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Volumn 70, Issue 1, 2012, Pages 30-38

Metabolite analyses of single cells

Author keywords

mass spectrometry; metabolite detection; metabolite imaging; metabolomics; single cell analysis; single cell separation

Indexed keywords

BIOLOGICAL MECHANISMS; CELLULAR PHYSIOLOGY; DETECTION SENSITIVITY; GENOMIC INFORMATION; METABOLITE ANALYSIS; METABOLOMICS; MULTICELLULAR ORGANISMS; SINGLE CELLS; SINGLECELL ANALYSIS; SMALL SIZE;

EID: 84859151472     PISSN: 09607412     EISSN: 1365313X     Source Type: Journal    
DOI: 10.1111/j.1365-313X.2012.04967.x     Document Type: Review
Times cited : (66)

References (88)
  • 1
    • 77956939507 scopus 로고    scopus 로고
    • Analytical techniques for single-cell metabolomics: State of the art and trends
    • Amantonico, A., Urban, P.L., and, Zenobi, R., (2010a) Analytical techniques for single-cell metabolomics: state of the art and trends. Anal. Bioanal. Chem. 398, 2493-2504.
    • (2010) Anal. Bioanal. Chem. , vol.398 , pp. 2493-2504
    • Amantonico, A.1    Urban, P.L.2    Zenobi, R.3
  • 2
    • 77956253776 scopus 로고    scopus 로고
    • Single-cell MALDI-MS as an analytical tool for studying intrapopulation metabolic heterogeneity of unicellular organisms
    • Amantonico, A., Urban, P.L., Fagerer, S.R., Balabin, R.M., and, Zenobi, R., (2010b) Single-cell MALDI-MS as an analytical tool for studying intrapopulation metabolic heterogeneity of unicellular organisms. Anal. Chem. 82, 7394-7400.
    • (2010) Anal. Chem. , vol.82 , pp. 7394-7400
    • Amantonico, A.1    Urban, P.L.2    Fagerer, S.R.3    Balabin, R.M.4    Zenobi, R.5
  • 3
    • 0037170789 scopus 로고    scopus 로고
    • Detection of doxorubicin and metabolites in cell extracts and in single cells by capillary electrophoresis with laser-induced fluorescence detection
    • Anderson, A.B., Gergen, J., and, Arriaga, E.A., (2002) Detection of doxorubicin and metabolites in cell extracts and in single cells by capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. B, 769, 97-106.
    • (2002) J. Chromatogr. B , vol.769 , pp. 97-106
    • Anderson, A.B.1    Gergen, J.2    Arriaga, E.A.3
  • 5
    • 59349118696 scopus 로고    scopus 로고
    • A genetically encoded fluorescent reporter of ATP:ADP ratio
    • Berg, J., Hung, Y.P., and, Yellen, G., (2009) A genetically encoded fluorescent reporter of ATP:ADP ratio. Nat. Methods, 6, 161-166.
    • (2009) Nat. Methods , vol.6 , pp. 161-166
    • Berg, J.1    Hung, Y.P.2    Yellen, G.3
  • 7
    • 15944379241 scopus 로고    scopus 로고
    • Image analysis and in vivo imaging as tools for investigation of productivity dynamics in anthocyanin-producing cell cultures of Daucus carota
    • Ceoldo, S., Levi, M., Marconi, A.M., Baldan, G., Giarola, M., and, Guzzo, F., (2005) Image analysis and in vivo imaging as tools for investigation of productivity dynamics in anthocyanin-producing cell cultures of Daucus carota. New Phytol. 166, 339-352.
    • (2005) New Phytol. , vol.166 , pp. 339-352
    • Ceoldo, S.1    Levi, M.2    Marconi, A.M.3    Baldan, G.4    Giarola, M.5    Guzzo, F.6
  • 8
    • 70449344685 scopus 로고    scopus 로고
    • Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells
    • Chan, E.M., Ratanasirintrawoot, S., Park, I.H., et al. (2009) Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat. Biotechnol. 27, 1033-1037.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 1033-1037
    • Chan, E.M.1    Ratanasirintrawoot, S.2    Park, I.H.3
  • 9
    • 0029644301 scopus 로고
    • Determination of catecholamines in single adrenal medullary cells by capillary electrophoresis and laser-induced native fluorescence
    • Chang, H.T., and, Yeung, E.S., (1995) Determination of catecholamines in single adrenal medullary cells by capillary electrophoresis and laser-induced native fluorescence. Anal. Chem. 67, 1079-1083.
