHEOLOGY; STRESS, MECHANICAL;

EID: 84859463286     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116425109     Document Type: Article

References (35)

1. Takagi J, et al. (2002) Global conformational rearrangements inintegrin extracellular domains in outside-in and inside-out signaling. Cell 110:599-611. (Pubitemid 35247840)
2. Luo BH, Carman CV, Springer TA (2007) Structural basis of integrin regulation and signaling. Annu Rev Immunol 25:619-647. (Pubitemid 46697919)
3. Takagi J, Springer TA (2002) Integrin activation and structural rearrangement. Immunol Rev 186:141-163.
4. van Kooyk Y, van Vliet SJ, Figdor CG (1999) The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes. J Biol Chem 274:26869-26877.
5. Katagiri K, et al. (2003) RAPL, aRap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol 4:741-748. (Pubitemid 36986757)
6. Dustin ML, Bivona TG, Philips MR (2004) Membranes as messengers in T cell adhesion signaling. Nat Immunol 5:363-372. (Pubitemid 38500084)
7. Shimaoka M, et al. (2003) Structures of the alpha LI domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 112:99-111. (Pubitemid 36106422)
8. Carman CV, Springer TA (2003) Integrin avidity regulation: Are changes in affinity and conformation underemphasized? Opin Cell Biol 15:547-556. (Pubitemid 37176963)
9. Ward MD, Dembo M, Hammer DA (1994) Kinetics of cell detachment: peeling of discrete receptor clusters. Biophys J 67:2522-2534. (Pubitemid 24369677)
10. Chen A, Moy VT (2000) Cross-linking of cell surface receptors enhances cooperativity of molecular adhesion. Biophys J 78:2814-1820.
11. Selhuber-Unkel C, et al. (2008) Cooperativity in adhesion cluster formation during initial cell adhesion. Biophys J 95:5424-5431.
12. Kucik DF, et al. (1996) Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes. J Clin Invest 97:2139-2144. (Pubitemid 26143969)
13. 2+-dependent protease, calpain. J Cell Biol 140:699-707.
14. Sigal A, et al. (2000) The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment. J Immunol 165:442-452. (Pubitemid 30429538)
15. Jin T, Li J (2002) Dynamitin controls 2integrin avidity by modulating cytoskeletal constraint on integrin molecules. J Biol Chem 277:32963-32969. (Pubitemid 34984810)
16. 2integrin avidity. J Biol Chem 276:44762-44769.
17. van Kooyk Y, et al. (1989) Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature 342:811-813.
18. Dustin ML, Springer TA (1989) T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341:619-624. (Pubitemid 19257309)
19. Marlin SD, Springer TA (1987) Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 51:813-819.
20. Cambi A, et al. (2006) Organization of the integrin LFA-1 in nanoclusters regulates its activity. Mol Biol Cell 17:4270-4281. (Pubitemid 44522048)
21. van Zanten TS, et al. (2009) Hotspots of GPI-anchored proteins and integrin nano-clusters function as nucleation sites for cell adhesion. Proc Natl Acad Sci USA 106:18557-18562.
22. van Zanten TS, et al. (2010) Direct mapping of nanoscale compositional connectivity on intact cell membranes. Proc Natl Acad Sci USA 107:15437-15442.
23. Diez-Ahedo R, et al. (2009) Dynamic re-organization of individual adhesion nanoclusters in living cells by ligand-patterned surfaces. Small 5:1258-1263.
24. Shulman Z, et al. (2009) Lymphocyte crawling onand through activated endothelium is mediated by millipede-like contacts generated by chemokine triggered high affinity LFA-1 primed by shear forces. Immunity 30:384-396.
25. Schütz GJ, Schindler H, Schmidt T (1997) Single molecule microscopy in model membranes reveals anomalous diffusion. Biophys J 73:1073-1080. (Pubitemid 27337641)
26. Keizer GD, et al. (1988) A monoclonal antibody (NKI-L16) directed against a unique epitope on the alpha-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions. J Immunol 140:1393-1400.
27. 2+-dependent epitope in the thigh/genu interface upon activation. Proc Natl Acad Sci USA 101:15422-15427.
28. Chen JF, Salas A, Springer TA (2003) Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster. Nature Struct Biol 10:995-1001. (Pubitemid 37500491)
29. Andrew D, et al. (1993) KIM185, amonoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA-1- and CR3-dependent adhesion. Eur J Immunol 23:2217-2222. (Pubitemid 23265885)
30. Lub M, et al. (1997) Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1. Mol Biol Cell 8:341-351. (Pubitemid 27097948)
31. Cairo CW, Mirchev R, Golan DE (2006) Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering. Immunity 25:297-308. (Pubitemid 44224146)
32. Salas A, et al. (2002) Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1. J Biol Chem 277:50255-50262. (Pubitemid 36042173)
33. Puklin-Faucher E, et al. (2006) How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation. J Cell Biol 175:349-360. (Pubitemid 44631428)
34. Astrof NS, et al. (2006) Importance of force linkage in mechanochemistry of adhesion receptors. Biochemistry 45:15020-15028. (Pubitemid 44937014)
35. Alon R, Dustin ML (2007) Force as afacilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity 26:17-27. (Pubitemid 46109349)