Neuronal activation and insight into the plasticity of DNA methylation

Epigenomics

Volumn 4, Issue 2, 2012, Pages 125-127

  Felling, Ryan J ^a   Guo, Junjie U ^a   Song, Hongjun ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

demethylation; epigenetic; Gadd45; learning; neurogenesis

Indexed keywords

5 METHYLCYTOSINE; BRAIN DERIVED NEUROTROPHIC FACTOR; DNA BASE; GENOMIC DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45;

BRAIN REGION; CELL DIFFERENTIATION; CELL POPULATION; CPG ISLAND; DENTATE GYRUS; DNA METHYLATION; DNA MODIFICATION; EDITORIAL; ELECTROCONVULSIVE THERAPY; EPIGENETICS; EXCISION REPAIR; GENE EXPRESSION; GENE LOCUS; HIPPOCAMPUS; HISTONE MODIFICATION; HUMAN; LEARNING; MEMORY; MOLECULAR MECHANICS; NERVE CELL PLASTICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

DNA METHYLATION; EPIGENOMICS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROGENESIS; NEURONS;

EID: 84859197859     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.12.2     Document Type: Editorial

References (20)

1. Johnson TB, Coghill RD. Researches on pyrimidines. C111. The discovery of 5methyl-cytosine in tuberculinic acid, the nucleic acid of the tubercle bacillus1. J. Am. Chem. Soc. 47(11), 2838-5682 (1925).
2. Hotchkiss RD. The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography. J. Biol. Chem. 175(1), 315-332 (1948).
3. Wyatt G. Recognition and estimation of 5methylcytosine in nucleic acids. Biochem. J. 48(5), 581-585 (1951).
4. Holliday R, Pugh JE. DNA modification mechanisms and gene activity during development. Science 187(4173), 226-232 (1975).
5. Morgan H, Santos F, Green K, Dean W, Reik W. Epigenetic reprogramming in mammals. Hum. Mol. Genet. 14(1), R47-R58 (2005).
6. Ooi S, Bestor T. The colorful history of active DNA demethylation. Cell 133(7), 1145-1153 (2008).
7. Zhang TY, Meaney MJ. Epigenetics and the environmental regulation of the genome and its function. Annu. Rev. Psychol. 61, 439-466 (2010).
8. Siegmund KD, Connor CM, Campan M et al. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS ONE 2(9), e895 (2007).
9. Martin GM. Epigenetic drift in aging identical twins. Proc. Natl Acad. Sci. USA 102(30), 10413-10414 (2005).
10. Day J, Sweatt J. DNA methylation and memory formation. Nat. Neurosci. 13(11), 1319-1342 (2010).
11. Miller C, Sweatt J. Covalent modification of DNA regulates memory formation. Neuron 53(6), 857-926 (2007).
12. Miller C, Gavin C, White J et al. Cortical DNA methylation maintains remote memory. Nat. Neurosci. 13(6), 664-670 (2010).
13. Madsen T, Treschow A, Bengzon J, Bolwig T, Lindvall O, Tingström A. Increased neurogenesis in a model of electroconvulsive therapy. Biol. Psychiat. 47(12), 1043-1052 (2000).
14. Ma D, Jang MH, Guo J et al. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (NY) 323(5917), 1074-1081 (2009).
15. Ma D, Guo J, Ming GL, Song H. DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle 8(10), 1526-1557 (2009).
16. Guo J, Su Y, Zhong C, Ming GL, Song H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145(3), 423-457 (2011).
17. Guo J, Ma D, Mo H et al. Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat. Neurosci. 14(10), 1345-1396 (2011).
18. Garbett K, Ebert PJ, Mitchell A et al. Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiol. Dis. 30, 303-311 (2008).
19. Matrisciano F, Dong E, Gavin D, Nicoletti F, Guidotti A. Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain. Mol. Pharmacol. 80(1), 174-256 (2011).
20. Kobow K, Blümcke I. The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis? Epilepsia 52(Suppl. 4), 15-19 (2011).