    • (1995) Anal. Chem. , vol.67 , pp. 1079-1083
    • Chang, H.T.1    Yeung, E.S.2
  • 10
    • 28644449198 scopus 로고    scopus 로고
    • Analysis of amino acids in individual wheat embryonic protplast
    • Chen, F.G., Wang, C., Zhi, D.Y., and, Xia, G.M., (2005) Analysis of amino acids in individual wheat embryonic protplast. Amino Acids, 29, 235-239.
    • (2005) Amino Acids , vol.29 , pp. 235-239
    • Chen, F.G.1    Wang, C.2    Zhi, D.Y.3    Xia, G.M.4
  • 14
    • 0029832083 scopus 로고    scopus 로고
    • Flow cytometry and cell sorting of heterogeneous microbial populations: The importance of single-cell analyses
    • Davey, H.M., and, Kell, D.B., (1996) Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses. Microbiol. Rev. 60, 641-696.
    • (1996) Microbiol. Rev. , vol.60 , pp. 641-696
    • Davey, H.M.1    Kell, D.B.2
  • 16
    • 79551686317 scopus 로고    scopus 로고
    • Single cell transcriptomics of hypothalamic warm sensitive neurons that control core body temperature and fever response: Signaling asymmetry and an extension of chemical neuroanatomy
    • Eberwine, J., and, Bartfai, T., (2011) Single cell transcriptomics of hypothalamic warm sensitive neurons that control core body temperature and fever response: signaling asymmetry and an extension of chemical neuroanatomy. Pharmacol. Ther. 129, 241-259.
    • (2011) Pharmacol. Ther. , vol.129 , pp. 241-259
    • Eberwine, J.1    Bartfai, T.2
  • 17
    • 0037162304 scopus 로고    scopus 로고
    • Visualization of maltose uptake in living yeast cells by fluorescent nanosensors
    • Fehr, M., Frommer, W.B., and, Lalonde, S., (2002) Visualization of maltose uptake in living yeast cells by fluorescent nanosensors. Proc. Natl Acad. Sci. USA, 99, 9846-9851.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 9846-9851
    • Fehr, M.1    Frommer, W.B.2    Lalonde, S.3
  • 18
    • 0032006222 scopus 로고    scopus 로고
    • Single neuron analysis by capillary electrophoresis with fluorescence spectroscopy
    • Fuller, R.R., Moroz, L.L., Gillette, R., and, Sweedler, J.V., (1998) Single neuron analysis by capillary electrophoresis with fluorescence spectroscopy. Neuron, 20, 173-181.
    • (1998) Neuron , vol.20 , pp. 173-181
    • Fuller, R.R.1    Moroz, L.L.2    Gillette, R.3    Sweedler, J.V.4
  • 19
    • 56949102753 scopus 로고    scopus 로고
    • Application of pressure probe and UV-MALDI-TOF MS for direct analysis of plant underivatized carbohydrates in subpicoliter single-cell cytoplasm extract
    • Gholipour, Y., Nonami, H., and, Erra-Balsells, R., (2008) Application of pressure probe and UV-MALDI-TOF MS for direct analysis of plant underivatized carbohydrates in subpicoliter single-cell cytoplasm extract. J. Am. Soc. Mass Spectrom. 19, 1841-1848.
    • (2008) J. Am. Soc. Mass Spectrom. , vol.19 , pp. 1841-1848
    • Gholipour, Y.1    Nonami, H.2    Erra-Balsells, R.3
  • 20
    • 54949110207 scopus 로고    scopus 로고
    • Heterogeneity of embryonic and adult stem cells
    • Graf, T., and, Stadtfeld, M., (2008) Heterogeneity of embryonic and adult stem cells. Cell Stem Cell, 3, 480-483.
