Cutting edge: Nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1

Journal of Immunology

Volumn 188, Issue 7, 2012, Pages 2977-2980

  Norton, John T ^a   Hayashi, Tomoko ^a   Crain, Brian ^a   Cho, John S ^b   Miller, Lloyd S ^b   Corr, Maripat ^c   Carson, Dennis A ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; CLODRONIC ACID; COMPOUND 48-80; CROMOGLYCATE DISODIUM; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MEVINOLIN; MYELOID DIFFERENTIATION FACTOR 88; PAMIDRONIC ACID; ZOLEDRONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE RESISTANCE; DRUG SENSITIVITY; INFLAMMATION; LYMPHOCYTE; MAST CELL; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALENDRONATE; ANIMALS; CHEMOTAXIS; CLODRONIC ACID; DIPHOSPHONATES; IMIDAZOLES; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; LEUKOCYTES; MAST CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MYELOID DIFFERENTIATION FACTOR 88; NEUTROPHILS; PERITONITIS; RECEPTORS, INTERLEUKIN-1;

EID: 84859377311     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100830     Document Type: Article

References (22)

1. Clezardin, P. 2011. Bisphosphonates' antitumor activity: an unravelled side of a multifaceted drug class. Bone 48: 71-79.
2. Roelofs, A. J., K. Thompson, F. H. Ebetino, M. J. Rogers, and F. P. Coxon. 2010. Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages. Curr. Pharm. Des. 16: 2950-2960.
3. Papapetrou, P. D. 2009. Bisphosphonate-associated adverse events. Hormones (Athens) 8: 96-110.
4. Lesclous, P., S. Abi Najm, J. P. Carrel, B. Baroukh, T. Lombardi, J. P. Willi, R. Rizzoli, J. L. Saffar, and J. Samson. 2009. Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation? Bone 45: 843-852.
5. Roelofs, A. J., M. Jauhiainen, H. Mönkkönen, M. J. Rogers, J. Mönkkönen, and K. Thompson. 2009. Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. Br. J. Haematol. 144: 245-250.
6. Yamaguchi, K., K. Motegi, Y. Iwakura, and Y. Endo. 2000. Involvement of interleukin-1 in the inflammatory actions of aminobisphosphonates in mice. Br. J. Pharmacol. 130: 1646-1654. (Pubitemid 30611944)
7. Deng, X., Z. Yu, H. Funayama, N. Shoji, T. Sasano, Y. Iwakura, S. Sugawara, and Y. Endo. 2006. Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate. Toxicol. Appl. Pharmacol. 213: 64-73.
8. Norton, J. T., T. Hayashi, B. Crain, M. Corr, and D. A. Carson. 2011. Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates. Proc. Natl. Acad. Sci. USA 108: 11163-11168.
9. Brydges, S. D., J. L. Mueller, M. D. McGeough, C. A. Pena, A. Misaghi, C. Gandhi, C. D. Putnam, D. L. Boyle, G. S. Firestein, A. A. Horner, et al. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30: 875-887.
10. Eisenbarth, S. C., O. R. Colegio, W. O'Connor, F. S. Sutterwala, and R. A. Flavell. 2008. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453: 1122-1126. (Pubitemid 351871731)
11. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4: 499-511. (Pubitemid 38931765)
12. Guma, M., J. Kashiwakura, B. Crain, Y. Kawakami, B. Beutler, G. S. Firestein, T. Kawakami, M. Karin, and M. Corr. 2010. JNK1 controls mast cell degranulation and IL-1beta production in inflammatory arthritis. Proc. Natl. Acad. Sci. USA 107: 22122-22127.
13. Horai, R., M. Asano, K. Sudo, H. Kanuka, M. Suzuki, M. Nishihara, M. Takahashi, and Y. Iwakura. 1998. Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J. Exp. Med. 187: 1463-1475. (Pubitemid 28215405)
14. Hayashi, T., H. B. Cottam, M. Chan, G. Jin, R. I. Tawatao, B. Crain, L. Ronacher, K. Messer, D. A. Carson, and M. Corr. 2008. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295: R123-R132.
15. Bot, J., D. Whitaker, J. Vivian, R. Lake, V. Yao, and R. McCauley. 2003. Culturing mouse peritoneal mesothelial cells. Pathol. Res. Pract. 199: 341-344. (Pubitemid 36939586)
16. Kuehn, H. S., M. Radinger, and A. M. Gilfillan. 2010. Measuring mast cell mediator release. In Current Protocols in Immunology. Coligan, J. E., ed. Wiley Interscience, New York, Chapter 7, Unit 7, p. 38.
17. Deng, X., Z. Yu, H. Funayama, K. Yamaguchi, T. Sasano, S. Sugawara, and Y. Endo. 2007. Histidine decarboxylase-stimulating and inflammatory effects of alendronate in mice: involvement of mevalonate pathway, TNFalpha, macrophages, and T-cells. Int. Immunopharmacol. 7: 152-161. (Pubitemid 46037554)
18. Mombaerts, P. 1995. Lymphocyte development and function in T-cell receptor and RAG-1 mutant mice. Int. Rev. Immunol. 13: 43-63.
19. Thompson, K., A. J. Roelofs, M. Jauhiainen, H. Mönkkönen, J. Mönkkönen, and M. J. Rogers. 2010. Activation of gd T cells by bisphosphonates. Adv. Exp. Med. Biol. 658: 11-20.
20. Rogers, M. J., J. C. Crockett, F. P. Coxon, and J. Mönkkönen. 2011. Biochemical and molecular mechanisms of action of bisphosphonates. Bone 49: 34-41.
21. Eigenbrod, T., J. H. Park, J. Harder, Y. Iwakura, and G. Núñez. 2008. Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells. J. Immunol. 181: 8194-8198.
22. Lin, J. H., D. E. Duggan, I. W. Chen, and R. L. Ellsworth. 1991. Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals. Drug Metab. Dispos. 19: 926-932.