Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications

Cell Death and Disease

Volumn 3, Issue 3, 2012, Pages

  Gogna, R ^a   Madan, E ^a   Kuppusamy, P ^b   Pati, U ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Hypoxia; Mutant rescue; Oxygenation; p53; Tumor regression

Indexed keywords

DNA; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL HYPOXIA; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA REPAIR; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; REOXYGENATION; TUMOR REGRESSION;

ACETYLATION; ANIMALS; APOPTOSIS; CELL HYPOXIA; CELL LINE, TUMOR; GENES, REPORTER; HUMANS; LUCIFERASES; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; OXYGEN; PHOSPHORYLATION; PLASMIDS; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84859371685     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.15     Document Type: Article

References (22)

1. Daruwalla J, Christophi C. Hyperbaric oxygen therapy for malignancy: a review. World J Surg 2006; 30: 2112-2131. (Pubitemid 44885165)
2. Gill AL, Bell CN. Hyperbaric oxygen: its uses, mechanisms of action and outcomes. QJM Mon J Assoc Phys 2004; 97: 385-395. (Pubitemid 38967412)
3. Gothard L, Haviland J, Bryson P, Laden G, Glover M, Harrison S et al. Randomised phase II trial of hyperbaric oxygen therapy in patients with chronic arm lymphoedema after radiotherapy for cancer. Radiother Oncol J Eur Soc Therapeutic Radiol Oncol 2010; 97: 101-107.
4. Stuhr LE, Raa A, Oyan AM, Kalland KH, Sakariassen PO, Petersen K et al. Hyperoxia retards growth and induces apoptosis, changes in vascular density and gene expression in transplanted gliomas in nude rats. J Neuro-Oncol 2007; 85: 191-202. (Pubitemid 47629400)
5. Selvendiran K, Kuppusamy ML, Ahmed S, Bratasz A, Meenakshisundaram G, Rivera BK et al. Oxygenation inhibits ovarian tumor growth by downregulating STAT3 and cyclin-D1 expressions. Cancer Biol Ther 2010; 10: 386-390.
6. Chavko M, Xing G, Keyser DO. Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activation. Brain Res 2001; 900: 227-233. (Pubitemid 32382116)
7. Plafki C, Peters P, Almeling M, Welslau W, Busch R. Complications and side effects of hyperbaric oxygen therapy. Aviat Space Environ Med 2000; 71: 119-124. (Pubitemid 30070823)
8. Erkkila K, Pentikainen V, Wikstrom M, Parvinen M, Dunkel L. Partial oxygen pressure and mitochondrial permeability transition affect germ cell apoptosis in the human testis. J Clin Endocrinol Metabol 1999; 84: 4253-4259. (Pubitemid 30644226)
9. Sermeus A, Michiels C. Reciprocal influence of the p53 and the hypoxic pathways. Cell Death Disease 2011; 2: e164.
10. Kim BM, Choi JY, Kim YJ,Woo HD, Chung HW. Reoxygenation following hypoxia activates DNA-damage checkpoint signaling pathways that suppress cell-cycle progression in cultured human lymphocytes. FEBS Lett 2007; 581: 3005-3012. (Pubitemid 46899042)
11. Shenberger JS, Dixon PS. Oxygen induces S-phase growth arrest and increases p53 and p21(WAF1/CIP1) expression in human bronchial smooth-muscle cells. Am J Resp Cell Mol Biol 1999; 21: 395-402. (Pubitemid 129517194)
12. Gogna R, Madan E, Kuppusamy P, Pati U. Chaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression. J Biol Chem 2012; 287: 2907-2914.
13. Weinmann M, Jendrossek V, Guner D, Goecke B, Belka C. Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways. FASEB J Off Pub Federation Am Soc Exp Biol 2004; 18: 1906-1908. (Pubitemid 39602279)
14. Moulder JE, Rockwell S. Tumor hypoxia: its impact on cancer therapy. Cancer Metast Rev 1987; 5: 313-341.
15. Gogna R, Madan E, Kuppusamy P, Pati U. Reactive oxygen species-mediated p53 core-domain modifications determine apoptotic or necrotic death in cancer cells. Antioxidants Redox Signal 2012; 16: 400-412.
16. Achison M, Hupp TR. Hypoxia attenuates the p53 response to cellular damage. Oncogene 2003; 22: 3431-3440. (Pubitemid 36713741)
17. Gudkov AV, Komarova EA. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 2003; 3: 117-129. (Pubitemid 37328879)
18. Steelman LS, Martelli AM, Nicoletti F, McCubrey JA. Exploiting p53 status to enhance effectiveness of chemotherapy by lowering associated toxicity. Oncotarget 2011; 2: 109-112.
19. Wouters BG, Brown JM. Cells at intermediate oxygen levels can be more important than the 'hypoxic fraction' in determining tumor response to fractionated radiotherapy. Radiation Res 1997; 147: 541-550. (Pubitemid 27204090)
20. Postovit LM, Abbott DE, Payne SL, Wheaton WW, Margaryan NV, Sullivan R et al. Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration. J Cell Biochem 2008; 103: 1369-1378. (Pubitemid 351490707)
21. Meek DW, Anderson CW. Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harbor Perspect Biol 2009; 1: a000950.
22. Pandian RP, Parinandi NL, Ilangovan G, Zweier JL, Kuppusamy P. Novel particulate spin probe for targeted determination of oxygen in cells and tissues. Free Radical Biol Med 2003; 35: 1138-1148. (Pubitemid 37315706)