    • (2008) Cell Stem Cell , vol.3 , pp. 480-483
    • Graf, T.1    Stadtfeld, M.2
  • 24
    • 71949111110 scopus 로고    scopus 로고
    • Matrix-free UV-laser desoption/ionization (LDI) mass spectrometric imaging at the single-cell level: Distribution of secondary metabolites of Arabidopsis thaliana and Hypericum species
    • Hölscher, D., Shroff, R., Knop, K., Gottschaldt, M., Crecelius, A., Schneider, B., Heckel, D.G., Schubert, U.S., and, Svatoš, A., (2009) Matrix-free UV-laser desoption/ionization (LDI) mass spectrometric imaging at the single-cell level: distribution of secondary metabolites of Arabidopsis thaliana and Hypericum species. Plant J. 60, 907-918.
    • (2009) Plant J. , vol.60 , pp. 907-918
    • Hölscher, D.1    Shroff, R.2    Knop, K.3    Gottschaldt, M.4    Crecelius, A.5    Schneider, B.6    Heckel, D.G.7    Schubert, U.S.8    Svatoš, A.9
  • 25
    • 77952029990 scopus 로고    scopus 로고
    • A concise review of mass spectrometry imaging
    • van Hove, E.R.A., Smith, D.F., and, Heeren, R.M.A., (2010) A concise review of mass spectrometry imaging. J. Chromatogr. A, 1217, 3946-3954.
    • (2010) J. Chromatogr. A , vol.1217 , pp. 3946-3954
    • Van Hove, E.R.A.1    Smith, D.F.2    Heeren, R.M.A.3
  • 26
    • 0028970231 scopus 로고
    • Exploring single-cell dynamics using chemically-modified microelectrodes
    • Huang, L., and, Kennedy, R.T., (1995) Exploring single-cell dynamics using chemically-modified microelectrodes. Trends Anal. Chem. 14, 158-164.
    • (1995) Trends Anal. Chem. , vol.14 , pp. 158-164
    • Huang, L.1    Kennedy, R.T.2
  • 27
    • 79953273690 scopus 로고    scopus 로고
    • Validating transcripts with probes and imaging technology
    • Itzkovitz, S., and, van Oudenaarden, A., (2011) Validating transcripts with probes and imaging technology. Nat. Methods, 8, S12-S19.
    • (2011) Nat. Methods , vol.8
    • Itzkovitz, S.1    Van Oudenaarden, A.2
  • 28
    • 77951047760 scopus 로고    scopus 로고
    • High-spatial and high-mass resolution imaging of surface metabolites of Arabidopsis thaliana by laser desorption-ionization mass spectrometry using colloidal silver
    • Jun, J.H., Song, Z., Liu, Z., Nikolau, B.J., Yeung, E.S., and, Lee, Y.J., (2010) High-spatial and high-mass resolution imaging of surface metabolites of Arabidopsis thaliana by laser desorption-ionization mass spectrometry using colloidal silver. Anal. Chem. 82, 3255-3265.
    • (2010) Anal. Chem. , vol.82 , pp. 3255-3265
    • Jun, J.H.1    Song, Z.2    Liu, Z.3    Nikolau, B.J.4    Yeung, E.S.5    Lee, Y.J.6
  • 30
    • 79955048922 scopus 로고    scopus 로고
    • MALDI-imaging mass spectrometry - An emerging technique in plant biology
    • Kaspar, S., Peukert, M., Svatos, A., Matros, A., and, Mock, H.P., (2011) MALDI-imaging mass spectrometry-An emerging technique in plant biology. Proteomics, 11, 1840-1850.
    • (2011) Proteomics , vol.11 , pp. 1840-1850
    • Kaspar, S.1    Peukert, M.2    Svatos, A.3    Matros, A.4    Mock, H.P.5
  • 32
    • 0344962433 scopus 로고    scopus 로고
    • Single cell technology
    • Kehr, J., (2003) Single cell technology. Curr. Opin. Plant Biol. 6, 617-621.
    • (2003) Curr. Opin. Plant Biol. , vol.6 , pp. 617-621
    • Kehr, J.1
  • 33
    • 0032213184 scopus 로고    scopus 로고
    • Transgenic plants changed in carbon allocation pattern display a shift in diurnal growth pattern
    • Kehr, J., Hustiak, F., Walz, C., Willmitzer, L., and, Fisahn, J., (1998) Transgenic plants changed in carbon allocation pattern display a shift in diurnal growth pattern. Plant J. 16, 497-503.
