Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability

Chemico-Biological Interactions

Volumn 197, Issue 1, 2012, Pages 16-22

  Kapetanovic, Izet M ^a   Lyubimov, Alexander V ^b   Kabirova, Elena V ^b   Kabirov, Kasim K ^b   Rasay, Laura ^c   Swezey, Robert ^c   Green, Carol ^c   Kopelovich, Levy ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c SRI INTERNATIONAL   (United States)

Author keywords

Ames assay; Chemoprevention; Dog; Nitro compounds; Nitroreductases; Rat

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; DRUG METABOLITE; NITROREDUCTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BACTERIAL METABOLISM; BACTERIAL MUTATION; BACTERIAL STRAIN; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG TISSUE LEVEL; ENZYME METABOLISM; FEMALE; IN VIVO STUDY; INTESTINE FLORA; MALE; METABOLIC ACTIVATION; MUTAGENICITY; NONHUMAN; RAT; SPECIES DIFFERENCE; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMINES; ANILIDES; ANIMALS; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; DOGS; MALE; MUTAGENS; NITROREDUCTASES; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; SALMONELLA TYPHIMURIUM;

ANIMALIA; BACTERIA (MICROORGANISMS); CANIS FAMILIARIS; RATTUS;

EID: 84859140289     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.03.002     Document Type: Article

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