Production of IL-10, TNF and IL-12 by Peripheral Blood Mononuclear Cells in Mexican Workers Exposed to a Mixture of Benzene-Toluene-Xylene

Archives of Medical Research

Volumn 43, Issue 1, 2012, Pages 51-57

  Haro García, Luis Cuauhtémoc ^a   Juárez Pérez, Cuauhtémoc Arturo ^b   Aguilar Madrid, Guadalupe ^b   Vélez Zamora, Nadia Mayola ^b   Muñoz Navarro, Sergio ^c   Chacón Salinas, Rommel ^d   González Bonilla, César Raúl ^b   Iturbe Haro, Claudia Rosa ^d   Estrada García, Iris ^d   Borja Aburto, Víctor Hugo ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c UNIVERSIDAD DE LA FRONTERA   (Chile)

^d INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Benzene Toluene Xylene; Cytokines; Immune response; Occupational exposure

Indexed keywords

BENZENE; INTERLEUKIN 10; INTERLEUKIN 12; TOLUENE; TUMOR NECROSIS FACTOR; XYLENE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; MALE; MEXICO; MULTIPLE LINEAR REGRESSION ANALYSIS; OCCUPATIONAL EXPOSURE; PAINT INDUSTRY; PERIPHERAL BLOOD MONONUCLEAR CELL; STATISTICAL SIGNIFICANCE; WORKER;

ADULT; AIR POLLUTANTS, OCCUPATIONAL; BENZENE; COMPLEX MIXTURES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INDUSTRY; INTERLEUKIN-10; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; LINEAR MODELS; LIPOPOLYSACCHARIDES; MALE; MEXICO; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PAINT; SOLVENTS; TOLUENE; TUMOR NECROSIS FACTOR-ALPHA; XYLENES;

EID: 84859260847     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2012.01.008     Document Type: Article

References (63)

