Chemical synthesis of homogeneous human glycosyl-interferon-β that exhibits potent antitumor activity in vivo

Journal of the American Chemical Society

Volumn 134, Issue 12, 2012, Pages 5428-5431

  Sakamoto, Izumi ^a   Tezuka, Katsunari ^a,b   Fukae, Kazuhiro ^a   Ishii, Kazuyuki ^a   Taduru, Keisuke ^a   Maeda, Masatoshi ^a   Ouchi, Masaki ^a   Yoshida, Kenta ^a   Nambu, Yuri ^a   Igarashi, Jun ^a   Hayashi, Naohiro ^a   Tsuji, Takashi ^b   Kajihara, Yasuhiro ^c  

^a OTSUKA CHEMICAL CO LTD   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR ACTIVITIES; CHEMICAL SYNTHESIS; DEPROTECTION; DISULFIDE BONDS; GLYCOSYLATED; IN-VIVO; NATIVE CHEMICAL LIGATION; POLYPEPTIDE CHAIN; SYNTHETIC PEPTIDE;

ANTIBIOTICS; BIOTECHNOLOGY; COVALENT BONDS; DESULFURIZATION; PEPTIDES;

GLYCOPROTEINS;

AMINO ACID; BETA INTERFERON; GLYCAN; GLYCOPROTEIN; GLYCOSYL BETA INTERFERON; OLIGOSACCHARIDE; POLYPEPTIDE; RECOMBINANT BETA INTERFERON; SIALIC ACID; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHO CELL; CONTROLLED STUDY; DAUDI CELL; DESULFURIZATION; DISULFIDE BOND; DRUG DOSAGE FORM COMPARISON; ELECTROSPRAY MASS SPECTROMETRY; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LYMPHOMA CELL; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; SCID MOUSE; SINGLE DRUG DOSE; SURFACE PLASMON RESONANCE; SYNTHESIS; TUMOR XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL PROLIFERATION; GLYCOSYLATION; HUMANS; INTERFERON-BETA; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84859143910     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2109079     Document Type: Article

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