Romiplostim for the early management of severe immune thrombocytopenia unresponsive to conventional treatment

British Journal of Haematology

Volumn 157, Issue 2, 2012, Pages 256-258

  Tagariello, Giuseppe ^a   Sartori, Roberto ^a   Radossi, Paolo ^a   Maschio, Nilla ^a   Risato, Renzo ^a   Stasi, Roberto ^b  

^a Castelfranco Veneto Hospital   (Italy)

^b ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

Immune thrombocytopenia; Platelets; Romiplostim; Thrombopoietin receptor agonists

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LOW MOLECULAR WEIGHT HEPARIN; PREDNISONE; ROMIPLOSTIM;

AGED; ANEMIA; ANTIBODY DETECTION; AUTOIMMUNE THROMBOCYTOPENIA; BLEEDING; BLOOD ANALYSIS; BONE MARROW BIOPSY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DEEP VEIN THROMBOSIS; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; EARLY INTERVENTION; ECCHYMOSIS; ERYTHROCYTE TRANSFUSION; FEMALE; HEADACHE; HUMAN; HUMAN TISSUE; LETTER; MEGAKARYOCYTE; MELENA; OUTCOME ASSESSMENT; PETECHIA; PRIORITY JOURNAL; SUBDURAL HEMATOMA; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; TREATMENT DURATION; TREATMENT RESPONSE;

AGED, 80 AND OVER; FEMALE; HUMANS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECEPTORS, FC; RECOMBINANT FUSION PROTEINS; SEVERITY OF ILLNESS INDEX; THROMBOPOIETIN;

EID: 84859216391     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08950.x     Document Type: Letter

References (9)

1. Bussel, J.B., Provan, D., Shamsi, T., Cheng, G., Psaila, B., Kovaleva, L., Salama, A., Jenkins, J.M., Roychowdhury, D., Mayer, B., Stone, N. & Arning, M. (2009) Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. Lancet, 373, 641-648.
2. Gernsheimer, T.B., George, J.N., Aledort, L.M., Tarantino, M.D., Sunkar, U., Matthew Guo, D. & Nichol, J.L. (2010) Evaluation of bleeding and thrombotic events during long-term use of romiplostim in patients with chronic immune thrombocytopenia (ITP). Journal Thrombosis & Haemostasis, 8, 1372-1382.
3. Kojouri, K., Vesely, S.K., Terrell, D.R. & George, J.N. (2004) Splenectomy for adult patients with idiopathic thrombocytopenic purpura:a systematic review to assess long term platelet count responses, prediction of response, and surgical complications. Blood, 104, 2623-2634.
4. Kuter, D.J., Bussel, J.B., Lyons, R.M., Pullarkat, V., Gernsheimer, T.B., Senecal, F.M., Aledort, L.M., George, J.N., Kessler, C.M., Sanz, M.A., Liebman, H.A., Slovick, F.T., de Wolf, J.T., Bourgeois, E., Guthrie, T.H., Jr, Newland, A., Wasser, J.S., Hamburg, S.I., Grande, C., Lefrère, F., Lichtin, A.E., Tarantino, M.D., Terebelo, H.R., Viallard, J.F., Cuevas, F.J., Go, R.S., Henry, D.H., Redner, R.L., Rice, L., Schipperus, M.R., Guo, D.M. & Nichol, J.L. (2008) Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet, 37, 95-403.
5. Kuter, D.J., Rummel, M., Boccia, R., Macik, B.G., Pabinger, I., Selleslag, D., Rodeghiero, F., Chong, B.H., Wang, X. & Berger, D.P. (2010) Romiplostim or standard of care in patients with immune thrombocytopenia. New England Journal of Medicine, 363, 1889-1899.
6. Newland, A. (2011) The diagnosis and management of chronic immune thrombocytopenia in adults. Hematology: The Education Programme for the Annual Congress of the EHA, 5, 184-190.
7. Provan, D., Stasi, R., Newland, A.C., Blanchette, V.S., Bolton-Maggs, P., Bussel, J.B., Chong, B.H., Cines, D.B., Gernsheimer, T.B., Godeau, B., Grainger, J., Greer, I., Hunt, B.J., Imbach, P.A., Lyons, G., McMillan, R., Rodeghiero, F., Sanz, M.A., Tarantino, M., Watson, S., Young, J. & Kuter, D.J. (2010) International consensus report on the investigationand management of primary immune thrombocytopenia. Blood, 115, 168-186.
8. Stasi, R., Evangelista, M.L., Stipa, E., Buccisano, F., Venditti, A. & Amadori, S. (2008) Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. Thrombosis & Haemostasis, 99, 4-13.
9. Zaja, F., Baccarani, M., Mazza, P., Bocchia, M., Gugliotta, L., Zaccaria, A., Vianelli, N., Defina, M., Tieghi, A., Amadori, S., Campagna, S., Ferrara, F., Angelucci, E., Usala, E., Cantoni, S., Visani, G., Fornaro, A., Rizzi, R., De Stefano, V., Casulli, F., Battista, M.L., Isola, M., Soldano, F., Gamba, E. & Fanin, R. (2010) Dexamethasone plus rituximab yields higher sustained response rates than dexamethasone monotherapy in adults with primary immune thrombocytopenia. Blood, 115, 2755-2762.