ADMA and NOS regulation in chronic renal disease: Beyond the old rivalry for L-arginine

Kidney International

Volumn 81, Issue 8, 2012, Pages 722-724

  Dobrian, Anca D ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; UNCLASSIFIED DRUG;

AMINO ACID BLOOD LEVEL; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GLOMERULUS FILTRATION RATE; HUMAN; MOLECULAR PATHOLOGY; NONHUMAN; NOTE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; VASODILATATION;

EID: 84859361707     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.496     Document Type: Note

References (10)

1. Sibal L, Agarwal SC, Home PD et al. The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease. Curr Cardiol Rev 2010;6:82-90.
2. Zoccali C, Bode-Boger S, Mallamaci F et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study. Lancet 2001;358: 2113-2117. (Pubitemid 34094901)
3. Kajimoto H, Kai H, Aoki H et al. Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine. Kidney Int 2012;81:762-768.
4. Palm F, Onozato ML, Luo Z et al. Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 2007; 293:H3227-H3245. (Pubitemid 350230862)
5. Vallance P, Leone A, Calver A et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992;339:572-575.
6. Zoccali C. Asymmetric dimethylarginine (ADMA): a cardiovascular and renal risk factor on the move. J Hypertens 2006;24:611-619.
7. Boger GI, Rudolph TK, Maas R et al. Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: effect of combination with oral L-arginine. J Am Coll Cardiol 2007;49:2274-2282. (Pubitemid 46856823)
8. Rafikov R, Fonseca FV, Kumar S et al. eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J Endocrinol 2011;210:271-284.
9. Feliers D, Chen X, Akis N et al. VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells. Kidney Int 2005;68:1648-1659. (Pubitemid 43169910)
10. Ruan L, Torres CM, Qian J et al. Pin1 prolyl isomerase regulates endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol 2011;31:392-398.