C-reactive protein is a more sensitive and specific marker for diagnosing bacterial infections in systemic lupus erythematosus compared to S100A8/A9 and procalcitonin

Journal of Rheumatology

Volumn 39, Issue 4, 2012, Pages 728-734

  Kim, Hyoun Ah ^a   Jeon, Ja Young ^a   An, Jeong Mi ^a   Koh, Bo Ram ^a   Suh, Chang Hee ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

C reactive protein; Infection; Procalcitonin; S100A8 A9; Systemic lupus erythematosus

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CALGRANULIN A; CALGRANULIN B; COMPLEMENT COMPONENT C3; DOUBLE STRANDED DNA ANTIBODY; PROCALCITONIN;

ADULT; ARTICLE; BACTERIAL INFECTION; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE EXACERBATION; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REMISSION; SENSITIVITY AND SPECIFICITY; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION;

ADULT; BACTERIAL INFECTIONS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CALCITONIN; CALGRANULIN A; CALGRANULIN B; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; OPPORTUNISTIC INFECTIONS; PREDICTIVE VALUE OF TESTS; PROTEIN PRECURSORS; YOUNG ADULT;

EID: 84859451087     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.111044     Document Type: Article

References (32)

1. Navarra SV, Leynes MS. Infections in systemic lupus erythematosus. Lupus 2010;19:1419-24.
2. Wadee S, Tikly M, Hopley M. Causes and predictors of death in South Africans with systemic lupus erythematosus. Rheumatology 2007;46:1487-91. (Pubitemid 47317100)
3. Suh CH, Chun HY, Ye YM, Park HS. Unresponsiveness of C-reactive protein in the non-infectious inflammation of systemic lupus erythematosus is associated with interleukin 6. Clin Immunol 2006;119:291-6.
4. Lacki JK, Leszczynski P, Kelemen J, Muller W, Mackiewicz SH. Cytokine concentration in serum of lupus erythematosus patients: The effect on acute phase response. J Med 1997;28:99-107. (Pubitemid 27306337)
5. Pepys MB, Lanham JG, De Beer FC. C-reactive protein in SLE. Clin Rheum Dis 1982;8:91-103.
6. Suh CH, Jeong YS, Park HC, Lee CH, Lee J, Song CH, et al. Risk factors for infection and role of C-reactive protein in Korean patients with systemic lupus erythematosus. Clin Exp Rheumatol 2001;19:191-4. (Pubitemid 32372457)
7. Vigushin DM, Pepys MB, Hawkins PN. Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease. J Clin Invest 1993;91:1351-7. (Pubitemid 23127332)
8. Edgeworth J, Gorman M, Bennett R, Freemont P, Hogg N. Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells. J Biol Chem 1991;266:7706-13. (Pubitemid 21906422)
9. Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 2004;50:3762-71. (Pubitemid 39643922)
10. Raquil MA, Anceriz N, Rouleau P, Tessier PA. Blockade of antimicrobial proteins S100A8 and S100A9 inhibits phagocyte migration to the alveoli in streptococcal pneumonia. J Immunol 2008;180:3366-74.
11. Striz I, Wang YM, Svarcova I, Trnka L, Sorg C, Costabel U. The phenotype of alveolar macrophages and its correlation with immune cells in bronchoalveolar lavage. Eur Respir J 1993;6:1287-94. (Pubitemid 23329544)
12. van Zoelen MA, Vogl T, Foell D, Van Veen SQ, van Till JW, Florquin S, et al. Expression and role of myeloid-related protein-14 in clinical and experimental sepsis. Am J Respir Crit Care Med 2009;180:1098-106.
13. Russwurm S, Oberhoffer M, Zipfel PF, Reinhart K. Procalcitonin - a novel biochemical marker for the mediator-directed therapy of sepsis. Mol Med Today 1999;5:286-7. (Pubitemid 29302674)
14. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993;341:515-8. (Pubitemid 23066085)
15. Soyfoo MS, Roth J, Vogl T, Pochet R, Decaux G. Phagocyte-specific S100A8/A9 protein levels during disease exacerbations and infections in systemic lupus erythematosus. J Rheumatol 2009;36:2190-4.
16. Shin KC, Lee YJ, Kang SW, Baek HJ, Lee EB, Kim HA, et al. Serum procalcitonin measurement for detection of intercurrent infection in febrile patients with SLE. Ann Rheum Dis 2001;60:988-9. (Pubitemid 32885681)
17. Brunkhorst R, Eberhardt OK, Haubitz M, Brunkhorst FM. Procalcitonin for discrimination between activity of systemic autoimmune disease and systemic bacterial infection. Intensive Care Med 2000;26 Suppl 2:S199-201. (Pubitemid 30186583)
18. Schwenger V, Sis J, Breitbart A, Andrassy K. CRP levels in autoimmune disease can be specified by measurement of procalcitonin. Infection 1998;26:274-6. (Pubitemid 28466499)
19. Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983;148:839-43. (Pubitemid 13033817)
20. Roth J, Vogl T, Sorg C, Sunderkotter C. Phagocyte-specific S100 proteins: A novel group of proinflammatory molecules. Trends Immunol 2003;24:155-8. (Pubitemid 36412096)
21. Foell D, Wittkowski H, Vogl T, Roth J. S100 proteins expressed in phagocytes: A novel group of damage-associated molecular pattern molecules. J Leukoc Biol 2007;81:28-37. (Pubitemid 46021248)
22. Vogl T, Ludwig S, Goebeler M, Strey A, Thorey IS, Reichelt R, et al. MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Blood 2004;104:4260-8. (Pubitemid 39620181)
23. Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 2007;13:1042-9. (Pubitemid 47517513)
24. Foell D, Frosch M, Sorg C, Roth J. Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammation. Clin Chim Acta 2004;344:37-51. (Pubitemid 38626135)
25. Buhaescu I, Yood RA, Izzedine H. Serum procalcitonin in systemic autoimmune diseases - Where are we now? Semin Arthritis Rheum 2010;40:176-83.
26. Karzai W, Oberhoffer M, Meier-Hellmann A, Reinhart K. Procalcitonin - A new indicator of the systemic response to severe infections. Infection 1997;25:329-34. (Pubitemid 27507299)
27. Gendrel D, Raymond J, Coste J, Moulin F, Lorrot M, Guerin S, et al. Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections. Pediatr Infect Dis J 1999;18:875-81. (Pubitemid 29487507)
28. Lanoix JP, Bourgeois AM, Schmit J, Desblache J, Salle V, Smail A, et al. Serum procalcitonin does not differentiate between infection and disease flare in patients with systemic lupus erythematosus. Lupus 2011;20:125-30.
29. Quintana G, Medina YF, Rojas C, Fernandez A, Restrepo JF, Rondon F, et al. The use of procalcitonin determinations in evaluation of systemic lupus erythematosus. J Clin Rheumatol 2008;14:138-42.
30. Tamaki K, Kogata Y, Sugiyama D, Nakazawa T, Hatachi S, Kageyama G, et al. Diagnostic accuracy of serum procalcitonin concentrations for detecting systemic bacterial infection in patients with systemic autoimmune diseases. J Rheumatol 2008;35:114-9.
31. Foell D, Wittkowski H, Roth J. Mechanisms of disease: A "DAMP" view of inflammatory arthritis. Nat Clin Pract Rheumatol 2007;3:382-90. (Pubitemid 47034539)
32. Haga HJ, Brun JG, Berntzen HB, Cervera R, Khamashta M, Hughes GR. Calprotectin in patients with systemic lupus erythematosus: relation to clinical and laboratory parameters of disease activity. Lupus 1993;2:47-50. (Pubitemid 23115237)