Blindness following cosmetic injections of the face

Plastic and Reconstructive Surgery

Volumn 129, Issue 4, 2012, Pages 995-1012

  Lazzeri, Davide ^a   Agostini, Tommaso ^a   Figus, Michele ^a   Nardi, Marco ^a   Pantaloni, Marcello ^a   Lazzeri, Stefano ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLINDNESS; ESTHETIC SURGERY; FACE; HUMAN; INJECTION; RETINA ARTERY OCCLUSION; REVIEW;

BLINDNESS; COSMETIC TECHNIQUES; FACE; HUMANS; INJECTIONS; RETINAL ARTERY OCCLUSION;

EID: 84859344059     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e3182442363     Document Type: Article

References (89)

1. Eppley BL, Dadvand B. Injectable soft-tissue fillers: Clinical overview. Plast Reconstr Surg. 2006;118:98e-106e.
2. Coleman SR. Structural fat grafting: More than a permanent filler. Plast Reconstr Surg. 2006;118(Suppl):108S-120S.
3. Teimourian B. Blindness following fat injections. Plast Reconstr Surg. 1988;82:361.
4. Dreizen NG, Framm L. Sudden unilateral visual loss after autologous fat injection into the glabellar area. Am J Ophthalmol. 1989;107:85-87.
5. Egido JA, Arroyo R, Marcos A, Jiménez-Alfaro I. Middle cerebral artery embolism and unilateral visual loss after autologous fat injection into the glabellar area. Stroke 1993;24: 615-616.
6. Lee DH, Yang HN, Kim JC, Shyn KH. Sudden unilateral visual loss and brain infarction after autologous fat injection into nasolabial groove. Br J Ophthalmol. 1996;80:1026-1027.
7. Feinendegen DL, Baumgartner RW, Vuadens P, et al. Autologous fat injection for soft tissue augmentation in the face: A safe procedure? Aesthetic Plast Surg. 1998;22:163-167.
8. Danesh-Meyer HV, Savino PJ, Sergott RC. Case reports and small case series: Ocular and cerebral ischemia following facial injection of autologous fat. Arch Ophthalmol. 2001;119: 777-778.
9. Coleman SR. Avoidance of arterial occlusion from injection of soft tissue fillers. Aesthet Surg J. 2002;22:555-557.
10. Yoon SS, Chang DI, Chung KC. Acute fatal stroke immediately following autologous fat injection into the face. Neurology 2003;61:1151-1152.
11. Allali J, Bernard A, Assaraf E, Bourges JL, Renard G. Multiple embolizations of the branches of the ophthalmic artery: An unknown serious complication of facial surgeries (in French). J Fr Ophtalmol. 2006;29:51-57.
12. Mori K, Ohta K, Nagano S, Toshinori M, Yago T, Ichinose Y. A case of ophthalmic artery obstruction following autologous fat injection in the glabellar area (in Japanese). Nippon Ganka Gakkai Zasshi 2007;111:22-25.
13. Park SH, Sun HJ, Choi KS. Sudden unilateral visual loss after autologous fat injection into the nasolabial fold. Clin Ophthalmol. 2008;2:679-683.
14. Lee YJ, Kim HJ, Choi KD, Choi HY. MRI restricted diffusion in optic nerve infarction after autologous fat transplantation. J Neuroophthalmol. 2010;30:216-218.
15. Park SJ, Woo SJ, Park KH, et al. Partial recovery after intraarterial pharmacomechanical thrombolysis in ophthalmic artery occlusion following nasal autologous fat injection. J Vasc Interv Radiol. 2011;22:251-254.
16. von Bahr G. Multiple embolisms in the fundus of an eye after an injection in the scalp. Acta Ophthalmol (Copenh.) 1963;41: 85-91.
17. Lee JH, Lee KH, Moon HJ. A case of unilateral blindness after paraffin injection on the forehead. J Korean Ophthalmol Soc. 1969;10:49-51.
18. Selmanowitz VJ, Orentreich N. Cutaneous corticosteroid injection and amaurosis: Analysis for cause and prevention. Arch Dermatol. 1974;110:729-734.
19. Shin H, Lemke BN, Stevens TS, Lim MJ. Posterior ciliaryartery occlusion after subcutaneous silicone-oil injection. Ann Ophthalmol. 1988;20:342-344.
20. Castillo GD. Management of blindness in the practice of cosmetic surgery. Otolaryngol Head Neck Surg. 1989;100:559-562.
