Sniffing out pharmacology: Interactions of drugs with human olfaction

Trends in Pharmacological Sciences

Volumn 33, Issue 4, 2012, Pages 193-199

  Lötsch, Jörn ^a   Geisslinger, Gerd ^a   Hummel, Thomas ^b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY OF DRESDEN MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOCRIPTINE; CANNABINOID; CAROVERINE; CORTICOSTEROID; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; OPIATE; OXYMETAZOLINE; REMIFENTANIL; ROFLUMILAST; SILDENAFIL; SODIUM CHANNEL NAV1.7; STEROID; TETRAHYDROCANNABINOL; THEOPHYLLINE; THIOCTIC ACID; VANILLOID RECEPTOR 1;

AMYGDALOID NUCLEUS; ANOSMIA; BLOOD BRAIN BARRIER; DRUG RECEPTOR BINDING; ENTORHINAL CORTEX; HIPPOCAMPUS; HUMAN; HYPOSMIA; INSULA; NONHUMAN; ODOR; OLFACTORY BULB; OLFACTORY DISCRIMINATION; OLFACTORY NUCLEUS; OLFACTORY SYSTEM; PATTERN RECOGNITION; PERIRHINAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHOPHYSIOLOGY; PYRIFORM CORTEX; REVIEW; SIDE EFFECT; SIGNAL TRANSDUCTION; SMELLING; SMELLING DISORDER;

ANIMALS; DRUG DISCOVERY; HUMANS; ODORS; PHARMACOLOGY; SIGNAL TRANSDUCTION; SMELL;

EID: 84859445798     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.01.004     Document Type: Review

References (78)

