Role of rapamycin-induced autophagy in pancreatic islets

American Journal of Transplantation

Volumn 12, Issue 4, 2012, Pages 1067-

  Tanemura, M ^a,b   Nagano, H ^a   Taniyam, K ^b   Kamiike, W ^b   Mori, M ^a   Doki, Y ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BAFILOMYCIN A1; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; RAPAMYCIN; UNCLASSIFIED DRUG; WORTMANNIN;

ACIDIFICATION; APOPTOSIS; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; DRUG EFFECT; LETTER; MOLECULAR INTERACTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANIMALS; AUTOPHAGY; ISLETS OF LANGERHANS; SIROLIMUS; UP-REGULATION;

EID: 84859423583     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2011.03933.x     Document Type: Letter

References (5)

1. Tanemura M, Ohmura Y, Deguchi T, et al. Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo. Am J Transplant 2012; 12: 102-114.
2. Pallet N. The presence of autophagy in mammal cells should be interpreted carefully. Am J Transplant 2012; doi: 10.1111/j.1600-6143.2011.03935.x
3. Itakura E, Kishi C, Inoue K, Mizushima N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 2008; 19: 5360-5372.
4. Klionsky DJ, Elazar Z, Seglen PO, Rubinsztein DC. Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy 2008; 4: 849-950.
5. Chen G, Hu X, Zhang W, et al. Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells. Apoptosis 2011; Sep 29. doi: 10.1007/s10495-011-0658-1.