21. Shafir R, Cohen M, Gur E. Blindness as a complication of subcutaneous nasal steroid injection. Plast Reconstr Surg. 1999;104:1180-1182; discussion 1183-1184.
22. Jee DH, Lee KI. A case of left ophthalmic artery occlusion and right carotid cavernous fistula after illegal rhinoplasty. J Korean Ophthalmol Soc. 2002;43:898-904.
23. Apte RS, Solomon SD, Gehlbach P. Acute choroidal infarction following subcutaneous injection of micronized dermal matrix in the forehead region. Retina 2003;23:552-554.
24. Silva MT, Curi AL. Blindness and total ophthalmoplegia after aesthetic polymethylmethacrylate injection: Case report. Arq Neuropsiquiatr. 2004;62:873-874.
25. Kubota T, Hirose H. Permanent loss of vision following cosmetic rhinoplastic surgery. Jpn J Ophthalmol. 2005;49:535-536.
26. Peter S, Mennel S. Retinal branch artery occlusion following injection of hyaluronic acid (Restylane). Clin Experiment Ophthalmol. 2006;34:363-364.
27. Kang YS, Kim JW, Choi WS, Park HS, Jang SJ, Chio JC. A case of sudden unilateral visual loss following injection of filler into the glabella. Korean J Dermatol. 2007;45:381-383.
28. Tangsirichaipong A. Blindness after facial contour augmentation with injectable silicone. J Med Assoc Thai. 2009; 92(Suppl 3):S85-S87.
29. Sung MS, Kim HG, Woo KI, Kim YD. Ocular ischemia and ischemic oculomotor nerve palsy after vascular embolization of injectable calcium hydroxyapatite filler. Ophthal Plast Reconstr Surg. 2010;26:289-291.
30. Kwon DY, Park MH, Koh SB, et al. Multiple arterial embolism after illicit intranasal injection of collagenous material. Dermatol Surg. 2010;36:1196-1199.
31. Kim YJ, Kim SS, Song WK, Lee SY, Yoon JS. Ocular ischemia with hypotony after injection of hyaluronic acid gel. Ophthal Plast Reconstr Surg. 2011;27:e152-e155.
32. Byers B. Blindness secondary to steroid injections into the nasal turbinates. Arch Ophthalmol. 1979;97:79-80.
33. Mabry RL. Visual loss after intranasal corticosteroid injection: Incidence, causes, and prevention. Arch Otolaryngol. 1981;107:484-486.
34. Mabry RL. Intranasal corticosteroid injection: Indications, technique, and complications. Otolaryngol Head Neck Surg. 1979;87:207-211.
35. Whiteman DW, Rosen DA, Pinkerton RM. Retinal and choroidal microvascular embolism after intranasal corticosteroid injection. Am J Ophthalmol. 1980;89:851-853.
36. Wilkinson WS, Morgan CM, Baruh E, Gitter KA. Retinal and choroidal vascular occlusion secondary to corticosteroid embolisation. Br J Ophthalmol. 1989;73:32-34.
37. Savino PJ, Burde RM, Mills RP. Visual loss following intranasal anesthetic injection. J Clin Neuroophthalmol. 1990;10: 140-144.
38. Cheney ML, Blair PA. Blindness as a complication of rhinoplasty. Arch Otolaryngol Head Neck Surg. 1987;113:768-769.
39. Rettinger G, Christ P, Meythaler FH. Blindness caused by central artery occlusion following nasal septum correction (in German). HNO. 1990;38:105-109.
40. Meythaler FH, Naumann GO. Intraocular ischemic infarcts in injections into the lid and parabulbar region (without perforation of the eye) (in German). Klin Monbl Augenheilkd. 1987;190:474-477.
41. Rishiraj B, Epstein JB, Fine D, Nabi S, Wade NK. Permanent vision loss in one eye following administration of local anesthesia for a dental extraction. Int J Oral Maxillofac Surg. 2005;34:220-223.
42. Ellis PP. Visual loss following tonsillectomy; possible association with injections in tonsillar fossae. Arch Otolaryngol. 1968; 87:436-438.
43. McGrew RN, Wilson RS, Havener WH. Sudden blindness secondary to injections of common drugs in the head and neck: I. Clinical experiences. Otolaryngology 1978;86:147-151.
