Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2730-2733

  Procopiou, Panayiotis A ^a   Ford, Alison J ^a   Graves, Rebecca H ^a   Hall, David A ^a   Hodgson, Simon T ^a   Lacroix, Yannick M L ^a   Needham, Deborah ^a   Slack, Robert J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antagonist; CCR4; Chemokine receptor 4; MDC; TARC

Indexed keywords

CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR4 ANTAGONIST; INDAZOLE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; DOG; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

HUMANS; INDAZOLES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, CHEMOKINE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84859440608     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.104     Document Type: Article

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