Long time to diagnosis of medulloblastoma in children is not associated with decreased survival or with worse neurological outcome

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Brasme, Jean Francois ^a,b,c   Grill, Jacques ^a,b   Doz, Francois ^d,e   Lacour, Brigitte ^f   Valteau Couanet, Dominique ^a,b   Gaillard, Stephan ^g,h   Delalande, Olivier ⁱ   Aghakhani, Nozar ^b,j   Puget, Stéphanie ^e,k   Chalumeau, Martin ^c,e,k  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c HÔPITAL SAINT VINCENT DE PAUL   (France)

^d INSTITUT CURIE   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f UNIVERSITY HOSPITAL OF NANCY   (France)

^g FOCH HOSPITAL   (France)

^h University of Paris Ile de France Ouest   (France)

ⁱ FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD   (France)

^j BICÊTRE HOSPITAL   (France)

^k HÔPITAL NECKER ENFANTS MALADES   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ARTICLE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DELAYED DIAGNOSIS; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; FEMALE; FRANCE; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; MULTIVARIATE ANALYSIS; NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; POPULATION BASED CASE CONTROL STUDY; PRESCHOOL CHILD; RETROSPECTIVE STUDY; SCHOOL CHILD; TUMOR VOLUME; UNIVARIATE ANALYSIS; CEREBELLUM TUMOR; INTELLIGENCE TEST; KAPLAN MEIER METHOD; MALPRACTICE; MORTALITY; PROPORTIONAL HAZARDS MODEL; STATISTICAL MODEL; TREATMENT OUTCOME;

CEREBELLAR NEOPLASMS; CHILD; CHILD, PRESCHOOL; DELAYED DIAGNOSIS; HUMANS; INTELLIGENCE TESTS; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; MALPRACTICE; MEDULLOBLASTOMA; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; TUMOR BURDEN;

EID: 84859242333     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033415     Document Type: Article

References (40)