44. Fivgas GD, Newman NJ. Anterior ischemic optic neuropathy following the use of a nasal decongestant. Am J Ophthalmol. 1999;127:104-106.
45. Chamot L, Zografos L, Micheli JL. Ocular and orbital complications after sclerosing injections in a case of a frontal cutaneous angioma. Ophthalmologica 1981;182:193-198.
46. Shorr N, Seiff SR. Central retinal artery occlusion associated with periocular corticosteroid injection for juvenile hemangioma. Ophthalmic Surg. 1986;17:229-231.
47. Ruttum MS, Abrams GW, Harris GJ, Ellis MK. Bilateral retinal embolization associated with intralesional corticosteroid injection for capillary hemangioma of infancy. J Pediatr Ophthalmol Strabismus 1993;30:4-7.
48. Egbert JE, Schwartz GS, Walsh AW. Diagnosis and treatment of an ophthalmic artery occlusion during an intralesional injection of corticosteroid into an eyelid capillary hemangioma. Am J Ophthalmol. 1996;121:638-642.
49. Gupta V, Sharma SC, Gupta A, Dogra MR. Retinal and choroidal microvascular embolization with methylprednisolone. Retina 2002;22:382-386.
50. Edwards AO. Central retinal artery occlusion following forehead injection with a corticosteroid suspension. Pediatr Dermatol. 2008;25:460-461.
51. Matsuo T, Fujiwara H, Gobara H, Mimura H, Kanazawa S. Central retinal and posterior ciliary artery occlusion after intralesional injection of sclerosant to glabellar subcutaneous hemangioma. Cardiovasc Intervent Radiol. 2009;32:341-346.
52. Thomas EL, Laborde RP. Retinal and choroidal vascular occlusion following intralesional corticosteroid injection of a chalazion. Ophthalmology 1986;93:405-407.
53. Yaǧci A, Palamar M, Eǧrilmez S, Sahbazov C, Ozbek SS. Anterior segment ischemia and retinochoroidal vascular occlusion after intralesional steroid injection. Ophthal Plast Reconstr Surg. 2008;24:55-57.
54. Egbert JE, Paul S, Engel WK, Summers CG. High injection pressure during intralesional injection of corticosteroids into capillary hemangiomas. Arch Ophthalmol. 2001;119: 677-683.
55. Bachmann F, Erdmann R, Hartmann V, Wiest L, Rzany B. The spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: Results from the Injectable Filler Safety Study. Dermatol Surg. 2009;35(Suppl 2): 1629-1634.
56. Bellman B. Complication following suspected intra-arterial injection of Restylane. Aesthet Surg J. 2006;26:304-305.
57. Georgescu D, Jones Y, McCann JD, Anderson RL. Skin necrosis after calcium hydroxyapatite injection into the glabellar and nasolabial folds. Ophthal Plast Reconstr Surg. 2009;25: 498-499.
58. Glaich AS, Cohen JL, Goldberg LH. Injection necrosis of the glabella: Protocol for prevention and treatment after use of dermal fillers. Dermatol Surg. 2006;32:276-281.
59. Hanke CW, Higley HR, Jolivette DM, Swanson NA, Stegman SJ. Abscess formation and local necrosis after treatment with Zyderm or Zyplast collagen implant. J Am Acad Dermatol. 1991;25:319-326.
60. Inoue K, Sato K, Matsumoto D, Gonda K, Yoshimura K. Arterial embolization and skin necrosis of the nasal ala following injection of dermal fillers. Plast Reconstr Surg. 2008; 21:127e-128e.
61. Hirsch RJ, Lupo M, Cohen JL, Duffy D. Delayed presentation of impending necrosis following soft tissue augmentation with hyaluronic acid and successful management with hyaluronidase. J Drugs Dermatol. 2007;6:325-328.
62. Park TH, Seo SW, Kim JK, Chang CH. Clinical experience with hyaluronic acid-filler complications. J Plast Reconstr Aesthet Surg. 2011;64:892-896.
63. Schanz S, Schippert W, Ulmer A, Rassner G, Fierlbeck G. Arterial embolization caused by injection of hyaluronic acid (Restylane). Br J Dermatol. 2002;146:928-929.
64. Lowe NJ. Arterial embolization caused by injection of hyaluronic acid (Restylane). Br J Dermatol. 2003;148:379; author reply 379-380.
