A randomized trial of methotrexate vs. azathioprine for severe atopic eczema: A critical appraisal

British Journal of Dermatology

Volumn 166, Issue 4, 2012, Pages 701-703

  Patel, A N ^a   Langan, S M ^b   Batchelor, J M ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; METHOTREXATE; PREDNISOLONE;

ADULT; ARTICLE; ATOPIC DERMATITIS; BLOOD CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; ECZEMA AREA AND SEVERITY INDEX; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HUMAN; INSOMNIA; INVESTIGATOR GLOBAL ASSESSMENT; MALE; NETHERLANDS; OUTCOME ASSESSMENT; PATIENT GLOBAL ASSESSMENT; PATIENT ORIENTED ECZEMA MEASUREMENT; PRIORITY JOURNAL; PRURITUS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SCORING OF ATOPIC DERMATITIS INDEX; SIDE EFFECT; SKINDEX 17; THYMUS; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; VISUAL ANALOG SCALE;

EID: 84859139636     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2012.10872.x     Document Type: Article

References (20)

1. Schram ME, Roekevisch E, Leeflang MMG, et al. A randomized trial of methotrexate versus azathioprine for severe atopic eczema. J Allergy Clin Immunol 2011; 128: 353-9.
2. Chakravarty K, McDonald H, Pullar T, et al. BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists. Rheumatology (Oxford) 2008; 47: 924-5.
3. Weatherhead SC, Wahie S, Reynolds NJ, Meggitt SJ,. An open-label, dose-ranging study of methotrexate for moderate-to-severe adult atopic eczema. Br J Dermatol 2007; 156: 346-51.
4. Zoller L, Ramon M, Bergman R,. Low dose methotrexate therapy is effective in late-onset atopic dermatitis and idiopathic eczema. Isr Med Assoc J 2008; 10: 413-14.
5. Goujon C, Berard F, Dahel K, et al. Methotrexate for the treatment of adult atopic dermatitis. Eur J Dermatol 2006; 16: 155-8.
6. Shaffrali FC, Colver GB, Messenger AG, Gawkrodger DJ,. Experience with low dose methotrexate for the treatment of eczema in the elderly. J Am Acad Dermatol 2003; 48: 417-19.
7. Berth-Jones J, Takwale A, Tan E, et al. Azathioprine in severe adult atopic dermatitis: a double-blind, placebo-controlled, crossover trial. Br J Dermatol 2002; 147: 324-30.
8. Meggitt SJ, Gray JC, Reynolds NJ,. Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial. Lancet 2006; 367: 839-46.
9. Schulz KF, Altman DG, Moher D, for the CONSORT Group. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMJ 2010; 340: c332.
10. Rajka G, Langeland T,. Grading of the severity of atopic dermatitis. Acta Derm Venereol (Stockh) 1989; 144: 13-14.
11. Rothwell PM,. External validity of randomised controlled trials: 'to whom do the results of this trial apply?' Lancet 2005; 365: 82-93.
12. CONSORT. Selection Bias. Available at: http://www.consort-statement.org/ resources/glossary/q--z/selection-bias/ (last accessed 15 January 2012).
13. CONSORT. Ascertainment Bias. Available at: http://www.consortstatement. org/resources/glossary/a--d/ascertainment-bias/ (last accessed 15 January 2012).
14. Hamilton L,. Data Analysis for Social Scientists: A First Course in Applied Statistics. Belmont, CA: Duxbury Press, 1996.
15. Cohen J,. Statistical Power Analysis for the Behavioral Sciences, 2nd edn. Hillsdale, NJ: Lawrence Erlbaum Associates Inc., 1988.
16. Bland M,. An Introduction to Medical Statistics, 3rd edn. Oxford: Oxford University Press, 2000.
17. Munro BH,. Statistical Methods for Health Care Research, 5th edn. Philadelphia, PA: Lippincott Williams & Wilkins, 2005.
18. Siegel S, Castellan NJ,. Nonparametric Statistics for the Behavioral Sciences. New York, NY: McGraw-Hill Book Company, 1988.
19. Paul C, Lahfa M, Bachelez H, et al. A randomized controlled evaluator-blinded trial of intravenous immunoglobulin in adults with severe atopic dermatitis. Br J Dermatol 2002; 147: 518-22.
20. Schmitt J, Meurer M, Schwanebeck U, et al. Treatment following an evidence-based algorithm versus individualised symptom-oriented treatment for atopic eczema. A randomised controlled trial. Dermatology 2008; 217: 299-308.