1. U.S. Environmental Protection Agency (EPA) Toxicological review of benzene (non-cancer effects). Washington, DC; October 2002.
2. Collins J.J., Ireland B.K., Easterday P.A., et al. Evaluation of lymphopenia among workers with low-level benzene exposure and the utility of routine data collection. JOEM 1997, 3:232-237.
3. Chakroun R., Kaabachi N., Hedhili A., et al. Benzene exposure monitoring of Tunisian workers. JOEM 2002, 12:1173-1178.
4. Occupational Safety & Health Administration (OSHA) Substance safety data sheet, Benzene 1910.1028 App A.
5. Yin S.N., Li Q., Liu Y., et al. Occupational exposure to benzene in China. Br J Ind Med 1987, 44:192-195.
6. Qu Q., Shore R., Li G., et al. Hematological changes among Chinese workers with a broad range of benzene exposures. Am J Ind Med 2002, 42:275-285.
7. Bogadi-Sâre A., Zavalić M., Trošić I., et al. Study of some immunological parameters in workers occupationally exposed to benzene. Int Arch Occup Environ Health 2000, 73:397-400.
8. Mixed exposures research agenda. A report by the NORA mixed exposure team December 2004, Department of Health and Human Services, NIOSH, Cincinnati, OH, USA.
9. Interaction profile for: Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX) May 2004, Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services; Public Health Service.
10. Mendoza-Cantú A., Castorena-Torres F., Bermúdez-de Leon M., et al. Occupational toluene exposure induces cytochrome P450 2E1 mRNA expression in peripheral lymphocytes. Environ Health Perspect 2006, 114:494-499.
11. Korsak Z., Sokal J.A., Górny R. Toxic effects of combined exposures to toluene and m-xylene in animals. III. Subchronic inhalation study. Pol J Occup Med Environ Health 1992, 5:27-33.
12. Rhodes A.G., LeMasters G.K., Lockey J.E., et al. The effects of jet fuel on immune cells of fuel system maintenance workers. J Occup Environ Med 2003, 45:79-86.
13. Tanigawa T., Araki S., Nakata A., et al. Decreases of natural killer cells and T-lymphocyte subpopulations and increase of B lymphocytes following a 5-day occupational exposure to mixed organic solvents. Arch Environ Health 2001, 56:443-448.
14. Hernández-Urzúa M.A., Alvarado-Navarro A. Interleucinas e inmunidad innata. Rev Biomed 2001, 12:272-280.
15. Malefyt RW. IL-10. Department of Molecular Biology, DNAX Research Institute; Palo Alto, CA; USA; doi:16/1006/rwcy.2000.03.005.
16. Aggarwal BB, Samanta A, Feldmann M. TNF-a; Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA and Kennedy Institute of Rheumatology, London, UK 2000.
17. Esche C, Shurin MR, Lotze MT. IL-12. Biological Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA 2000.
18. Norma Oficial Mexicana NOM-174-SSA1-1998: Manejo integral de la obesidad.
19. Layton D.W. Metabolically consistent breathing rates for use in dose assessments. Health Phys 1993, 64:23-26.
20. Inhalation route. Chapter V. In: Woods P, Phillips L, Adenuga A, et al. Exposure Factors Handbook. US Environmental Protection Agency (EPA), 1997. pp. 5-7.
21. Aston J.P., Ball R.L., Pople J.E., et al. Development and validation of competitive immunoassay for urinary S-phenylmercapturic acid and its application in benzene biological monitoring. Biomarkers 2002, 7:103-112.
22. Szklo M., Nieto J. Epidemiology. Beyond the Basics 2004, Jones and Bartlett, Boston.
23. Ley General de Salud, Mexico. Latest amendment. Diario Oficial de la Federación; 19 Jun 2007; Reglamento de la Ley General de Salud en Materia de Investigación en Salud.
24. Doherty T.M., Ardite M. Innate immunity, toll-like receptors and host response to infection. Pediatr Infect Dis J 2005, 24:643-644.
25. Adeream A., Ulevitch R.J. Toll-like receptors in the induction of the innate immune response. Nature 2000, 406:782-787.
26. Boogard P.J., van Sittert N.J. Biological monitoring of exposure to benzene: a comparison between S-phenylmercapturic acid, trans, transmuconic acid, and phenol. Occup Environ Med 1995, 52:611-620.
27. Yanagawa Y., Onoé K. Enhanced IL-10 production by TLR-4 and TLR2-primed dendritic cells upon TLR restimulation. J Immunol 2007, 178:6173-6180.
28. Pecheco K.A., Sterritt T. The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-β and IL-1β. Clin Exp Immunol 2001, 126:374-383.
29. Luster M.I., Rosenthal G.J. Chemical agents and the immune response. Environ Health Perspect 1993, 100:219-236.
30. Lustr M.I., Wierda D., Rosenthal G.J. Environmentally related disorders of the hematologic and immune systems. Med Clin North Am 1990, 74:425-440.
31. Molls R.R., Ahluwalia N., Mastro A.M., et al. Nutritional status predicts primary subclasses of T cells and the lymphocyte proliferation response in healthy older women. J Nutr 2005, 135:2644-2650.
32. Kalra R., Singh P.S., Pena-Philippides J.C., et al. Immunosuppresive and anti-inflammatory effects of nicotine administered by patch in an animal model. Clin Diagn Lab Immunol 2004, 11:563-568.
