Pyruvate therapy for mitochondrial DNA depletion syndrome

Biochimica et Biophysica Acta - General Subjects

Volumn 1820, Issue 5, 2012, Pages 632-636

  Saito, Keiko ^a   Kimura, Nobusuke ^a,d   Oda, Nozomi ^a   Shimomura, Hideki ^a   Kumada, Tomohiro ^a   Miyajima, Tomoko ^a   Murayama, Kei ^b   Tanaka, Masashi ^c   Fujii, Tatsuya ^a  

^a Shiga Medical Center for Children   (Japan)

^b CHIBA CHILDREN'S HOSPITAL   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^d SHIZUOKA INSTITUTE OF EPILEPSY AND NEUROLOGICAL DISORDERS   (Japan)

Author keywords

Lactate to pyruvate ratio; Mitochondrial diseases; Mitochondrial DNA depletion syndrome; NAD +; Pyruvate therapy; Treatment

Indexed keywords

ALANINE AMINOTRANSFERASE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CARNITINE; LACTIC ACID; PYRUVATE SODIUM; THIAMINE; UBIQUINONE;

ARTICLE; CASE REPORT; CHILD; CLINICAL EVALUATION; COMPLEX I DEFICIENCY; COMPLEX II DEFICIENCY; CYTOCHROME C OXIDASE DEFICIENCY; DIARRHEA; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; FUNCTIONAL ASSESSMENT; GENE DOSAGE; HUMAN; HUMAN TISSUE; INFANT; LACTIC ACIDOSIS; MEDICAL HISTORY; MITOCHONDRIAL DNA DEPLETION SYNDROME; MUSCLE STRENGTH; NEWBORN ASSESSMENT; NEWCASTLE PAEDIATIC MITOCHONDRIAL DISEASE SCALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EXAMINATION; PRIORITY JOURNAL; QUALITY OF LIFE; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; TASK PERFORMANCE; TREATMENT DURATION;

DNA, MITOCHONDRIAL; FEMALE; HUMANS; INFANT; MITOCHONDRIAL DISEASES; PYRUVIC ACID; SYNDROME;

EID: 84859420751     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2011.08.006     Document Type: Article

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