TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Kolbus, Daniel ^a   Ljungcrantz, Irena ^a   Söderberg, Ingrid ^a   Alm, Ragnar ^a   Björkbacka, Harry ^a   Nilsson, Jan ^a   Fredrikson, Gunilla Nordin ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b MALMÖ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; AORTA ROOT; ARTICLE; ATHEROGENESIS; CD3+ T LYMPHOCYTE; CD4 LYMPHOCYTE PERCENTAGE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS PRESENTATION; EFFECTOR CELL; FEMALE; HYPERCHOLESTEROLEMIA; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PROTEIN DEFICIENCY; T LYMPHOCYTE SUBPOPULATION; TISSUE SECTION;

ANIMALS; ANTIGEN-PRESENTING CELLS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; CYTOKINES; FEMALE; IMMUNOPHENOTYPING; LIPID METABOLISM; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLAQUE, ATHEROSCLEROTIC; T-LYMPHOCYTES;

MUS;

EID: 84859127470     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033932     Document Type: Article

References (25)

1. Ross R, (1999) Atherosclerosis is an inflammatory disease. Am Heart J 138: S419-420.
2. Nilsson J, Hansson GK, (2008) Autoimmunity in atherosclerosis: a protective response losing control? J Intern Med 263: 464-478.
3. Frostegard J, Wu R, Giscombe R, Holm G, Lefvert AK, et al. (1992) Induction of T-cell activation by oxidized low density lipoprotein. Arterioscler Thromb 12: 461-467.
4. Stemme S, Faber B, Holm J, Wiklund O, Witztum JL, et al. (1995) T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc Natl Acad Sci U S A 92: 3893-3897.
5. Zhou X, Nicoletti A, Elhage R, Hansson GK, (2000) Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice. Circulation 102: 2919-2922.
6. Zhou X, Robertson AK, Rudling M, Parini P, Hansson GK, (2005) Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis. Circ Res 96: 427-434.
7. Elhage R, Gourdy P, Brouchet L, Jawien J, Fouque MJ, et al. (2004) Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. Am J Pathol 165: 2013-2018.
8. Dansky HM, Charlton SA, Harper MM, Smith JD, (1997) T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A 94: 4642-4646.
9. Mallat Z, Gojova A, Brun V, Esposito B, Fournier N, et al. (2003) Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice. Circulation 108: 1232-1237.
10. Ait-Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, et al. (2006) Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12: 178-180.
11. Gewaltig J, Kummer M, Koella C, Cathomas G, Biedermann BC, (2008) Requirements for CD8 T-cell migration into the human arterial wall. Hum Pathol 39: 1756-1762.
12. Ludewig B, Freigang S, Jaggi M, Kurrer MO, Pei YC, et al. (2000) Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model. Proc Natl Acad Sci U S A 97: 12752-12757.
13. Kolbus D, Ramos OH, Berg KE, Persson J, Wigren M, et al. (2010) CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe(/) mice. BMC Immunol 11: 58.
14. Van Kaer L, Ashton-Rickardt PG, Ploegh HL, Tonegawa S, (1992) TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell 71: 1205-1214.
15. Ljunggren HG, Glas R, Sandberg JK, Karre K, (1996) Reactivity and specificity of CD8+ T cells in mice with defects in the MHC class I antigen-presenting pathway. Immunol Rev 151: 123-148.
16. Rock KL, Shen L, (2005) Cross-presentation: underlying mechanisms and role in immune surveillance. Immunol Rev 207: 166-183.
17. Jones M, Cordell JL, Beyers AD, Tse AG, Mason DY, (1993) Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies. J Immunol 150: 5429-5435.
18. Brånén L, Pettersson L, Lindholm M, Zaina S, (2001) A procedure for obtaining whole mount mouse aortas that allows atherosclerotic lesions to be quantified. Histochem J 33: 227-229.
19. Suzuki H, Shi Z, Okuno Y, Isobe K, (2008) Are CD8+CD122+ cells regulatory T cells or memory T cells? Hum Immunol 69: 751-754.
20. de la Salle H, Hanau D, Fricker D, Urlacher A, Kelly A, et al. (1994) Homozygous human TAP peptide transporter mutation in HLA class I deficiency. Science 265: 237-241.
21. Aldrich CJ, Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, et al. (1994) Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proc Natl Acad Sci U S A 91: 6525-6528.
22. Xiang J, Huang H, Liu Y, (2005) A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells. J Immunol 174: 7497-7505.
23. Sandberg JK, Chambers BJ, Van Kaer L, Karre K, Ljunggren HG, (1996) TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity. Eur J Immunol 26: 288-293.
24. Medina F, Ramos M, Iborra S, de Leon P, Rodriguez-Castro M, et al. (2009) Furin-processed antigens targeted to the secretory route elicit functional TAP1-/-CD8+ T lymphocytes in vivo. J Immunol 183: 4639-4647.
25. Epstein SE, Zhou YF, Zhu J, (1999) Potential role of cytomegalovirus in the pathogenesis of restenosis and atherosclerosis. Am Heart J 138: S476-478.