    • (1998) Plant J. , vol.16 , pp. 497-503
    • Kehr, J.1    Hustiak, F.2    Walz, C.3    Willmitzer, L.4    Fisahn, J.5
  • 35
    • 0034971009 scopus 로고    scopus 로고
    • Nuclear magnetic resonance micro-imaging in the investigation of plant cell metabolism
    • Köckenberger, W., (2001) Nuclear magnetic resonance micro-imaging in the investigation of plant cell metabolism. J. Exp. Bot. 52, 641-652.
    • (2001) J. Exp. Bot. , vol.52 , pp. 641-652
    • Köckenberger, W.1
  • 37
    • 77649253729 scopus 로고    scopus 로고
    • Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation
    • Kurczy, M.E., Piehowski, P.D., van Bell, C.T., Heien, M.L., Winograd, N., and, Ewing, A.G., (2010) Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation. Proc. Natl Acad. Sci. USA, 107, 2751-2756.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 2751-2756
    • Kurczy, M.E.1    Piehowski, P.D.2    Van Bell, C.T.3    Heien, M.L.4    Winograd, N.5    Ewing, A.G.6
  • 38
    • 67650770354 scopus 로고    scopus 로고
    • Capillary electrophoresis with electrospray ionization mass spectrometric detection for single-cell metabolomics
    • Lapainis, T., Rubakhin, S.S., and, Sweedler, J.V., (2009) Capillary electrophoresis with electrospray ionization mass spectrometric detection for single-cell metabolomics. Anal. Chem. 81, 5858-5864.
    • (2009) Anal. Chem. , vol.81 , pp. 5858-5864
    • Lapainis, T.1    Rubakhin, S.S.2    Sweedler, J.V.3
  • 40
    • 78649499977 scopus 로고    scopus 로고
    • Overview of single-cell analyses: Microdevices and applications
    • Lindström, S., and, Andersson-Svahn, H., (2010) Overview of single-cell analyses: microdevices and applications. Lab Chip, 10, 3363-3372.
    • (2010) Lab Chip , vol.10 , pp. 3363-3372
    • Lindström, S.1    Andersson-Svahn, H.2
  • 41
    • 79551595187 scopus 로고    scopus 로고
    • Miniaturization of biological assays - Overview on microwell devices for single-cell analyses
    • Lindström, S., and, Andersson-Svahn, H., (2011) Miniaturization of biological assays-Overview on microwell devices for single-cell analyses. Biochim. Biophys. Acta, 1810, 308-316.
    • (2011) Biochim. Biophys. Acta , vol.1810 , pp. 308-316
    • Lindström, S.1    Andersson-Svahn, H.2
  • 42
    • 78651496192 scopus 로고    scopus 로고
    • Real-time imaging of the HIV-1 transcription cycle in single living cells
    • Maiuri, P., Knezevich, A., Bertrand, E., and, Marcello, A., (2011) Real-time imaging of the HIV-1 transcription cycle in single living cells. Methods, 53, 62-67.
    • (2011) Methods , vol.53 , pp. 62-67
    • Maiuri, P.1    Knezevich, A.2    Bertrand, E.3    Marcello, A.4
  • 43
    • 33646575914 scopus 로고    scopus 로고
    • Microfluidic single-cell mRNA isolation and analysis
    • Marcus, J.S., Anderson, W.F., and, Quake, S.R., (2006) Microfluidic single-cell mRNA isolation and analysis. Anal. Chem. 78, 3084-3089.
    • (2006) Anal. Chem. , vol.78 , pp. 3084-3089
    • Marcus, J.S.1    Anderson, W.F.2    Quake, S.R.3
  • 44
    • 0034966230 scopus 로고    scopus 로고
    • The use of microelectrodes to investigate compartmentation and the transport of metabolized inorganic ions in plants
    • Miller, A.J., Cookson, S.J., Smith, S.J., and, Wells, D.M., (2001) The use of microelectrodes to investigate compartmentation and the transport of metabolized inorganic ions in plants. J. Exp. Bot. 52, 541-549.
