Synthesis of new bergenin derivatives as potent inhibitors of inflammatory mediators NO and TNF-α

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2744-2747

  Shah, Muhammad Raza ^a   Arfan, Mohammad ^b   Amin, Hazrat ^b   Hussain, Zahid ^a   Qadir, Muhammad Irfan ^a   Iqbal Choudhary, M ^a   Vanderveer, Donald ^c   Ahmed Mesaik, M ^a   Soomro, Samreen ^a   Jabeen, Almas ^a   Khan, Inam Ullah ^b  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b UNIVERSITY OF PESHAWAR   (Pakistan)

^c CLEMSON UNIVERSITY   (United States)

Author keywords

Anti inflammatory activity; Bergenin derivatives; Cytotoxicity, NO and TNF inhibitory activity; Neutrophil respiratory burst activity; X ray diffraction analysis

Indexed keywords

BERGENIN; BERGENIN DERIVATIVE; INDOMETACIN; KAMALA EXTRACT; N(G) METHYLARGININE; NITRIC OXIDE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; MALLOTUS PHILIPPINENSIS; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RESPIRATORY BURST; TOXICITY TESTING; X RAY DIFFRACTION;

3T3 CELLS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOPYRANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; NITRIC OXIDE; PROTEIN BINDING; TUMOR NECROSIS FACTOR-ALPHA; X-RAY DIFFRACTION;

EID: 84859442073     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.096     Document Type: Article

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