1. A. Keller Genetic variation in a human odorant receptor alters odour perception Nature 449 2007 468 472
2. H. Lapid Neural activity at the human olfactory epithelium reflects olfactory perception Nat. Neurosci. 14 2011 1455 1461
3. L. Buck, and R. Axel A novel multigene family may encode odorant receptors: a molecular basis for odor recognition Cell 65 1991 175 187
4. A. Rinaldi The scent of life. The exquisite complexity of the sense of smell in animals and humans EMBO Rep. 8 2007 629 633
5. B.W. Ache, and J.M. Young Olfaction: diverse species, conserved principles Neuron 48 2005 417 430
6. I. Menashe, and D. Lancet Variations in the human olfactory receptor pathway Cell. Mol. Life Sci. 63 2006 1485 1493
7. R.I Henkin Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction Drug saf. 11 1994 318 377
8. T. Hummel, and S. Nordin Olfactory disorders and their consequences for quality of life Acta Otolaryngol. 125 2005 116 121
9. G. Glusman The complete human olfactory subgenome Genome Res. 11 2001 685 702
10. Y. Gilad, and D. Lancet Population differences in the human functional olfactory repertoire Mol. Biol. Evol. 20 2003 307 314
11. I. Gaillard Olfactory receptors Cell. Mol. Life Sci. 61 2004 456 469
12. B. Malnic Combinatorial receptor codes for odors Cell 96 1999 713 723
13. D.T. Jones, and R.R. Reed Golf: an olfactory neuron specific-G protein involved in odorant signal transduction Science 244 1989 790 795
14. R. Fröhlich Ueber einige Modificationen des Geruchsinnes Akad.d.Wissenschaften Wien, math-nat. 6 1851 322 328
15. J. Lötsch Effects of the opioid remifentanil on olfactory function in healthy volunteers Life Sci. 69 2001 2279 2285
16. A. Mansour Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study J. Comp Neurol. 350 1994 412 438
17. C. Walter The effects of delta-9-tetrahydrocannabinol on nasal chemosensitivity: a pharmacological fMRI study in healthy volunteers Naunyn Schmiedebergs Arch. Pharmacol. 383 Suppl 1 2011 75
18. V. Gudziol Sildenafil affects olfactory function J. Urol. 177 2007 258 261
19. W.C. Van Staveren mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain J. Comp. Neurol. 467 2003 566 580
20. D.M. Lin Spatial patterns of gene expression in the olfactory bulb Proc. Natl. Acad. Sci. U.S.A. 101 2004 12718 12723
21. A. Toth Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain Brain Res. Mol. Brain Res. 135 2005 162 168
22. A. Patapoutian Transient receptor potential channels: targeting pain at the source Nat. Rev. Drug Discov. 8 2009 55 68
23. J.J. Cox An SCN9A channelopathy causes congenital inability to experience pain Nature 444 2006 894 898
24. J. Weiss Loss-of-function mutations in sodium channel Nav1.7 cause anosmia Nature 472 2011 186 190
25. B.L. Mania-Farnell Bromocriptine, a dopamine D2 receptor agonist, inhibits adenylyl cyclase activity in rat olfactory epithelium Neuroscience 57 1993 173 180
26. J.L. Levenson, and K. Kennedy Dysosmia, dysgeusia, and nifedipine Ann. Intern. Med. 102 1985 135 136
27. J.L. Berman Dysosmia, dysgeusia, and diltiazem Ann. Intern. Med. 102 1985 717
28. T. Maruyama Anosmia induced by amiodarone Am. J. Med. 120 2007 e9
29. A. Ghanizadeh Loss of taste and smell during treatment with topiramate Eat. Weight Disord. 14 2009 e137 e138
30. D. Lazard Odorant signal termination by olfactory UDP glucuronosyl transferase Nature 349 1991 790 793
31. P. Nef Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception J. Biol. Chem. 264 1989 6780 6785
32. H. Zumkley Zinc metabolism during captopril treatment Horm. Metab. Res. 17 1985 256 258
33. G. Neil-Dwyer, and A. Marus ACE inhibitors in hypertension: assessment of taste and smell function in clinical trials J. Hum. Hypertens. 3 Suppl. 1 1989 169 176
34. E.L. Kinney Clinical experience with amrinone in patients with advanced congestive heart failure J. Clin. Pharmacol. 22 1982 433 440
35. R. Weber Toxic drug-induced hyposmia with lovastatin Laryngorhinootologie 71 1992 483 484
36. F. Grande Toxicity of kanamycin on the organ of smell Arch. Tisiol. Mal. Appar. Respir. 20 1965 69 80
37. A. Sellari Franceschini Possible relation between olfactory acuity and sulfocyanate concentration in the nasal mucosa. III. Alterations revealed in streptomycin therapy of pulmonary tuberculosis Boll. Mal. Orecch. Gola Naso 69 1951 167 178
38. G. Jojart Olfactory inhibitor effect of gentamycin nose drops Orv. Hetil. 133 1992 577
39. A. Welge-Luessen, and M. Wolfensberger Reversible anosmia after amikacin therapy Arch. Otolaryngol. Head Neck Surg. 129 2003 1331 1333
40. A.F. Bleasel Anosmia after doxycycline use Med. J. Aust. 152 1990 440
