Studying semblances of a true killer: Experimental model of human ventricular fibrillation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 7, 2012, Pages

  Nair, K ^a   Farid, T ^a   Masse, S ^a   Umapathy, K ^a   Watkins, S ^a   Poku, K ^a   Asta, J ^a   Kusha, M ^a   Sevaptsidis, E ^a   Jacob, J ^a   Floras, J S ^a   Nanthakumar, K ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Defibrillation threshold; Intraoperative; Mapping

Indexed keywords

ADULT; ARTICLE; CASE REPORT; DEFIBRILLATION; DEFIBRILLATION THRESHOLD TESTING; ELECTRODE; ENDOCARDIUM; FEMALE; HEART TRANSPLANTATION; HEART VENTRICLE FIBRILLATION; HUMAN; INTERMETHOD COMPARISON; ISCHEMIC CARDIOMYOPATHY; ISOLATED HEART; MALE; PRIORITY JOURNAL;

ADULT; BODY SURFACE POTENTIAL MAPPING; DATA INTERPRETATION, STATISTICAL; ELECTRIC COUNTERSHOCK; ELECTROCARDIOGRAPHY; ELECTRODES, IMPLANTED; ENDOCARDIUM; FEMALE; HEART TRANSPLANTATION; HUMANS; INTRAOPERATIVE PERIOD; MALE; MIDDLE AGED; MODELS, THEORETICAL; MYOCARDIAL ISCHEMIA; STROKE VOLUME; TACHYCARDIA, VENTRICULAR; VENTRICULAR FIBRILLATION; VENTRICULAR FUNCTION, LEFT;

EID: 84859452076     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00471.2011     Document Type: Article

References (25)

1. Chen J, Mandapati R, Berenfeld O, Skanes AC, Jalife J. Highfrequency periodic sources underlie ventricular fibrillation in the isolated rabbit heart. Circ Res 86: 86-93, 2000.
2. Chen PS, Chen LS, Cao JM, Sharifi B, Karagueuzian HS, Fishbein MC. Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death. Cardiovasc Res 50: 409-416, 2001.
3. Damle RS, Robinson NS, Ye DZ, Roth SI, Greene R, Goldberger JJ, Kadish AH. Electrical activation during ventricular fibrillation in the subacute and chronic phases of healing canine myocardial infarction. Circulation 92: 535-545, 1995.
4. Downar E, Parson ID, Mickleborough LL, Cameron DA, Yao LC, Waxman MB. On-line epicardial mapping of intraoperative ventricular arrhythmias: initial clinical experience. J Am Coll Cardiol 4: 703-714, 1984.
5. Efimov IR. Fibrillation or neurillation: back to the future in our concepts of sudden cardiac death? Circ Res 92: 1062-1064, 2003.
6. Garfinkel A, Kim YH, Voroshilovsky O, Qu Z, Kil JR, Lee MH, Karagueuzian HS, Weiss JN, Chen PS. Preventing ventricular fibrillation by flattening cardiac restitution. Proc Natl Acad Sci USA 97: 6061-6066, 2000.
7. Gray RA, Pertsov AM, Jalife J. Spatial and temporal organization during cardiac fibrillation. Nature 392: 75-78, 1998.
8. Huang J, Rogers JM, Killingsworth CR, Walcott GP, KenKnight BH, Smith WM, Ideker RE. Improvement of defibrillation efficacy and quantification of activation patterns during ventricular fibrillation in a canine heart failure model. Circulation 103: 1473-1478, 2001.
9. Kapa S, Venkatachalam KL, Asirvatham SJ. The autonomic nervous system in cardiac electrophysiology: an elegant interaction and emerging concepts. Cardiol Rev 18: 275-284.
10. Keldermann RH, Nash MP, Gelderblom H, Wang VY, Panfilov AV. Electromechanical wavebreak in a model of the human left ventricle. Am J Physiol Heart Circ Physiol 299: H134-H143, 2010.
11. Masse S, Farid T, Dorian P, Umapathy K, Nair K, Asta J, Ross H, Rao V, Sevaptsidis E, Nanthakumar K. Effect of global ischemia and reperfusion during ventricular fibrillation in myopathic human hearts. Am J Physiol Heart Circ Physiol 297: H1984-H1991, 2009.
12. Nanthakumar K, Jalife J, Masse S, Downar E, Pop M, Asta J, Ross H, Rao V, Mironov S, Sevaptsidis E, Rogers J, Wright G, Dhopeshwarkar R. Optical mapping of Langendorff-perfused human hearts: establishing a model for the study of ventricular fibrillation in humans. Am J Physiol Heart Circ Physiol 293: H875-H880, 2007.
13. Nanthakumar K, Walcott GP, Melnick S, Rogers JM, Kay MW, Smith WM, Ideker RE, Holman W. Epicardial organization of human ventricular fibrillation. Heart Rhythm 1: 14-23, 2004.
14. Nash MP, Mourad A, Clayton RH, Sutton PM, Bradley CP, Hayward M, Paterson DJ, Taggart P. Evidence for multiple mechanisms in human ventricular fibrillation. Circulation 114: 536-542, 2006.
15. Panfilov AV. Is heart size a factor in ventricular fibrillation? Or how close are rabbit and human hearts? Heart Rhythm 3: 862-864, 2006.
16. Qin H, Kay MW, Chattipakorn N, Redden DT, Ideker RE, Rogers JM. Effects of heart isolation, voltage-sensitive dye, and electromechanical uncoupling agents on ventricular fibrillation. Am J Physiol Heart Circ Physiol 284: H1818-H1826, 2003.
17. Riccio ML, Koller ML, Gilmour RF Jr. Electrical restitution and spatiotemporal organization during ventricular fibrillation. Circ Res 84: 955-963, 1999.
18. Samie FH, Mandapati R, Gray RA, Watanabe Y, Zuur C, Beaumont J, Jalife J. A mechanism of transition from ventricular fibrillation to tachycardia: effect of calcium channel blockade on the dynamics of rotating waves. Circ Res 86: 684-691, 2000.
19. Schwartz PJ. Efficacy of left cardiac sympathetic denervation has an unforeseen side effect: medicolegal complications. Heart Rhythm 7: 1330-1332, 2010.
20. Sevaptsidis E, Masse S, Parson ID, Downar E, Kimber S. Simultaneous unipolar and bipolar recording of cardiac electrical activity. Pacing Clin Electrophysiol 15: 45-51, 1992.
21. Shah RR. Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives. Br J Pharmacol 159: 58-69, 2010.
22. Umapathy K, Foomany FH, Dorian P, Farid T, Sivagangabalan G, Nair K, Masse S, Krishnan S, Nanthakumar K. Real-time electrogram analysis for monitoring coronary blood flow during human ventricular fibrillation: implications for CPR. Heart Rhythm 8: 740-749, 2011.
23. Vaidya D, Morley GE, Samie FH, Jalife J. Reentry and fibrillation in the mouse heart. A challenge to the critical mass hypothesis. Circ Res 85: 174-181, 1999.
24. Wu TJ, Ong JJ, Hwang C, Lee JJ, Fishbein MC, Czer L, Trento A, Blanche C, Kass RM, Mandel WJ, Karagueuzian HS, Chen PS. Characteristics of wave fronts during ventricular fibrillation in human hearts with dilated cardiomyopathy: role of increased fibrosis in the generation of reentry. J Am Coll Cardiol 32: 187-196, 1998.
25. Zipes DP. Heart-brain interactions in cardiac arrhythmias: role of the autonomic nervous system. Cleve Clin J Med 75, Suppl 2: S94-S96, 2008.