65. Paul S, Egbert JE, Walsh AW, Hoey MF. Pressure measurements during injection of corticosteroids. Med Biol Eng Comput. 1998;36:729-733.
66. Paul S, Hoey MF, Egbert JE. Pressure measurements during injection of corticosteroids: In vivo studies. Med Biol Eng Comput. 1999;37:645-651.
67. Dutton JJ. Arterial supply to the orbit. In: Clinical and Surgical Orbital Anatomy. Philadelphia, Pa: Saunders; 1994:68-71.
68. Badeer H. Hemodynamics for medical students. Adv Physiol Educ. 2001;25:44-52.
69. Zweifach BW. Quantitative studies of microcirculatory structure and function: I. Analysis of pressure distribution in the terminal vascular bed in cat mesentery. Circ Res. 1974;34: 843-857.
70. Zweifach BW. Quantitative studies of microcirculatory structure and function: II. Direct measurement of capillary pressure in splanchnic mesenteric vessels. Circ Res. 1974;34:858-866.
71. Bullock JD, Warwar RE, Green WR. Ocular explosion during cataract surgery: A clinical, histopathological, experimental, and biophysical study. Trans Am Ophthalmol Soc. 1998;96:243-276; discussion 276-281.
72. Hayreh SS. Vascular disorders in neuro-ophthalmology. Curr Opin Neurol. 2011;24:6-11.
73. Chen CS, Lee AW. Management of acute central retinal artery occlusion. Nat Clin Pract Neurol. 2008;4:376-383.
74. Hayreh SS, Weingeist TA. Experimental occlusion of the central artery of the retina: IV. Retinal tolerance time to acute ischaemia. Br J Ophthalmol. 1980;64:818-825.
75. Sellés-Navarro I, Villegas-Pérez MP, Salvador-Silva M, Ruiz-Gómez JM, Vidal-Sanz M. Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals: A quantitative in vivo study. Invest Ophthalmol Vis Sci. 1996;37:2002-2014.
76. Roth S, Li B, Rosenbaum PS, et al. Preconditioning provides complete protection against retinal ischemic injury in rats. Invest Ophthalmol Vis Sci. 1998;39:775-785.
77. Schumacher M, Schmidt D, Jurklies B, et al. Central retinal artery occlusion: Local intra-arterial fibrinolysis versus conservative treatment, a multicenter randomized trial. Ophthalmology 2010;117:1367-1375.e1.
78. McCleve DE, Goldstein JC. Blindness secondary to injections in the nose, mouth, and face: Cause and prevention. Ear Nose Throat J. 1995;74:182-188.
79. Ffytche TJ. A rationalization of treatment of central retinal artery occlusion. Trans Ophthalmol Soc UK. 1974;94:468-479.
80. Augsburger JJ, Magargal LE. Visual prognosis following treatment of acute central retinal artery obstruction. Br J Ophthalmol. 1980;64:913-917.
81. McGrew RN, Wilson RS, Havener WH. Sudden blindness secondary to injections of common drugs in the head and neck: II. Animal studies. Otolaryngology 1978;86:152-157.
82. Alm A, Bill A. Ocular circulation. In: Alder FH, Moses RA, Hart WM, eds. Adler's Physiology of the Eye. 8th ed. St. Louis: Mosby; 1987:183-203.
83. Hayreh SS. Prevalent misconceptions about acute retinal vascular occlusive disorders. Prog Retin Eye Res. 2005;24:493-519.
84. García-Arumí J, Martinez-Castillo V, Boixadera A, Fonollosa A, Corcostegui B. Surgical embolus removal in retinal artery occlusion. Br J Ophthalmol. 2006;90:1252-1255.
85. Hayreh SS. Surgical embolus removal in retinal artery occlusion. Br J Ophthalmol. 2007;91:1096-1097.
86. Opremcak EM, Benner JD. Translumenal Nd:YAG laser embolysis for branch retinal artery occlusion. Retina 2002;22: 213-216.
87. Tzikas TL. Facial fat injection. In: Thomas JR, ed. Advanced Therapy in Facial Plastic and Reconstructive Surgery. Shelton, Conn: People's Medical Publishing House; 2010:573-580.
88. Niamtu J III. Filler injection with micro-cannula instead of needles. Dermatol Surg. 2009;35:2005-2008.
89. Berlin A, Cohen JL, Goldberg DJ. Calcium hydroxylapatite for facial rejuvenation. Semin Cutan Med Surg. 2006;25:132-137.