T cell epitopes of the timothy grass pollen allergen Phl p 5 of mice and men and the detection of allergen-specific T cells using class II ultimers

International Archives of Allergy and Immunology

Volumn 158, Issue 4, 2012, Pages 326-334

  Stoecklinger, Angelika ^a   Scheiblhofer, Sandra ^a   Roesler, Elisabeth ^a   Lang, Andreas ^a   Fastner, Gerd ^b   Sedlmayer, Felix ^b   Lang, Roland ^c   Danzer, Martin ^d   Thalhamer, Josef ^a   Weiss, Richard ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b University Clinic of Radiotherapy and Radiation Oncology and RadART   (Austria)

^c PARACELSUS MEDICAL UNIVERSITY   (Austria)

^d Red Cross Transfusion Service of Upper Austria   (Austria)

Author keywords

BALB c mouse; C57BL 6 mouse; Epitope mapping; Phl p 5; Tetramers

Indexed keywords

EPITOPE; IMMUNOGLOBULIN E; PHL P 5 ALLERGEN; POLLEN ANTIGEN; TETRAMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPY; CELL EXPANSION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; EPITOPE MAPPING; FEMALE; GRASS POLLEN; HUMAN; IMMUNE RESPONSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHLEUM PRATENSE; POLLEN ALLERGY; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; IMMUNODOMINANT EPITOPES; IMMUNOGLOBULIN E; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; STAINING AND LABELING; T-LYMPHOCYTES;

EID: 84859116579     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000333551     Document Type: Article

References (39)

