Pseudomonas aeruginosa keratitis: Outcomes and response to corticosteroid treatment

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 1, 2012, Pages 267-272

  Sy, Aileen ^a   Srinivasan, Muthiah ^b   Mascarenhas, Jeena ^b   Lalitha, Prajna ^b   Rajaraman, Revathi ^b   Ravindran, Meenakshi ^b   Oldenburg, Catherine E ^a   Ray, Kathryn J ^a   Glidden, David ^a   Zegans, Michael E ^c   McLeod, Stephen D ^a   Lietman, Thomas M ^a   Acharya, Nisha R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ARAVIND EYE CARE SYSTEM   (India)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOXIFLOXACIN; PLACEBO; PREDNISOLONE 21 PHOSPHATE; ANTIINFECTIVE AGENT; DRUG DERIVATIVE; GLUCOCORTICOID; HETEROCYCLIC COMPOUND; PREDNISOLONE; QUINOLINE DERIVATIVE;

ADULT; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CORNEA PERFORATION; CORNEA ULCER; DEATH; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; INTRAOCULAR PRESSURE; KERATITIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SIDE EFFECT; SKIN DEFECT; TREATMENT OUTCOME; VISUAL ACUITY; BACTERIAL EYE INFECTION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PSEUDOMONAS INFECTION;

ADULT; ANTI-INFECTIVE AGENTS; AZA COMPOUNDS; CORNEAL ULCER; DOUBLE-BLIND METHOD; EYE INFECTIONS, BACTERIAL; FEMALE; FOLLOW-UP STUDIES; GLUCOCORTICOIDS; HUMANS; MALE; MIDDLE AGED; PREDNISOLONE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUINOLINES; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 84859239646     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7840     Document Type: Article

References (24)

1. American Academy of Ophthalmology Cornea/External Disease Panel. Bacterial Keratitis: Preferred Practice Pattern. American Academy of Ophthalmology. 2000:1-22.
2. Bharathi MJ, Ramakrishnan R, Meenakshi R, Padmavathy S, Shivakumar C, Srinivasan M. Microbial keratitis in South India: influence of risk factors, climate, and geographical variation. Ophthalmic Epidemiol. 2007;14:61-69.
3. Bharathi MJ, Ramakrishnan R, Shivakumar C, Meenakshi R, Lionalraj D. Etiology and antibacterial susceptibility pattern of community-acquired bacterial ocular infections in a tertiary eye care hospital in South India. Indian J Ophthalmol. 2010;58:497-507.
4. Bharathi MJ, Ramakrishnan R, Vasu S, Palaniappan R. Aetiological diagnosis of microbial keratitis in South India-a study of 1618 cases. Indian J Med Microbiol. 2002;20:19-24.
5. Forster RK. Conrad Berens Lecture: the management of infectious keratitis as we approach the 21st century. CLAO J. 1998;24:175-180.
6. Srinivasan M, Gonzales CA, George C, et al. Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, South India. Br J Ophthalmol. 1997;81:965-971.
7. Varaprasathan G, Miller K, Lietman T, et al. Trends in the etiology of infectious corneal ulcers at the F. I. Proctor Foundation. Cornea. 2004;23:360-364.
8. Green M, Apel A, Stapleton F. Risk factors and causative organisms in microbial keratitis. Cornea. 2008;27:22-27.
9. Krachmer JH, Mannis MJ, Holland EJ. Cornea. 1st ed. St. Louis: Mosby; 1997:1139-1189.
10. Pepose JS, Holland GN, Wilhelmus KR. Ocular Infection and Immunity. 1st ed. St. Louis: Mosby; 1996:970-1031.
11. Badenoch PR, Hay GJ, McDonald PJ, Coster DJ. A rat model of bacterial keratitis: effect of antibiotics and corticosteroid. Arch Ophthalmol. 1985;103:718-722.
12. Gritz DC, Kwitko S, Trousdale MD, Gonzalez VH, McDonnell PJ. Recurrence of microbial keratitis concomitant with antiinflammatory treatment in an animal model. Cornea. 1992;11:404-408.
13. Cohen EJ. The case against the use of steroids in the treatment of bacterial keratitis. Arch Ophthalmol. 2009;127:103-104.
14. Hindman HB, Patel SB, Jun AS. Rationale for adjunctive topical corticosteroids in bacterial keratitis. Arch Ophthalmol. 2009;127: 97-102.
15. Blair J, Hodge W, Al-Ghamdi S, et al. Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: double-blinded randomized clinical trial. Can J Ophthalmol. 2011;46:40-45.
16. Carmichael TR, Gelfand Y, Welsh NH. Topical steroids in the treatment of central and paracentral corneal ulcers. Br J Ophthalmol. 1990;74:528-531.
17. Srinivasan M, Lalitha P, Mahalakshmi R, et al. Corticosteroids for bacterial corneal ulcers. Br J Ophthalmol. 2009;93:198-202.
18. Srinivasan M, Mascarenhas J, Rajaraman R, et al. Corticosteroids for bacterial keratitis: The Steroids for Corneal Ulcers Trial (SCUT). Arch Ophthalmol. 2011 Oct 10. [Epub ahead of print].
19. Srinivasan M, Mascarenhas J, Rajaraman R, et al. The Steroids for Corneal Ulcers Trial: study design and baseline characteristics. Arch Ophthalmol. 2011 Oct 10. [Epub ahead of print].
20. Leibowitz HM, Kupferman A. Anti-inflammatory effectiveness in the cornea of topically administered prednisolone. Invest Ophthalmol. 1974;13:757-763.
21. Kupferman A, Leibowitz HM. Anti-inflammatory effectiveness of topically administered corticosteroids in the cornea without epithelium. Invest Ophthalmol. 1975;14:252-255.
22. Wilhelmus KR. Indecision about corticosteroids for bacterial keratitis: an evidence-based update. Ophthalmology. 2002;109: 835-842, quiz 843.
23. Hobden JA, Engel LS, Hill JM, Callegan MC, O'Callaghan RJ. Prednisolone acetate or prednisolone phosphate concurrently administered with ciprofloxacin for the therapy of experimental Pseudomonas aeruginosa keratitis. Curr Eye Res. 1993;12:469-473.
24. Engel LS, Callegan MC, Hobden JA, Reidy JJ, Hill JM, O'Callaghan RJ. Effectiveness of specific antibiotic/steroid combinations for therapy of experimental Pseudomonas aeruginosa keratitis. Curr Eye Res. 1995;14:229-234.