Topical treatment of oral cavity and wounded skin with a new disinfection system utilizing photolysis of hydrogen peroxide in rats

Journal of Toxicological Sciences

Volumn 37, Issue 2, 2012, Pages 329-335

  Yamada, Yasutomo ^a   Mokudai, Takayuki ^a   Nakamura, Keisuke ^a   Hayashi, Eisei ^a   Kawana, Yoshiko ^b   Kanno, Taro ^a   Sasaki, Keiichi ^a   Niwano, Yoshimi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b AZ Co   (Japan)

Author keywords

Hydroxyl radical; Rats; Safety evaluation; Topical application

Indexed keywords

COLLAGEN; HYDROGEN PEROXIDE; HYDROXYL RADICAL;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DISINFECTION; DRUG SCREENING; EPIDERMIS; EPITHELIZATION; GRANULATION TISSUE; LOW LEVEL LASER THERAPY; MALE; MOUTH MUCOSA; NONHUMAN; PHOTOLYSIS; RAT; SKIN INJURY; STAPHYLOCOCCUS AUREUS; WOUND CARE;

RATTUS; STAPHYLOCOCCUS AUREUS;

EID: 84859303979     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.329     Document Type: Article

References (22)

1. Atrux-Tallau, N., Callejon, S., Migdal, C., Padois, K., Bertholle, V., Denis, A., Chavagnac-Bonneville, M., Haftek, M. and Falson, F. (2011): Development and in vitro assay of oxidative stress modifying formulations for wound healing promotion. Eur. J. Dermatol., 21, Suppl. 2, 52-62.
2. Buettner, G.R. (1987): Spin trapping: ESR parameters of spin adducts. Free Radic. Biol. Med., 3, 259-303.
3. Darley-Usmar, V. and Halliwell, B. (1996): Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm. Res., 13, 649-662.
4. Eligini, S., Arenaz, I., Barbieri, S.S., Faleri, M.L., Crisci, M., Tremoli, E. and Colli, S. (2009): Cyclooxygenase-2 mediates hydrogen peroxide-induced wound repair in human endothelial cells. Free Radic. Biol. Med., 46, 1428-1436.
5. FDA (2003): FR Doc 03-12783.
6. Fridovich, I. (1986): Biological effects of the superoxide radical. Arch. Biochem. Biophys., 247, 1-11.
7. Halliwell, B. (1996a): Free radicals, proteins and DNA: oxidative damage versus redox regulation. Biochem. Soc. Trans., 24, 1023-1027.
8. Halliwell, B. (1996b): Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. Free Radic. Res., 25, 57-74.
9. Halliwell, B. and Gutteridge, J.M. (1984): Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J., 219, 1-14.
10. Halliwell, B. and Gutteridge, J.M. (1986): Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch. Biochem. Biophys., 246, 501-514.
11. Ikai, H., Nakamura, K., Shirato, M., Kanno, T., Iwasawa, A., Sasaki, K., Niwano, Y. and Kohno, M. (2010): Photolysis of hydrogen peroxide, an effective disinfection system via hydroxyl radical formation. Antimicrob. Agents. Chemother., 54, 5086-5091.
12. Iwasawa, A., Saito, K., Mokudai, T., Kohno, M., Ozawa, T. and Niwano, Y. (2009): Fungicidal action of hydroxyl radicals generated by ultrasound in water. J. Clin. Biochem. Nutr., 45, 214-218.
13. Kohno, M., Mokudai, T., Ozawa, T. and Niwano, Y. (2011): Free radical formation from sonolysis of water in the presence of different gases. J. Clin. Biochem. Nutr., 49, 96-101.
14. Nakamura, K., Kanno, T., Mokudai, T., Iwasawa, A., Niwano, Y. and Kohno, M. (2010): Reevaluation of quantitative ESR spin trapping analysis of hydroxyl radical by applying sonolysis of water as a model system. Bull. Chem. Soc. Jpn., 83, 1037-1046.
15. Niwano, Y., Koga, H., Kanai, K., Hamaguchi, H. and Yamaguchi, H. (1996a): Wound healing effect of the new imidazole antimycotic lanoconazole in rats. Arzneimittelforschung, 46, 218-223.
16. Niwano, Y., Koga, H., Sakai, A., Kanai, K., Hamaguchi, H., Uchida, M. and Tachikawa, T. (1996b): Wound healing effect of malotilate in rats. Arzneimittelforschung, 46, 450-455.
17. Pan, Q., Qiu, W.Y., Huo, Y.N., Yao, Y.F. and Lou, M.F. (2011): Low levels of hydrogen peroxide stimulate corneal epithelial cell adhesion, migration, and wound healing. Invest. Ophthalmol. Vis. Sci., 52, 1723-1734.
18. Pryor, W.A. (1986): Oxy-radicals and related species: their formation, lifetimes, and reactions. Annu. Rev. Physiol., 48, 657-667.
19. Schreml, S., Landthaler, M., Schaferling, M. and Babilas, P. (2011): A new star on the H2O2rizon of wound healing? Exp. Dermatol., 20, 229-231.
20. Shirato, M., Ikai, H., Nakamura, K., Hayashi, E., Kanno, T., Sasaki, K., Kohno, M. and Niwano, Y. (2012): Synergistic Effect of Thermal Energy on Bactericidal Action of Photolysis of H2O2 in Relation to Acceleration of Hydroxyl Radical Generation. Antimicrob. Agents Chemother., 56, 295-301.
21. Sies, H., Stahl, W. and Sundquist, A.R. (1992): Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Ann. N Y Acad. Sci., 669, 7-20.
22. Slater, T.F. (1984): Free-radical mechanisms in tissue injury. Biochem. J., 222, 1-15.