    • (2001) J. Exp. Bot. , vol.52 , pp. 541-549
    • Miller, A.J.1    Cookson, S.J.2    Smith, S.J.3    Wells, D.M.4
  • 46
    • 0034688452 scopus 로고    scopus 로고
    • Analysis of pigment accumulation heterogeneity in plant cell population by image-processing system
    • Miyanaga, K., Seki, M., and, Furusaki, S., (2000) Analysis of pigment accumulation heterogeneity in plant cell population by image-processing system. Biotechnol. Bioeng. 67, 493-497.
    • (2000) Biotechnol. Bioeng. , vol.67 , pp. 493-497
    • Miyanaga, K.1    Seki, M.2    Furusaki, S.3
  • 47
    • 65249147184 scopus 로고    scopus 로고
    • Plant micrometabolomics: The analysis of endogenous metabolites present in a plant cell or tissue
    • Moco, S., Schneider, B., and, Vervoort, J., (2009) Plant micrometabolomics: the analysis of endogenous metabolites present in a plant cell or tissue. J. Proteome Res. 8, 1694-1703.
    • (2009) J. Proteome Res. , vol.8 , pp. 1694-1703
    • Moco, S.1    Schneider, B.2    Vervoort, J.3
  • 48
    • 76249121699 scopus 로고    scopus 로고
    • An ATP fluorescent chemosensor based on a Zn(II)-complexed dipicolylamine receptor coupled with a naphthalimide chromophore
    • Moro, A.J., Cywinski, P.J., Korsten, S., and, Mohr, G.J., (2010) An ATP fluorescent chemosensor based on a Zn(II)-complexed dipicolylamine receptor coupled with a naphthalimide chromophore. Chem. Commun. 46, 1085-1087.
    • (2010) Chem. Commun. , vol.46 , pp. 1085-1087
    • Moro, A.J.1    Cywinski, P.J.2    Korsten, S.3    Mohr, G.J.4
  • 49
    • 77949798724 scopus 로고    scopus 로고
    • Monitoring real-time metabolism of living cells by fast two-dimensional NMR spectroscopy
    • Motta, A., Paris, D., and, Melck, D., (2010) Monitoring real-time metabolism of living cells by fast two-dimensional NMR spectroscopy. Anal. Chem. 82, 2405-2411.
    • (2010) Anal. Chem. , vol.82 , pp. 2405-2411
    • Motta, A.1    Paris, D.2    Melck, D.3
  • 50
    • 33745952391 scopus 로고    scopus 로고
    • Laser microdissection of plant tissue: What you see is what you get
    • Nelson, T., Tausta, S.L., Gandotra, N., and, Liu, T., (2006) Laser microdissection of plant tissue: what you see is what you get. Annu. Rev. Plant Biol. 57, 181-201.
    • (2006) Annu. Rev. Plant Biol. , vol.57 , pp. 181-201
    • Nelson, T.1    Tausta, S.L.2    Gandotra, N.3    Liu, T.4
  • 51
    • 35848963639 scopus 로고    scopus 로고
    • Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry
    • Nemes, P., and, Vertes, A., (2007) Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry. Anal. Chem. 79, 8098-8106.
    • (2007) Anal. Chem. , vol.79 , pp. 8098-8106
    • Nemes, P.1    Vertes, A.2
  • 53
    • 0030329380 scopus 로고    scopus 로고
    • Single-cell analysis of gene expression in the nervous system. Measurements at the edge of chaos
    • O'Dowd, D.K., and, Smith, M.A., (1996) Single-cell analysis of gene expression in the nervous system. Measurements at the edge of chaos. Mol. Neurobiol. 13, 199-211.
    • (1996) Mol. Neurobiol. , vol.13 , pp. 199-211
    • O'Dowd, D.K.1    Smith, M.A.2
  • 54
    • 80053584823 scopus 로고    scopus 로고
    • Metabolomics of a single vacule reveals metabolic dynamism in an Alga Chara austarlis
    • Oikawa, A., Matsuda, F., Kikuyama, M., Mimura, T., and, Saito, K., (2011) Metabolomics of a single vacule reveals metabolic dynamism in an Alga Chara austarlis. Plant Physiol. 157, 544-551.
