Bone regeneration in distraction osteogenesis demonstrates significantly increased vascularity in comparison to fracture repair in the mandible

Journal of Craniofacial Surgery

Volumn 23, Issue 1, 2012, Pages 328-332

  Donneys, Alexis ^a   Tchanque Fossuo, Catherine N ^a   Farberg, Aaron S ^a   Deshpande, Sagar S ^a   Buchman, Steven R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Angiogenesis; Craniofacial surgery; Distraction osteogenesis; Mandibular fracture repair; Micro computed tomography; Vascularity; Vessel perfusion

Indexed keywords

FIXATIVE; FORMALDEHYDE; SILASTIC;

ANGIOGRAPHY; ANIMAL; ARTICLE; BONE REGENERATION; CHEMISTRY; COMPARATIVE STUDY; DISTRACTION OSTEOGENESIS; EXTERNAL FIXATOR; FRACTURE HEALING; INSTRUMENTATION; MALE; MANDIBLE; MANDIBLE FRACTURE; METHODOLOGY; MICRO-COMPUTED TOMOGRAPHY; MICROVASCULATURE; OSTEOTOMY; PHYSIOLOGY; RADIOGRAPHY; RAT; SPRAGUE DAWLEY RAT; THREE DIMENSIONAL IMAGING; TIME; VASCULARIZATION;

ANGIOGRAPHY; ANIMALS; BONE REGENERATION; EXTERNAL FIXATORS; FIXATIVES; FORMALDEHYDE; FRACTURE HEALING; IMAGING, THREE-DIMENSIONAL; MALE; MANDIBLE; MANDIBULAR FRACTURES; MICROVESSELS; OSTEOGENESIS, DISTRACTION; OSTEOTOMY; RATS; RATS, SPRAGUE-DAWLEY; SILICONE ELASTOMERS; TIME FACTORS; X-RAY MICROTOMOGRAPHY;

EID: 84859362960     PISSN: 10492275     EISSN: None     Source Type: Journal    
DOI: 10.1097/SCS.0b013e318241db26     Document Type: Article

References (23)

1. AI-Aql ZS, Alagl AS, Graves DT, et al. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res 2008;87:107-118
2. Tong L, Buchman SR, Ignelzi MA, et al. Focal adhesion kinase expression during mandibular distraction osteogenesis: evidence for mechanotransduction. Plastic Reconstr Surg 2003;111:211-222
3. Fang TD, Salim A, Xia W, et al. Angiogenesis is required for successful bone induction during distraction osteogenesis. J Bone Miner Res 2005;20:1114-1124
4. McCarthy JG, Stelnicki EJ, Mehrara BJ, et al. Special topic distraction osteogenesis of the craniofacial skeleton. Plast Reconstr Surg 2001;107:1812-1827
5. Aronson J. Temporal and spatial increases in blood flow during distraction osteogenesis. Clin Orthop Relat Res 1994;124-131
6. Aronson J. Experimental and clinical experience with distraction osteogenesis. Cleft Palate Craniofac J 1994;31:473-481
7. Rowe NM, Mehrara BJ, Luchs JS, et al. Angiogenesis during distraction osteogenesis. Ann Plast Surg 1999;42:470-475
8. Pacicca D. Expression of angiogenic factors during distraction osteogenesis. Bone 2003;33:889-898
9. Donneys A, Farberg A, Tchanque-Fossuo C, et al. Angiogenic effect of deferoxamine in mandibular distraction osteogenesis. Plast Reconstr Surg 2010;125:130
10. Wan C, Gilbert SR, Wang Y, et al. Activation of the hypoxia-inducible factor-1> pathway accelerates bone regeneration. Proc Natl Acad Sci USA 2008;105:686-691
11. Shen X, Wan C, Ramaswamy G, et al. Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice. J Orthop Res 2009;27:1298-1305
12. Street J, Bao M, DeGuzman L, et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 2002;99: 9656-9661
13. Duvall CL, Taylor WR, Weiss D, et al. Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury. Am J Physiol 2004;287:H302-H310
14. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues: Part I. The influence of stability of fixation and soft tissue preservation. Clin Orthop Relat Res 1989;238:249-281
15. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. Clin Orthop Relat Res 1989;239:263-285
16. Ilizarov GA, Ledyaev VI. The replacement of long tubular bone defects by lengthening distraction osteotomy of one of the fragments. Clin Orthop Relat Res 1992;280:7-10
17. Williams E, Rand J, An K, et al. The early healing of tibial osteotomies stabilized by one-plane or two-plane external fixation. J Bone Joint Surg Am 1987;69:355-365
18. Wu J, Shyr H, Chao E, et al. Comparison of osteotomy healing under external fixation devices with different stiffness characteristics. J Bone Joint Surg Am 1984;66:1258-1264
19. Jing X, Farberg A, Monson L, et al. Radiomorphometric quantitative analysis of vasculature in rat mandible utilizing microcomputed tomography. Plast Reconstr Surg 2009;124:26-27
20. Donneys A, Tchanque-Fossuo CN, Farberg AS, et al. Quantitative analysis of vascular response after mandibular fracture repair utilizing microYcomputed tomography with vessel perfusion. Plast Reconstr Surg 2010;126:5-6
21. Buchman SR, Ignelzi MA, Wilensky J, et al. Unique rodent model of distraction osteogenesis of the mandible. Ann Plast Surg 2002;49:511-519
22. Huelke DF, Castelli WA. The blood supply of the rat mandible. Anat Rec 1965;153:335-341
23. Glowacki J. Angiogenesis in fracture repair. Clin Orthop Relat Res 1998;355:S82