Novel noninvasive detection of the fovea avascular zone using confocal red-free imaging in diabetic retinopathy and retinal vein occlusion

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 1, 2012, Pages 309-315

  Shin, Yong Un ^a   Kim, Sungmin ^b   Lee, Byung Ro ^a   Shin, Joong Won ^a   Kim, Sun I ^b,c  

^a Department of Biochemistry and Molecular Biology   (South Korea)

^b Hanyang University   (South Korea)

^c New Drug Development Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; COMPARATIVE STUDY; CONFOCAL RED FREE IMAGING; CROSS-SECTIONAL STUDY; DIABETIC RETINOPATHY; FEMALE; FLUORESCENCE ANGIOGRAPHY; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGING; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RETINA BLOOD VESSEL; RETINA FOVEA; RETINA VEIN OCCLUSION; RETROSPECTIVE STUDY; SCANNING LASER OPHTHALMOSCOPY; CAPILLARY; CONFOCAL MICROSCOPY; MIDDLE AGED; OPTICAL COHERENCE TOMOGRAPHY; PATHOLOGY; PATHOPHYSIOLOGY; VASCULARIZATION;

CAPILLARIES; CROSS-SECTIONAL STUDIES; DIABETIC RETINOPATHY; FEMALE; FLUORESCEIN ANGIOGRAPHY; FOVEA CENTRALIS; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; RETINAL VEIN OCCLUSION; RETINAL VESSELS; RETROSPECTIVE STUDIES; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84859244790     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8510     Document Type: Article

References (30)

1. Rogers SL, McIntosh RL, Lim L, et al. Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology. 2010;117:1094-1101.
2. Fong DS, Ferris FL 3rd, Davis MD, Chew EY. Causes of severe visual loss in the early treatment diabetic retinopathy study: ETDRS report no. 24. Early Treatment Diabetic Retinopathy Study Research Group. Am J Ophthalmol. 1999;127:137-141.
3. Bresnick GH, Condit R, Syrjala S, Palta M, Groo A, Korth K. Abnormalities of the foveal avascular zone in diabetic retinopathy. Arch Ophthalmol. 1984;102:1286-1293.
4. Arend O, Wolf S, Harris A, Reim M. The relationship of macular microcirculation to visual acuity in diabetic patients. Arch Ophthalmol. 1995;113:610-614.
5. Ryan SJ, ed. Retina. 4th ed. Los Angeles: Elsevier; 2006:541.
6. Mansour AM. Measuring fundus landmarks. Invest Ophthalmol Vis Sci. 1990;31:41-42.
7. Arend O, Wolf S, Jung F, et al. Retinal microcirculation in patients with diabetes mellitus: dynamic and morphological analysis of perifoveal capillary network. Br J Ophthalmol. 1991;75:514-518.
8. Lee SJ, Koh HJ. Enlargement of the foveal avascular zone in diabetic retinopathy after adjunctive intravitreal bevacizumab (avastin) with pars plana vitrectomy. J Ocul Pharmacol Ther. 2009;25: 173-174.
9. Classification of diabetic retinopathy from fluorescein angiograms. ETDRS report number 11. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991;98:807-822.
10. Mansour AM, Schachat A, Bodiford G, Haymond R. Foveal avascular zone in diabetes mellitus. Retina. 1993;13:125-128.
11. Bresnick GH, Davis MD, Myers FL, de Venecia G. Clinicopathologic correlations in diabetic retinopathy. II. Clinical and histologic appearances of retinal capillary microaneurysms. Arch Ophthalmol. 1977;95:1215-1220.
12. Sakata K, Funatsu H, Harino S, Noma H, Hori S. Relationship of macular microcirculation and retinal thickness with visual acuity in diabetic macular edema. Ophthalmology. 2007;114:2061-2069.
13. Parodi MB, Visintin F, Della Rupe P, Ravalico G. Foveal avascular zone in macular branch retinal vein occlusion. Int Ophthalmol. 1995;19:25-28.
14. Yannuzzi LA, Rohrer KT, Tindel LJ, et al. Fluorescein angiography complication survey. Ophthalmology. 1986;93:611-617.
15. Conrath J, Valat O, Giorgi R, et al. Semi-automated detection of the foveal avascular zone in fluorescein angiograms in diabetes mellitus. Clin Exp Ophthalmol. 2006;34:119-123.
16. Goldberg RE, Varma R, Spaeth GL, Magargal LE, Callen D. Quantification of progressive diabetic macular nonperfusion. Ophthalmic Surg. 1989;20:42-45.
17. Phillips RP, Spencer T, Ross PG, Sharp PF, Forrester JV. Quantification of diabetic maculopathy by digital imaging of the fundus. Eye. 1991;5:130-137.
18. Zheng Y, Gandhi JS, Stangos AN, Campa C, Broadbent DM, Harding SP. Automated segmentation of foveal avascular zone in fundus fluorescein angiography. Invest Ophthalmol Vis Sci. 2010;51: 3653-3659.
19. Conrath J, Giorgi R, Raccah D, Ridings B. Foveal avascular zone in diabetic retinopathy: quantitative vs qualitative assessment. Eye. 2004;19:322-326.
20. Applegate RA, Bradley A, van Heuven WA, Lee BL, Garcia CA. Entoptic evaluation of diabetic retinopathy. Invest Ophthalmol Vis Sci. 1997;38:783-791.
21. Popovic Z, Knutsson P, Thaung J, Owner-Petersen M, Sjöstrand J. Noninvasive imaging of human foveal capillary network using dual-conjugate adaptive optics. Invest Ophthalmol Vis Sci. 2011; 52:2649-2655.
22. Martin JA, Roorda A. Direct and noninvasive assessment of parafoveal capillary leukocyte velocity. Ophthalmology. 2005;112: 2219-2224.
23. Loukovaara S, Harju M, Immonen I. Macular blood flow measured by blue-field entoptoscopy and Heidelberg retinal flowmetry: comparison of two techniques in type 1 diabetes women during pregnancy. Acta Ophthalmol (Copenh). 2009;87:506-510.
24. Tam J, Martin JA, Roorda A. Noninvasive visualization and analysis of parafoveal capillaries in humans. Invest Ophthalmol Vis Sci. 2010;51:1691-1698.
25. Peli E, Hedges TR 3rd, McInnes T, Hamlin J, Schwartz B. Nerve fiber layer photography. A comparative study. Acta Ophthalmol (Copenh). 1987;65:71-80.
26. Woon WH, Fitzke FW, Bird AC, Marshall J. Confocal imaging of the fundus using a scanning laser ophthalmoscope. Br J Ophthalmol. 1992;76:470-474.
27. Chylack LT Jr, Wolfe JK, Singer DM, et al. The lens opacities classification system III. The Longitudinal Study of Cataract Study Group. Arch Ophthalmol. 1993;111:831-836.
28. Behrendt T, Wilson LA. Spectral reflectance photography of the retina. Am J Ophthalmol. 1965;59:1079-1088.
29. Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991;98:823-833.
30. Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study Research Group. Arch Ophthalmol. 1985;103:1796-1806.