    • (2011) Plant Physiol. , vol.157 , pp. 544-551
    • Oikawa, A.1    Matsuda, F.2    Kikuyama, M.3    Mimura, T.4    Saito, K.5
  • 55
    • 20844449080 scopus 로고    scopus 로고
    • Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors
    • Okumoto, S., Looger, L.L., Micheva, K.D., Reimer, R.J., Smith, S.J., and, Frommer, W.B., (2005) Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. Proc. Natl Acad. Sci. USA, 102, 8740-8745.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 8740-8745
    • Okumoto, S.1    Looger, L.L.2    Micheva, K.D.3    Reimer, R.J.4    Smith, S.J.5    Frommer, W.B.6
  • 56
    • 0032042368 scopus 로고    scopus 로고
    • The nanoliter niche. NMR detection for trace analysis and capillary separations
    • Olson, D.L., Lacey, M.E., and, Sweedler, J.V., (1998) The nanoliter niche. NMR detection for trace analysis and capillary separations. Anal. Chem. 70, 257A-264A.
    • (1998) Anal. Chem. , vol.70
    • Olson, D.L.1    Lacey, M.E.2    Sweedler, J.V.3
  • 58
    • 43749110297 scopus 로고    scopus 로고
    • Investigating glutamate receptor-like gene co-expression in Arabidopsis thaliana
    • Roy, S.J., Gilliham, M., Berger, B., et al. (2008) Investigating glutamate receptor-like gene co-expression in Arabidopsis thaliana. Plant Cell Environ. 31, 861-871.
    • (2008) Plant Cell Environ. , vol.31 , pp. 861-871
    • Roy, S.J.1    Gilliham, M.2    Berger, B.3
  • 59
    • 79953272976 scopus 로고    scopus 로고
    • A mass spectrometry primer for mass spectrometry imaging
    • Rubakhin, S.S., and, Sweedler, J.V., (2010) A mass spectrometry primer for mass spectrometry imaging. Methods Mol. Biol. 656, 21-49.
    • (2010) Methods Mol. Biol. , vol.656 , pp. 21-49
    • Rubakhin, S.S.1    Sweedler, J.V.2
  • 61
    • 0026752599 scopus 로고
    • The application of 3D chemical shift microscopy to non-invasive histochemistry
    • Rumpel, H., and, Pope, J.M., (1992) The application of 3D chemical shift microscopy to non-invasive histochemistry. Magn. Reson. Imaging, 10, 187-194.
    • (1992) Magn. Reson. Imaging , vol.10 , pp. 187-194
    • Rumpel, H.1    Pope, J.M.2
  • 62
    • 77951880802 scopus 로고    scopus 로고
    • Metabolomics for functional genomics, systems biology, and biotechnology
    • Saito, K., and, Matsuda, F., (2010) Metabolomics for functional genomics, systems biology, and biotechnology. Annu. Rev. Plant Biol. 61, 463-489.
    • (2010) Annu. Rev. Plant Biol. , vol.61 , pp. 463-489
    • Saito, K.1    Matsuda, F.2
  • 63
    • 33745944637 scopus 로고    scopus 로고
    • Metabolic profiling of laser microdissected vascular bundles of Arabidopsis thaliana
    • Schad, M., Mungur, R., Fiehn, O., and, Kehr, J., (2005) Metabolic profiling of laser microdissected vascular bundles of Arabidopsis thaliana. Plant Methods, 1, 2.
    • (2005) Plant Methods , vol.1 , pp. 2
    • Schad, M.1    Mungur, R.2    Fiehn, O.3    Kehr, J.4
  • 64
    • 79953280811 scopus 로고    scopus 로고
    • Long-term single-cell imaging of mammalian stem cells
    • Schroeder, T., (2011) Long-term single-cell imaging of mammalian stem cells. Nat. Methods, 8, S30-S35.
    • (2011) Nat. Methods , vol.8
    • Schroeder, T.1
  • 65
    • 0015502267 scopus 로고
    • A fluorescent modification of adenosine triphosphate with activity in enzyme systems: 1,N 6 -ethenoadenosine triphosphate
    • Secrist, J.A. 3rd, Barrio, J.R., and, Leonard, N.J., (1972) A fluorescent modification of adenosine triphosphate with activity in enzyme systems: 1,N 6 -ethenoadenosine triphosphate. Science, 175, 646-647.