1. Desandes E, Clavel J, Berger C, Bernard JL, Blouin P, et al. (2004) Cancer incidence among children in France, 1990-1999. Pediatr Blood Cancer 43: 749-757.
2. Desandes E, Berger C, Tron I, Demeocq F, Bellec S, et al. (2008) Childhood cancer survival in France, 1990-1999. Eur J Cancer 44: 205-215.
3. Verlooy J, Mosseri V, Bracard S, Tubiana AL, Kalifa C, et al. (2006) Treatment of high risk medulloblastomas in children above the age of 3 years: a SFOP study. Eur J Cancer 42: 3004-3014.
4. Grill J, Sainte-Rose C, Jouvet A, Gentet JC, Lejars O, et al. (2005) Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children. Lancet Oncol 6: 573-580.
5. Oyharcabal-Bourden V, Kalifa C, Gentet JC, Frappaz D, Edan C, et al. (2005) Standard-risk medulloblastoma treated by adjuvant chemotherapy followed by reduced-dose craniospinal radiation therapy: a French Society of Pediatric Oncology Study. J Clin Oncol 23: 4726-4734.
6. Grill J, Renaux VK, Bulteau C, Viguier D, Levy-Piebois C, et al. (1999) Long-term intellectual outcome in children with posterior fossa tumors according to radiation doses and volumes. Int J Radiat Oncol Biol Phys 45: 137-145.
7. Frange P, Alapetite C, Gaboriaud G, Bours D, Zucker JM, et al. (2009) From childhood to adulthood: long-term outcome of medulloblastoma patients. The Institut Curie experience (1980-2000). J Neurooncol 95: 271-279.
8. Reulecke BC, Erker CG, Fiedler BJ, Niederstadt TU, Kurlemann G, (2008) Brain tumors in children: initial symptoms and their influence on the time span between symptom onset and diagnosis. J Child Neurol 23: 178-183.
9. Haimi M, Peretz Nahum M, Ben Arush MW, (2004) Delay in diagnosis of children with cancer: a retrospective study of 315 children. Pediatr Hematol Oncol 21: 37-48.
10. Pollock BH, Krischer JP, Vietti TJ, (1991) Interval between symptom onset and diagnosis of pediatric solid tumors. J Pediatr 119: 725-732.
11. Saha V, Love S, Eden T, Micallef-Eynaud P, MacKinlay G, (1993) Determinants of symptom interval in childhood cancer. Arch Dis Child 68: 771-774.
12. Thulesius H, Pola J, Hakansson A, (2000) Diagnostic delay in pediatric malignancies-a population-based study. Acta Oncol 39: 873-876.
13. Halperin EC, Watson DM, George SL, (2001) Duration of symptoms prior to diagnosis is related inversely to presenting disease stage in children with medulloblastoma. Cancer 91: 1444-1450.
14. Flores LE, Williams DL, Bell BA, O'Brien M, Ragab AH, (1986) Delay in the diagnosis of pediatric brain tumors. Am J Dis Child 140: 684-686.
15. Dobrovoljac M, Hengartner H, Boltshauser E, Grotzer MA, (2002) Delay in the diagnosis of paediatric brain tumours. Eur J Pediatr 161: 663-667.
16. Mehta V, Chapman A, McNeely PD, Walling S, Howes WJ, (2002) Latency between symptom onset and diagnosis of pediatric brain tumors: an Eastern Canadian geographic study. Neurosurgery 51: 365-372; discussion 372-363.
17. Kukal K, Dobrovoljac M, Boltshauser E, Ammann RA, Grotzer MA, (2009) Does diagnostic delay result in decreased survival in paediatric brain tumours? Eur J Pediatr 168: 303-310.
18. Dang-Tan T, Franco EL, (2007) Diagnosis delays in childhood cancer: a review. Cancer 110: 703-713.
19. Wilne SH, Ferris RC, Nathwani A, Kennedy CR, (2006) The presenting features of brain tumours: a review of 200 cases. Arch Dis Child 91: 502-506.
20. Keene DL, Hsu E, Ventureyra E, (1999) Brain tumors in childhood and adolescence. Pediatr Neurol 20: 198-203.
21. Loh AH, Ha C, Chua JH, Seow WT, Chan MY, et al. (2009) Delays in diagnosis of pediatric solid tumors in Singapore. J Pediatr Hematol Oncol 31: 734-738.
22. Klein-Geltink J, Pogany L, Mery LS, Barr RD, Greenberg ML, (2006) Impact of age and diagnosis on waiting times between important healthcare events among children 0 to 19 years cared for in pediatric units: the Canadian Childhood Cancer Surveillance and Control Program. J Pediatr Hematol Oncol 28: 433-439.
23. Edgeworth J, Bullock P, Bailey A, Gallagher A, Crouchman M, (1996) Why are brain tumours still being missed? Arch Dis Child 74: 148-151.
24. Dang-Tan T, Trottier H, Mery LS, Morrison HI, Barr RD, et al. (2008) Delays in diagnosis and treatment among children and adolescents with cancer in Canada. Pediatr Blood Cancer 51: 468-474.
25. Brasme JF, Chalumeau M, Doz F, Lacour B, Valteau-Couanet D, et al. (2011) Interval between onset of symptoms and diagnosis of medulloblastoma in children: distribution and determinants in a population-based study. Eur J Pediatr 171: 25-32.
26. Dixon-Woods M, Findlay M, Young B, Cox H, Heney D, (2001) Parents' accounts of obtaining a diagnosis of childhood cancer. Lancet 357: 670-674.
27. Hoven E, Anclair M, Samuelsson U, Kogner P, Boman KK, (2008) The influence of pediatric cancer diagnosis and illness complication factors on parental distress. J Pediatr Hematol Oncol 30: 807-814.
28. Najaf-Zadeh A, Dubos F, Pruvost I, Bons-Letouzey C, Amalberti R, et al. (2010) Epidemiology and aetiology of paediatric malpractice claims in France. Arch Dis Child 96: 127-130.
29. Sommelet D, Clavel J, Lacour B, (2005) [Contribution of national paediatric cancer registries to survey and research]. Arch Pediatr 12: 814-816.
30. Lacour B, Guyot-Goubin A, Guissou S, Bellec S, Desandes E, et al. (2010) Incidence of childhood cancer in France: National Children Cancer Registries, 2000-2004. Eur J Cancer Prev 19: 173-181.
31. Kleihues P, Burger PC, Scheithauer BW, (1993) The new WHO classification of brain tumours. Brain Pathol 3: 255-268.
32. Kleihues P, Sobin LH, (2000) World Health Organization classification of tumors. Cancer 88: 2887.
33. Chang CH, Housepian EM, Herbert C Jr, (1969) An operative staging system and a megavoltage radiotherapeutic technic for cerebellar medulloblastomas. Radiology 93: 1351-1359.
34. Harisiadis L, Chang CH, (1977) Medulloblastoma in children: a correlation between staging and results of treatment. Int J Radiat Oncol Biol Phys 2: 833-841.
35. Lannering B, Rutkowski S, Doz F, Pizer B, Gustafsson G, et al. (2010) HIT- SIOP PNET4- A randomised multicentre study of hyperfractionated versus standard radiotherapy in children with standard risk medulloblastoma. Pediatr Blood Cancer 55: abstract O78.
36. Dufour C, Couanet D, Figarella-Branger D, Carrie C, Doz F, et al. (2008) Sequential high-dose chemotherapy with autologous stem cell rescue for children with high-risk medulloblastoma and supratentorial primitive neuroectodermal tumors. Neuro-Oncology 10: 488 (abstract).
37. Dufour C, Couanet D, Figarella-Branger D, Carrie C, Doz F, et al. (2008) Sequential high-dose chemotherapy and reducued craniospinal irradiation in young children with metastatic medulloblastoma. Neuro-Oncology 10: 423 (abstract).
38. D'Agostino RB Jr, (2007) Propensity scores in cardiovascular research. Circulation 115: 2340-2343.
39. Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, et al. (2011) Medulloblastoma Comprises Four Distinct Molecular Variants. J Clin Oncol: 29 (11): 1408-1414.
40. Alston RD, Newton R, Kelsey A, Newbould MJ, Birch JM, et al. (2003) Childhood medulloblastoma in northwest England 1954 to 1997: incidence and survival. Dev Med Child Neurol 45: 308-314.