41. S. El Aidli Recurrent dysosmia induced by pyrazinamide Fundam. Clin. Pharmacol. 23 2009 539 541
42. M. Serby Olfactory dysfunction in Alzheimer's disease and Parkinson's disease Am. J. Psychiatry 142 1985 781 782
43. J.F. Morley, and J.E. Duda Olfaction as a biomarker in Parkinson's disease Biomarkers Med. 4 2010 661 670
44. J.A. Gottfried Smell: central nervous processing Adv. Otorhinolaryngol. 63 2006 44 69
45. I. Savic Imaging of brain activation by odorants in humans Curr. Opin. Neurobiol. 12 2002 455 461
46. T. Hummel, and G. Kobal Chemosensory evoked potentials R.L. Doty, D. Müller-Schwarze, Chemical signals in vertebrates VI 1992 Plenum 565 569
47. T. Hummel, and A. Welge-Luessen Assessment of olfactory function Adv. Otorhinolaryngol. 63 2006 84 98
48. M. Damm Epidemiologie und Therapie von Riechstörungen in Deutschland, Österreich und der Schweiz HNO 52 2004 112 120
49. E.M. Haldorsen The right treatment to the right patient at the right time Occup. Environ. Med. 60 2003 235 236
50. T. Hummel 'Sniff' sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold Chem. Senses 22 1997 39 52
51. R.L. Doty, and U. Agrawal The shelf life of the University of Pennsylvania Smell Identification Test (UPSIT) Laryngoscope 99 1989 402 404
52. M. Knecht, and T. Hummel Recording of the human electro-olfactogram Physiol. Behav. 83 2004 13 19
53. W.M. Pardridge The blood-brain barrier: bottleneck in brain drug development NeuroRx 2 2005 3 14
54. G. Kobal Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation Pain 22 1985 151 163
55. I. Tegeder Peripheral opioid analgesia in experimental human pain models Brain 126 2003 1092 1102
56. K.P. Lindsey Imaging of the brain cannabinoid system Handbook Exp. Pharmacol. 2005 425 443
57. R.G. Pertwee Pharmacological actions of cannabinoids Handbook Exp. Pharmacol. 2005 1 51
58. A. Welge-Lüssen Anesthesia affects olfaction and chemosensory event-related potentials Clin. Neurophysiol. 115 2004 1384 1391
59. F. Salvinelli Permanent anosmia after topical nasal anaesthesia with lidocaine 4% Br. J. Anaesth. 95 2005 838 839
60. B.W. Jafek Anosmia after intranasal zinc gluconate use Am. J. Rhinol. 18 2004 137 141
61. T.H. Alexander, and T.M. Davidson Intranasal zinc and anosmia: the zinc-induced anosmia syndrome Laryngoscope 116 2006 217 220
62. C.L. Graff, and G.M. Pollack Nasal drug administration: potential for targeted central nervous system delivery J. Pharm. Sci. 94 2005 1187 1195
63. S.V. Dhuria Intranasal delivery to the central nervous system: mechanisms and experimental considerations J. Pharma. Sci. 99 2010 1654 1673
64. R.L. Doty The olfactory vector hypothesis of neurodegenerative disease: is it viable? Ann. Neurol. 63 2008 7 15
65. C.H. Hawkes Parkinson's disease: a dual-hit hypothesis Neuropathol. Appl. Neurobiol. 33 2007 599 614
66. C.H. Hawkes Is Parkinson's disease a primary olfactory disorder? Qjm 92 1999 473 480
67. O. Dale Nasal administration of opioids for pain management in adults Acta Anaesthesiol. Scand. 46 2002 759 770
68. L. Illum Nasal administration of morphine-6-glucuronide in sheep - a pharmacokinetic study Biopharm. Drug Dispos. 17 1996 717 724
69. J. Lötsch The transfer half-life of morphine-6-beta-glucuronide from plasma to effect site assessed by pupil size measurement in healthy volunteers Anesthesiology 95 2001 1329 1338
70. T. Hummel Effects of the nasal decongestant oxymetazoline on human olfactory and intranasal trigeminal function in acute rhinitis Eur. J. Clin. Pharmacol. 54 1998 521 528
71. A.M. Seiden, and H.J. Duncan The diagnosis of a conductive olfactory loss Laryngoscope 111 2001 9 14
72. T. Hummel, and J. Lötsch Prognostic factors of olfactory dysfunction Arch. Otolaryngol. Head Neck Surg. 136 2010 347 351
73. C. Quint The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof-of-concept study Acta Otolaryngol. 122 2002 877 881
74. T. Hummel Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract Laryngoscope 112 2002 2076 2080
75. R.I. Henkin Relative resistance to oral theophylline treatment in patients with hyposmia manifested by decreased secretion of nasal mucus cyclic nucleotides Am. J. Med. Sci. 341 2011 17 22
76. L.M. Levy Increased brain activation in response to odors in patients with hyposmia after theophylline treatment demonstrated by fMRI J. Comput. Assist. Tomogr. 22 1998 760 770
77. V. Gudziol, and T. Hummel Effects of pentoxifylline on olfactory sensitivity: a postmarketing surveillance study Arch. Otolaryngol. Head Neck Surg. 135 2009 291 295
78. ++ improves hyposmia Rhinology 43 2005 130 134