    • (1972) Science , vol.175 , pp. 646-647
    • Secrist II, J.A.1    Barrio, J.R.2    Leonard, N.J.3
  • 66
    • 77954613244 scopus 로고    scopus 로고
    • Developments and applications of mass spectroscopy
    • Setou, M., Shrivas, K., Sroyraya, M., Yang, H., et al. (2010) Developments and applications of mass spectroscopy. Med. Mol. Morphol. 43, 1-5.
    • (2010) Med. Mol. Morphol. , vol.43 , pp. 1-5
    • Setou, M.1    Shrivas, K.2    Sroyraya, M.3    Yang, H.4
  • 67
    • 70449857638 scopus 로고    scopus 로고
    • In situ metabolic profiling of single cells by laser ablation electrospray ionization mass spectrometry
    • Shrestha, B., and, Vertes, A., (2009) In situ metabolic profiling of single cells by laser ablation electrospray ionization mass spectrometry. Anal. Chem. 81, 8265-8271.
    • (2009) Anal. Chem. , vol.81 , pp. 8265-8271
    • Shrestha, B.1    Vertes, A.2
  • 68
    • 79954541196 scopus 로고    scopus 로고
    • In situ cell-by-cell imaging and analysis of small cell populations by mass spectrometry
    • Shrestha, B., Patt, J.M., and, Vertes, A., (2011) In situ cell-by-cell imaging and analysis of small cell populations by mass spectrometry. Anal. Chem. 83, 2947-2955.
    • (2011) Anal. Chem. , vol.83 , pp. 2947-2955
    • Shrestha, B.1    Patt, J.M.2    Vertes, A.3
  • 69
    • 79953278332 scopus 로고    scopus 로고
    • Supplement on single-cell analysis
    • de Souza, N., (2011) Supplement on single-cell analysis. Nat. Methods, 8, S1.
    • (2011) Nat. Methods , vol.8
    • De Souza, N.1
  • 70
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and, Yamanaka, S., (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131, 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 71
    • 67349146589 scopus 로고    scopus 로고
    • MRNA-Seq whole-transcriptome analysis of a single cell
    • Tang, F., Barbacioru, C., Wang, Y., et al. (2009) mRNA-Seq whole-transcriptome analysis of a single cell. Nat. Methods, 6, 377-382.
    • (2009) Nat. Methods , vol.6 , pp. 377-382
    • Tang, F.1    Barbacioru, C.2    Wang, Y.3
  • 72
    • 79953288433 scopus 로고    scopus 로고
    • Development and applications of single-cell transcriptome analysis
    • Tang, F., Lao, K., and, Surani, M.A., (2011) Development and applications of single-cell transcriptome analysis. Nat. Methods, 8, S6-S11.
    • (2011) Nat. Methods , vol.8
    • Tang, F.1    Lao, K.2    Surani, M.A.3
  • 73
    • 67649586670 scopus 로고    scopus 로고
    • Quantitative analysis of gene expression in a single cell by qPCR
    • Taniguchi, K., Kajiyama, T., and, Kambara, H., (2009) Quantitative analysis of gene expression in a single cell by qPCR. Nat. Methods, 6, 503-506.
    • (2009) Nat. Methods , vol.6 , pp. 503-506
    • Taniguchi, K.1    Kajiyama, T.2    Kambara, H.3
  • 74
    • 71749100787 scopus 로고    scopus 로고
    • Direct single-cell molecular analysis of plant tissues by video mass specrometry
    • Tejedor, M.L., Mizuno, H., Tsuyama, N., Harada, T., and, Masujima, T., (2009) Direct single-cell molecular analysis of plant tissues by video mass specrometry. Anal. Sci. 25, 1053-1055.
