The airway epithelium in childhood asthma

Journal of Allergy and Clinical Immunology

Volumn 129, Issue 4, 2012, Pages 998-999

  O'Byrne, Paul M ^a   Pedersen, Søren ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Bronchial epithelium; nasal epithelium; remodeling

Indexed keywords

ALLERGEN; CORTICOSTEROID; INTERLEUKIN 13; INTERLEUKIN 4; IRRITANT AGENT; SCLEROPROTEIN; TOXIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2;

AIRWAY OBSTRUCTION; AIRWAY REMODELING; ASTHMA; BRONCHUS MUCOSA; CELL STRUCTURE; CHILDHOOD ASTHMA; CHILDHOOD DISEASE; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; EDITORIAL; EPITHELIUM CELL; FIBEROPTIC BRONCHOSCOPY; FIBROBLAST; FOLLOW UP; GOBLET CELL; HUMAN; IN VIVO STUDY; LUNG FUNCTION; MAST CELL; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

ASTHMA; CHILD; CHILD, PRESCHOOL; HUMANS; RESPIRATORY MUCOSA;

EID: 84859141602     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.02.030     Document Type: Editorial

References (15)

1. D.W. Empey, L.A. Laitinen, L. Jacobs, W.M. Gold, and J.A. Nadel Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection Am Rev Respir Dis 113 1976 131 139
2. J.C. Hogg Bronchial mucosal permeability and its relationship to airways hyperreactivity Eur J Respir Dis Suppl 122 1982 17 22
3. L.A. Laitinen, M. Heino, A. Laitinen, T. Kava, and T. Haahtela Damage of the airway epithelium and bronchial reactivity in patients with asthma Am Rev Respir Dis 131 1985 599 606
4. P.K. Jeffery, A.J. Wardlaw, F.C. Nelson, J.V. Collins, and A.B. Kay Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity Am Rev Respir Dis 140 1989 1745 1753
5. S.T. Holgate, J. Holloway, S. Wilson, F. Bucchieri, S. Puddicombe, and D.E. Davies Epithelial-mesenchymal communication in the pathogenesis of chronic asthma Proc Am Thorac Soc 1 2004 93 98
6. D.N. Payne, A.V. Rogers, E. Adelroth, V. Bandi, K.K. Guntupalli, and A. Bush Early thickening of the reticular basement membrane in children with difficult asthma Am J Respir Crit Care Med 167 2003 78 82
7. J. Chakir, M. Laviolette, M. Boutet, R. Laliberte, J. Dube, and L.P. Boulet Lower airways remodeling in nonasthmatic subjects with allergic rhinitis Lab Invest 75 1996 735 744
8. M.R. Sears, J.M. Greene, A.R. Willan, E.M. Wiecek, D.R. Taylor, and E.M. Flannery A longitudinal, population-based, cohort study of childhood asthma followed to adulthood N Engl J Med 349 2003 1414 1422
9. J.M. Lopez-Guisa, C. Powers, D. File, E. Cochrane, N. Jimenez, and J.S. Debley Airway epithelial cells from asthmatic children differentially express proremodeling factors J Allergy Clin Immunol 129 2012 990 997
10. S.C. Foley, A.K. Mogas, R. Olivenstein, P.O. Fiset, J. Chakir, and J. Bourbeau Increased expression of ADAM33 and ADAM8 with disease progression in asthma J Allergy Clin Immunol 119 2007 863 871
11. L.A. Laitinen, A. Laitinen, and T. Haahtela A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial J Allergy Clin Immunol 90 1992 32 42
12. L. Agertoft, and S. Pedersen Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children Respir Med 88 1994 373 381
13. R.A. Pauwels, S. Pedersen, W.W. Busse, W.C. Tan, Y.Z. Chen, and S.V. Ohlsson Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial Lancet 361 2003 1071 1076
14. P.M. O'Byrne, S. Pedersen, W.W. Busse, W.C. Tan, Y.Z. Chen, and S.V. Ohlsson Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma Chest 129 2006 1478 1485
15. J.K. Sont, L.N. Willems, E.H. Bel, J.H. van Krieken, J.P. Vandenbroucke, and P.J. Sterk Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group Am J Respir Crit Care Med 159 1999 1043 1051