An analysis of bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein 2 from a biodegradable sponge composed of gelatin and β-tricalcium phosphate

Journal of Tissue Engineering and Regenerative Medicine

Volumn 6, Issue 4, 2012, Pages 291-298

  Fujita, N ^a   Matsushita, T ^a   Ishida, K ^a   Sasaki, K ^a   Kubo, S ^a   Matsumoto, T ^a   Kurosaka, M ^a   Tabata, Y ^b   Kuroda, R ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Bone morphogenic protein 2; Bone regeneration; Gelatin sponge; Scaffold; Tissue engineering; tricalcium phosphate

Indexed keywords

BIOMECHANICS; BONE; DEFECTS; PROTEINS; QUALITY CONTROL; SCAFFOLDS (BIOLOGY);

BONE DEFECT; BONE MORPHOGENIC PROTEIN; BONE MORPHOGENIC PROTEIN-2; BONE REGENERATION; GELATIN SPONGE; IN-VIVO; SEGMENTAL BONE DEFECT; TISSUES ENGINEERINGS; TRI-CALCIUM PHOSPHATES; Β-TRICALCIUM PHOSPHATE;

TISSUE REGENERATION;

BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATE CERAMIC; GELATIN SPONGE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DEFECT; BONE REGENERATION; CONTROLLED STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; QUALITY CONTROL; STRENGTH; TISSUE ENGINEERING;

EID: 84859427014     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.432     Document Type: Article

References (21)

1. Allen HL, Wase A, Bear WT. 1980; Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand 51: 595-600.
2. Cook SD, Salkeld SL, Brinker MR, et al. 1998; Use of an osteoinductive biomaterial (rhOP-1) in healing large segmental bone defects. J Orthop Trauma 12: 407-412.
3. Eguchi Y, Wakitani S, Naka Y, et al. 2010; An injectable composite material containing bone morphogenetic protein-2 shortens the period of distraction osteogenesis in vivo. J Orthop Res 29: 452-456.
4. Hodges NE, Perry M, Mohamed W, et al. 2006; Distraction osteogenesis versus autogenous onlay grafting. Part II: biology of regenerate and onlay bone. Int J Oral Maxillofac Implants 21: 237-244.
5. Hollinger JO, Schmitt JM, Buck DC, et al. 1998; Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res 43: 356-364.
6. Hoshino M, Egi T, Terai H, et al. 2009; Repair of long intercalated rib defects in dogs using recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and β-tricalcium phosphate. J Biomed Mater Res A 90: 514-521.
7. Jensen SS, Broggini N, Weibrich G, et al. 2005; Bone regeneration in standardized bone defects with autografts or bone substitutes in combination with platelet concentrate: a histologic and histomorphometric study in the mandibles of minipigs. Int J Oral Maxillofac Implants 20: 703-712.
8. Kawaguchi H, Oka H, Jingushi S, et al. 2010; A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: a randomized, placebo-controlled trial. J Bone Miner Res 25: 2459-2467.
9. Kempen DH, Lu L, Hefferan TE, et al. 2008; Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering. Biomaterials 29: 3245-3252.
10. Reddi AH. 1998; Initiation of fracture repair by bone morphogenetic proteins. Clin Orthop Relat Res 355: S66-72.
11. Schopper C, Moser D, Spassova E, et al. 2008; Bone regeneration using a naturally grown HA/TCP carrier loaded with rh BMP-2 is independent of barrier-membrane effects. J Biomed Mater Res A 85: 954-963.
12. Takahashi Y, Yamamoto M, Tabata Y. 2005a; Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and β-tricalcium phosphate. Biomaterials 26: 4856-4865.
13. Takahashi Y, Yamamoto M, Tabata Y. 2005b; Osteogenic differentiation of mesenchymal stem cells in biodegradable sponges composed of gelatin and β-tricalcium phosphate. Biomaterials 26: 3587-3596.
14. Wheeler DL, Chamberland DL, Schmitt JM, et al. 1998; Radiomorphometry and biomechanical assessment of recombinant human bone morphogenetic protein 2 and polymer in rabbit radius ostectomy model. J Biomed Mater Res 43: 365-373.
15. Yamamoto M, Takahashi Y, Tabata Y. 2003; Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials 24: 4375-4383.
16. Yamamoto M, Takahashi Y, Tabata Y. 2006; Enhanced bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel. Tissue Eng 12: 1305-1311.
17. Young S, Wong M, Tabata Y, et al. 2005; Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release 109: 256-274.
18. Yu YY, Lieu S, Lu C, et al. 2010; Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair. Bone 47: 65-73.
19. Zegzula HD, Buck DC, Brekke J, et al. 1997; Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein-2). J Bone Joint Surg Am 79: 1778-1790.
20. Zekorn D. 1969; Intravascular retention, dispersal, excretion and breakdown of gelatin plasma substitutes. Bibl Haematol 33: 131-140.
21. Zerbo IR, Bronckers AL, de Lange GL, et al. 2001; Histology of human alveolar bone regeneration with a porous tricalcium phosphate. A report of two cases. Clin Oral Implants Res 12: 379-384.