    • (2009) Anal. Sci. , vol.25 , pp. 1053-1055
    • Tejedor, M.L.1    Mizuno, H.2    Tsuyama, N.3    Harada, T.4    Masujima, T.5
  • 75
    • 0033505415 scopus 로고    scopus 로고
    • The pressure probe: A versatile tool in plant cell physiology
    • Tomos, A.D., and, Leigh, R.A., (1999) The pressure probe: a versatile tool in plant cell physiology. Annu. Rev. Plant Physiol. Plant Mol. Biol. 50, 447-472.
    • (1999) Annu. Rev. Plant Physiol. Plant Mol. Biol. , vol.50 , pp. 447-472
    • Tomos, A.D.1    Leigh, R.A.2
  • 76
    • 0034966593 scopus 로고    scopus 로고
    • Cell sampling and analysis (SiCSA): Metabolites measured at single cell resolution
    • Tomos, A.D., and, Sharrock, R.A., (2001) Cell sampling and analysis (SiCSA): metabolites measured at single cell resolution. J. Exp. Bot. 52, 623-630.
    • (2001) J. Exp. Bot. , vol.52 , pp. 623-630
    • Tomos, A.D.1    Sharrock, R.A.2
  • 77
    • 79951501147 scopus 로고    scopus 로고
    • Mass spectrometry for cellular and tissue analyses in a very small region
    • Tsuyama, N., Mizuno, H., and, Masujima, T., (2011) Mass spectrometry for cellular and tissue analyses in a very small region. Anal. Sci. 27, 163-170.
    • (2011) Anal. Sci. , vol.27 , pp. 163-170
    • Tsuyama, N.1    Mizuno, H.2    Masujima, T.3
  • 78
    • 79551553749 scopus 로고    scopus 로고
    • Studying transcriptional interactions in single cells at sufficient resolution
    • Wallden, M., and, Elf, J., (2011) Studying transcriptional interactions in single cells at sufficient resolution. Curr. Opin. Biotechnol. 22, 81-86.
    • (2011) Curr. Opin. Biotechnol. , vol.22 , pp. 81-86
    • Wallden, M.1    Elf, J.2
  • 79
    • 77953121190 scopus 로고    scopus 로고
    • Single cell analysis: The new frontier in 'omics'
    • Wang, D., and, Bodovitz, S., (2010) Single cell analysis: the new frontier in 'omics'. Trends Biotechnol. 28, 281-290.
    • (2010) Trends Biotechnol. , vol.28 , pp. 281-290
    • Wang, D.1    Bodovitz, S.2
  • 80
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang, Z., Gerstein, M., and, Snyder, M., (2009) RNA-Seq: a revolutionary tool for transcriptomics. Nat. Rev. Genet. 10, 57-63.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 81
    • 33747117373 scopus 로고    scopus 로고
    • The origins and the future of microfluidics
    • Whitesides, G.M., (2006) The origins and the future of microfluidics. Nature, 442, 368-373.
    • (2006) Nature , vol.442 , pp. 368-373
    • Whitesides, G.M.1
  • 83
    • 1242308248 scopus 로고    scopus 로고
    • CAMP detection methods in HTS: Selecting the best from the rest
    • Williams, C., (2004) cAMP detection methods in HTS: selecting the best from the rest. Nat. Rev. Drug Discov. 3, 125-135.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 125-135
    • Williams, C.1
  • 84
    • 11344286548 scopus 로고    scopus 로고
    • Single-cell analysis by electrochemical detection with a microfluidic device
    • Xia, F., Jin, W., Yin, X., and, Fang, Z., (2005) Single-cell analysis by electrochemical detection with a microfluidic device. J. Chromatogr. A, 1063, 227-233.
    • (2005) J. Chromatogr. A , vol.1063 , pp. 227-233
    • Xia, F.1    Jin, W.2    Yin, X.3    Fang, Z.4
  • 85
    • 0036788487 scopus 로고    scopus 로고
    • Electroanalysis of metabolic flux from single cells in simple picoliter-volume microsystems
    • Yasukawa, T., Glidle, A., Cooper, J.M., and, Matsue, T., (2002) Electroanalysis of metabolic flux from single cells in simple picoliter-volume microsystems. Anal. Chem. 74, 5001-5008.
    • (2002) Anal. Chem. , vol.74 , pp. 5001-5008
    • Yasukawa, T.1    Glidle, A.2    Cooper, J.M.3    Matsue, T.4


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