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Volumn 22, Issue 8, 2012, Pages 2902-2905

Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis

Author keywords

Alkaloids; Antimycobacterial activity; Multidrug resistant tuberculosis; Mycobacterium tuberculosis; Tiliacora triandra

Indexed keywords

13' BROMOTILIACORININE; 2' NORTILIACORININE; BISBENZYLISOQUINOLINE ALKALOID; ETHAMBUTOL; ISONIAZID; OFLOXACIN; RIFAMPICIN; STREPTOMYCIN; TILIACORINE; TILIACORININE; UNCLASSIFIED DRUG;

EID: 84859441948     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.053     Document Type: Article
Times cited : (78)

References (27)
  • 1
    • 84859443678 scopus 로고    scopus 로고
    • World Health Organization, Report: Global Tuberculosis Control. World Health Organization, Geneva, Switzerland, 2010
    • World Health Organization, Report: Global Tuberculosis Control. World Health Organization, Geneva, Switzerland, 2010
  • 11
    • 84859438635 scopus 로고    scopus 로고
    • World Health Organization. The Global Plan to Stop TB 2011-2015: Transforming the Fight Towards Elimination of Tuberculosis, 2010
    • World Health Organization. The Global Plan to Stop TB 2011-2015: Transforming the Fight Towards Elimination of Tuberculosis, 2010.
  • 12
    • 78449269332 scopus 로고    scopus 로고
    • 2 and methanol to yield tiliacorinine (1, 80 mg), 2′-nortiliacorinine (2, 39 mg), and tiliacorine (3, 14 mg). Alkaloids 1-3 were known compounds, and their spectroscopic data were identical to those reported in the following literature
    • 2 and methanol to yield tiliacorinine (1, 80 mg), 2′-nortiliacorinine (2, 39 mg), and tiliacorine (3, 14 mg). Alkaloids 1-3 were known compounds, and their spectroscopic data were identical to those reported in the following literature: (a) Patra, A.; Ghosh, S.; Mukherjee, B. Magn. Reson. Chem. 2010, 48, 823.
    • (2010) Magn. Reson. Chem. , vol.48 , pp. 823
    • Patra, A.1    Ghosh, S.2    Mukherjee, B.3
  • 14
    • 0031985277 scopus 로고    scopus 로고
    • Franzblau, S. G.; Witzig, R. S.; McLaughlin, J. C.; Torres, P.; Madico, G.; Hernandez, A.; Degnan, M. T.; Cook, M. B.; Quenzer, V. K.; Ferguson, R. M.; Gilman, R. H. J. Clin. Microbiol. 1998, 36, 362. Briefly, the tested agents were individually dissolved in DMSO, and they were diluted two-fold in 100 μl of Middlebrook 7H9GC in 96-well microplates. A mycobacterial suspension was prepared in 0.04% tween 80 and diluted with sterile distilled water to a turbidity of the McFarland no. 1. The bacterial suspension was subsequently diluted 1:50 with 7H9GC, and 100 μl was added to the wells. The highest final concentration of DMSO was 0.156% (vol/vol). The plates were incubated at 37 °C for approximately 7 days; 12.5 μl of 20% tween 80 and 20 μl of Alamar blue (SeroTec Ltd, Oxford, United Kingdom) were added to all wells. Growth of the organisms was determined after re-incubation at 37 °C for 16-24 h by visual determination of a color change from blue to pink. The MIC was defined as the lowest concentration which prevented the color change. The reference drugs, INH, RMP, EMB, SM, and OFX were used as controls (Table 1).
    • (1998) Clin. Microbiol. , vol.36 , pp. 362
    • Franzblau, S.G.1    Witzig, R.S.2    McLaughlin, J.C.3    Torres, P.4    Madico, G.5    Hernandez, A.6    Degnan, M.T.7    Cook, M.B.8    Quenzer, V.K.9    Ferguson, R.M.10    Gilman, R.H.J.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.