1. Peden D, Reed CE: Environmental and occupational allergies. J Allergy Clin Immunol 2010; 125:S150-S160.
2. Kay AB: Allergy and allergic diseases: second of two parts. N Engl J Med 2001; 344: 109-113. (Pubitemid 32052501)
3. Kay AB: Allergy and allergic diseases: first of two parts. N Engl J Med 2001; 344: 30-37. (Pubitemid 32064843)
4. Gavett SH, Chen X, Finkelman F, Wills-Karp M: Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol 1994; 10: 587-593.
5. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB: Predominant T H2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326: 298-304.
6. Robinson DS, Ying S, Bentley AM, Meng Q, North J, Durham SR, Kay AB, Hamid Q: Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J Allergy Clin Immunol 1993; 92: 397-403. (Pubitemid 24088691)
7. Larche M, Akdis CA, Valenta R: Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006; 6: 761-771. (Pubitemid 44453462)
8. Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, Carr VA, Robinson DS: Relation of CD4+CD25+ regulatory Tcell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004; 363: 608-615. (Pubitemid 38264178)
9. Shi HZ, Qin XJ: CD4+CD25+ regulatory T lymphocytes in allergy and asthma. Allergy 2005; 60: 986-995.
10. Francis JN, Till SJ, Durham SR: Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy. J Allergy Clin Immunol 2003; 111: 1255-1261. (Pubitemid 36683679)
11. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, Thunberg S, Deniz G, Valenta R, Fiebig H, Kegel C, Disch R, Schmidt-Weber CB, Blaser K, Akdis CA: Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004; 199: 1567-1575. (Pubitemid 38780411)
12. Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, Blaser K, Akdis CA: IL-10 and TGF-cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003; 33: 1205-1214. (Pubitemid 36609138)
13. Macaubas C, Wahlstrom J, Galvao da Silva AP, Forsthuber TG, Sonderstrup G, Kwok WW, DeKruyff RH, Umetsu DT: Allergenspecific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals. J Immunol 2006; 176: 5069-5077.
14. Van Overtvelt L, Wambre E, Maillere B, von Hofe E, Louise A, Balazuc AM, Bohle B, Ebo D, Leboulaire C, Garcia G, Moingeon P: Assessment of Bet v 1-specific CD4+ T cell responses in allergic and nonallergic individuals using MHC class II peptide tetramers. J Immunol 2008; 180: 4514-4522.
15. Bullens DM, De Swerdt A, Dilissen E, Kasran A, Kroczek RA, Cadot P, Casaer P, Ceuppens JL: House dust mite-specific T cells in healthy non-atopic children. Clin Exp Allergy 2005; 35: 1535-1541.
16. Ebner C, Schenk S, Najafian N, Siemann U, Steiner R, Fischer GW, Hoffmann K, Szepfalusi Z, Scheiner O, Kraft D: Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients. J Immunol 1995; 154: 1932-1940.
17. Ebner C, Siemann U, Bohle B, Willheim M, Wiedermann U, Schenk S, Klotz F, Ebner H, Kraft D, Scheiner O: Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T cell clones specific for Phl p 1, a major grass pollen allergen. Clin Exp Allergy 1997; 27: 1007-1015.
18. Till S: Immunotherapy: readdressing the balance between TH2 and TH1 cells. Clin Exp Allergy 1997; 27: 981-985. (Pubitemid 27421825)
19. Jutel M, Pichler WJ, Skrbic D, Urwyler A, Dahinden C, Müller UR: Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. J Immunol 1995; 154: 4187-4194.
20. Texier C, Pouvelle-Moratille S, Buhot C, Castelli FA, Pecquet C, Menez A, Leynadier F, Maillere B: Emerging principles for the design of promiscuous HLA-DR-restricted peptides: an example from the major bee venom allergen. Eur J Immunol 2002; 32: 3699-3707. (Pubitemid 36024406)
21. de Lalla C, Sturniolo T, Abbruzzese L, Hammer J, Sidoli A, Sinigaglia F, Panina-Bordignon P: Cutting edge: identification of novel T cell epitopes in Lol p5a by computational prediction. J Immunol 1999; 163: 1725-1729. (Pubitemid 29382165)
22. Friedl-Hajek R, Spangfort MD, Schou C, Breiteneder H, Yssel H, Joost van Neerven RJ: Identification of a highly promiscuous and an HLA allele-specific T cell epitope in the birch major allergen Bet v 1: HLA restriction, epitope mapping and TCR sequence comparisons. Clin Exp Allergy 1999; 29: 478-487. (Pubitemid 29179817)
23. Ali FR, Larche M: Peptide-based immunotherapy: a novel strategy for allergic disease. Expert Rev Vaccines 2005; 4: 881-889. (Pubitemid 43040908)
24. Campbell JD, Buckland KF, McMillan SJ, Kearley J, Oldfield WL, Stern LJ, Gronlund H, van Hage M, Reynolds CJ, Boyton RJ, Cobbold SP, Kay AB, Altmann DM, Lloyd CM, Larche M: Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med 2009; 206: 1535-1547.
25. Campana R, Vrtala S, Maderegger B, Jertschin P, Stegfellner G, Swoboda I, Focke-Tejkl M, Blatt K, Gieras A, Zafred D, Neubauer A, Valent P, Keller W, Spitzauer S, Valenta R: Hypoallergenic derivatives of the major birch pollen allergen bet v 1 obtained by rational sequence reassembly. J Allergy Clin Immunol 2010; 126: 1024-1031.
26. Saarne T, Kaiser L, Gronlund H, Rasool O, Gafvelin G, van Hage-Hamsten M: Rational design of hypoallergens applied to the major cat allergen Fel d 1. Clin Exp Allergy 2005; 35: 657-663. (Pubitemid 40769292)
27. Bateman EA, Ardern-Jones MR, Ogg GS: Persistent central memory phenotype of circulating Fel d 1 peptide/DRB1 * 0101 tetramer-binding CD4+ T cells. J Allergy Clin Immunol 2006; 118: 1350-1356. (Pubitemid 44854112)
28. Kinnunen T, Jutila K, Kwok WW, Rytkonen-Nissinen M, Immonen A, Saarelainen S, Narvanen A, Taivainen A, Virtanen T: Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy. J Allergy Clin Immunol 2007; 119: 965-972. (Pubitemid 46527828)
29. Kwok WW, Roti M, Delong JH, Tan V, Wambre E, James EA, Robinson D: Direct ex vivo analysis of allergen-specific CD4+ T cells. J Allergy Clin Immunol 2010; 125: 1407-1409.
30. Andersson K, Lidholm J: Characteristics and immunobiology of grass pollen allergens. Int Arch Allergy Immunol 2003; 130: 87-107. (Pubitemid 36351233)
31. Mohapatra SS, Lockey RF, Shirley S: Immunobiology of grass pollen allergens. Curr Allergy Asthma Rep 2005; 5: 381-387. (Pubitemid 41683981)
32. Vrtala S, Susani M, Sperr WR, Valent P, Laffer S, Dolecek C, Kraft D, Valenta R: Immunologic characterization of purified recombinant timothy grass pollen ( Phleum pratense ) allergens (Phl p 1, Phl p 2, Phl p 5). J Allergy Clin Immunol 1996; 97: 781-787. (Pubitemid 26089252)
33. Roesler E, Weiss R, Weinberger EE, Fruehwirth A, Stoecklinger A, Mostbock S, Ferreira F, Thalhamer J, Scheiblhofer S: Immunize and disappear-safety- optimized mRNA vaccination with a panel of 29 allergens. J Allergy Clin Immunol 2009; 124: 1070-1077.
34. Müller WD, Karamfilov T, Kahlert H, Stüwe HT, Fahlbusch B, Cromwell O, Fiebig H, Jäger L: Mapping of T cell epitopes of Phl p 5: evidence for crossreacting and non-crossreacting T cell epitopes within Phl p 5 isoallergens. Clin Exp Allergy 1998; 28: 1538-1548. (Pubitemid 29003330)
35. Oseroff C, Sidney J, Kotturi MF, Kolla R, Alam R, Broide DH, Wasserman SI, Weiskopf D, McKinney DM, Chung JL, Petersen A, Grey H, Peters B, Sette A: Molecular determinants of T cell epitope recognition to the common timothy grass allergen. J Immunol 2010; 185: 943-955.
36. Hartl A, Weiss R, Hochreiter R, Scheiblhofer S, Thalhamer J: DNA vaccines for allergy treatment. Methods 2004; 32: 328-339. (Pubitemid 38201287)
37. Danzer M, Polin H, Proll J, Hofer K, Fae I, Fischer GF, Gabriel C: High-throughput sequence-based typing strategy for HLA-drb1 based on real-time polymerase chain reaction. Hum Immunol 2007; 68: 915-917. (Pubitemid 350235727)
38. Liu H, Rhodes M, Wiest DL, Vignali DA: On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 2000; 13: 665-675.
39. Dimopoulos N, Jackson HM, Ebert L, Guillaume P, Luescher IF, Ritter G, Chen W: Combining MHC tetramer and intracellular cytokine staining for CD8+ T cells to reveal antigenic epitopes naturally presented on tumor cells. J Immunol Methods 2009; 340: 90-94.