33. Hogg N. Nicotine has suppressive effects on dendritic cell function. Immunology 2003, 109:329-330.
34. Dowling O., Rochelson B., Way K., et al. Nicotine inhibits cytokine production by placenta cells via NFκB: potential role in pregnancy-induced hypertension. Mol Med 2007, 13:576-583.
35. Laan M., Bozinovski S., Anderson G.P. Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells. J Immunol 2004, 173:4164-4170.
36. Churg A., Wang R.D., Tai H., et al. Tumor necrosis factor-α drives 70% of cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2004, 170:492-498.
37. Karimi K., Sarir H., Mortaz E., et al. Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages. Respir Res 2006, 7:66.
38. Chen J.D., Wang J.D., Jang J.P., et al. Exposure to mixtures of solvents among paint workers and biochemical alterations of liver function. Br J Ind Med 1991, 48:696-701.
39. Lorgeril M., Salen P. Is alcohol anti-inflammatory in the context of coronary heart disease?. Heart 2004, 90:355-357.
40. Jerrels T.R., Marrieta C.A., Eckardt M.J., et al. Effects of ethanol on parameters of immunocomptenecy in rats. J Leukoc Biol 1986, 39:499-510.
41. Szabo G. Consequences of alcohol consumption on host defence. Alcohol Alcohol 1999, 34:830-841.
42. Oak S., Mandrekar P., Catalano D., et al. TLR2 and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. J Immunol 2006, 176:7628-7635.
43. O'Rourke R.W., Kay T., Lyle E.A., et al. Alterations in peripheral blood lymphocyte cytokine expression in obesity. Clin Exp Immunol 2006, 146:39-46.
44. Manco M., Fernandez-Real J.M., Equitani F., et al. Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women. J Clin Endocrinol Metab 2007, 92:483-490.
45. Creely S.J. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 2007, 292:E740-E747.
46. Wisse B.E. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 2004, 15:2792-2800.
47. Sullivan K.E., Cutilli J., Piliero L.M., et al. Measurement of cytokine secretion, intracellular protein expression, and mRNA in resting and stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2000, 7:920-924.
48. Xing T., Li L., Cao H., et al. Altered immune function of monocytes in different stages of patients with acute on chronic liver failure. Clin Exp Immunol 2006, 147:184-188.
49. Drug discovery tools for immunotoxicology research. BD Biosciences Clontech Pharmingen BD; 2003. Available from: . http://www.bdj.co.jp/pdf/55-20_03-7900030-3-A1.pdf.
50. Food and Drug Administration. Center for Drug Evaluation and Research (CDER); Guidance for Industry. Immunotoxicology evaluation of investigational new drugs. US Department of Health and Human Services; October 2002.
51. Kyriakopolou M., Antonopoulo A., Raftogiannis M., et al. The importance of fever as a predictive symptom for the potency of host's monocytes to release pro- and anti-inflammatory mediators. Mediators Inflamm 2008, 2008:450196.
52. Haro-García L.C., González-Bonilla C.R., Chacón-Salinas R., et al. Manifestaciones hemato/inmunológicas asociadas a exposición ocupacional a mezcla de BTX (benceno-tolueno-xileno). Rev Med IMSS 2008, 46:643-650.
53. U.S. Environmental Protection Agency (EPA). Guidelines for Exposure Assessment. Risk Assessment Forum; Washington, DC; May 1992.
54. Crebelli R., Tomei F., Zijno A., et al. Exposure to benzene in urban workers: environmental and biological monitoring of traffic police in Rome. Occup Environ Med 2001, 58:165-171.
55. Vermeulen R., Li G., Lan Q., et al. Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China. Ann Occup Hyg 2004, 48:105-116.
56. Zeliger H.I. Toxic effects of chemical mixtures. Arch Environ Health 2003, 58:23-29.
57. Lan Q., Zhang L., Li G., et al. Hematotoxicity in workers exposed to low levels of benzene. Science 2004, 306:1774-1776.
58. Alexopoulos E.C., Chatzis C., Linos A. An analysis of factors that influence personal exposure to toluene and xylene in residents of Athens, Greece. BMC Public Health 2006, 6:50.
59. Khuder S.A., Youngdale M.C., Bisesir M.S., et al. Assessment of complete count variations among workers exposed to low levels of benzene. J Occup Environ Med 1999, 41:821-826.
60. Haider D.G., Leuchten N., Schaller G., et al. C-reactive protein is expressed and secreted by peripheral blood mononuclear cells. Clin Exp Immunol 2006, 146:533-539.
61. Kim B.H., Shin H.M., Jung S.H., et al. Anti-inflammatory benzene diamine compound inhibited toll-like receptor 4-mediated inducible nitric oxide synthase expression and nuclear factor-κB activation. Biol Pharm Bull 2005, 28:908-911.
62. Lan Q., Zhang L., Shen M., et al. Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. Cancer Res 2005, 65:9574-9581.
63. Foster J.R. The functions of cytokines and their uses in toxicology. Int J Exp Pathol 2001, 82:171-192.